综述 Review

植物多糖通过核因子κB及丝裂原活化蛋白激酶/核因子E2相关因子2信号通路发挥抗氧化作用的机制

展开
  • 山东农业大学动物科技学院, 山东省动物生物工程与疾病防治重点实验室, 泰安 271018
王丽雪(1991-),女,山东泰安人,硕士研究生,研究方向动物营养与饲料科学。E-mail:lxwang1119@163.com

收稿日期: 2018-03-29

  网络出版日期: 2018-10-20

基金资助

山东省牧草产业体系饲草营养岗(SDAIT-23-05);山东省农业重大应用技术创新项目"粮改饲高产高效生产利用模式与关键技术的集成示范";山东省"双一流"奖补资金;山东省农业科学院农业科技创新工程(CXGC2017B02)

Plant Polysaccharides: Mechanism of Anti-Oxidant Action through Nuclear Factor κB and Mitogen-Activated Protein Kinase/Nuclear Factor Erythroid 2-Related Factor 2 Signaling Pathways

Expand
  • Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China

Received date: 2018-03-29

  Online published: 2018-10-20

摘要

植物多糖是植物提取物中重要活性成分之一,具有抗氧化、免疫增强、抗肿瘤等多种生物学作用。在抗氧化作用方面,植物多糖通过核因子κB(NF-κB)信号通路减少炎症因子的分泌,缓解氧化应激损伤;通过丝裂原活化蛋白激酶/核因子E2相关因子2(MAPK/Nrf2)信号通路清除机体或细胞内自由基,提高抗氧化酶活性或含量,增强机体或细胞对氧化应激的抗性。本文主要综述了氧化应激产生的原因及其危害,并阐述NF-κB及MAPK/Nrf2信号通路在植物多糖发挥抗氧化作用中的研究现状以及存在问题,为植物多糖作为抗氧化剂的研究与应用提供理论参考。

本文引用格式

王丽雪, 解玉怀, 杨维仁, 杨在宾, 张桂国 . 植物多糖通过核因子κB及丝裂原活化蛋白激酶/核因子E2相关因子2信号通路发挥抗氧化作用的机制[J]. 动物营养学报, 2018 , 30(10) : 3857 -3863 . DOI: 10.3969/j.issn.1006-267x.2018.10.009

Abstract

Plant polysaccharides, one of the main bioactive components in plant extracts, have diverse bioactivities, such as resisting oxidative stress, boosting immunity and anti-tumor. For the antioxidative action, plant polysaccharides reduce the inflammatory factor secretion and attenuate the damage caused by oxidative stress through nuclear factor κB (NF-κB) signaling pathway; plant polysaccharides scavenge free radicals, improve activities and contents of antioxidant enzymes, and enhance cellular or body resistance to oxidative stress through mitogen-activated protein kinase (MAPK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This paper reviewed the production and the damage of oxidative stress, as well as the present situation and drawbacks of plant polysaccharides as an antioxidant regent in livestock production for the purpose of providing a theoretical foundation for the further study and application of plant polysaccharides as an antioxidant regent.

参考文献

[1] YANG B,JIANG Y M,ZHAO M M,et al.Structural characterisation of polysaccharides purified from longan (Dimocarpus longan Lour.) fruit pericarp[J].Food Chemistry,2009,115(2):609-614.  

[2] LYKKESFELDT J,SVENDSEN O.Oxidants and antioxidants in disease:oxidative stress in farm animals[J].The Veterinary Journal,2007,173(3):502-511.  

[3] CELI P,GABAI G.Oxidant/antioxidant balance in animal nutrition and health:the role of protein oxidation[J].Frontiers in Veterinary Science,2015,2:48.

[4] FINKEL T,HOLBROOK N J.Oxidants,oxidative stress and the biology of ageing[J].Nature,2000,408(6809):239-247.  

[5] VOLPI N,TARUGI P.Influence of chondroitin sulfate charge density,sulfate group position,and molecular mass on Cu2+-mediated oxidation of human low-density lipoproteins:effect of normal human plasma-derived chondroitin sulfate[J].The Journal of Biochemistry,1999,125(2):297-304.  

[6] 张丽红.紫苏叶多糖提取与抗氧化活性的研究[D].硕士学位论文.福州:福建农林大学,2013

[7] 张帆.虎皮兰多糖的提取及活性的研究[D].硕士学位论文.长春:吉林农业大学,2012.

[8] HUANG W M,LIANG Y Q,TANG L J,et al.Antioxidant and anti-inflammatory effects of Astragalus polysaccharide on EA.hy926 cells[J].Experimental and Therapeutic Medicine,2013,6(1):199-203.  

[9] SHI X J,ZHOU B S.The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos[J].Toxicological Sciences,2010,115(2):391-400.  

[10] LIU Q Y,YAO Y M,YU Y,et al.Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25high T cells[J].PLoS One,2011,6(6):e19811.

[11] CAO Y,RUAN Y,SHEN T,et al.Astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the PI3k/Akt and p38MAPK pathways[J].Oxidative Medicine and Cellular Longevity,2014,2014:674219.

[12] KAWAI T,AKIRA S.Toll-like receptor and RIG-1-like receptor signaling[J].Annals of the New York Academy of Sciences,2008,1143(1):1-20.  

[13] BARTON G M,MEDZHITOV R.Toll-like receptors and their ligands[M]//BEUTLER B,WAGNER H.Toll-like receptor family members and their ligands.Berlin:Springer,2002:81-92.

[14] MEDZHITOV R,PRESTON-HURLBURT P,JANEWAY C A Jr.A, human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J].Nature,1997,388(6640):394-397.  

[15] WANG J,LIU Y T,XIAO L,et al.Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-κB pathway[J].Inflammation,2014,37(6):2085-2090.  

[16] COUSSENS L M,WERB Z.Inflammation and cancer[J].Nature,2002,420(6917):860-867.  

[17] LIN W W,KARIN M.A cytokine-mediated link between innate immunity,inflammation,and cancer[J].Journal of Clinical Investigation,2007,117(5):1175-1183.  

[18] LIU F,WU S,REN H W,et al.Klotho suppresses RIG-Ⅰ-mediated senescence-associated inflammation[J].Nature Cell Biology,2011,13(3):254-262.  

[19] 巩文艺,韩冬.黄芪多糖对严重烧伤大鼠心肌组织氧化应激和炎症反应的影响[J].中国中医急症,2016,25(6):1005-1007,1022.

[20] 李胜陶,王洪新,杨娟,等.黄芪多糖对异丙肾上腺素诱导大鼠心肌肥厚中TLR4/NF-κB信号通路的影响[J].中成药,2014,36(4):674-679.

[21] XIE G,SCHEPETKIN I A,QUINN M T.Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.[J].International Immunopharmacology,2007,7(13):1639-1650.  

[22] PARK C M,CHO C W,SONG Y S.TOP 1 and 2,polysaccharides from Taraxacum officinale,inhibit NFκB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells[J].Food and Chemical Toxicology,2014,66:56-64.

[23] KYRIAKIS J M,AVRUCH J.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation[J].Physiological Reviews,2001,81(2):807-869.  

[24] MCCUBREY J A,LAHAIR M M,FRANKLIN R A.Reactive oxygen species-induced activation of the MAP kinase signaling pathways[J].Antioxidants & Redox Signaling,2006,8(9/10):1775-1789.

[25] GAO Q H,FU X Y,ZHANG R,et al.Neuroprotective effects of plant polysaccharides:A review of the mechanisms[J].International Journal of Biological Macromolecules,2017,106:749-754.

[26] ANDO I,TSUKUMO Y,WAKABAYASHI T,et al.Safflower polysaccharides activate the transcription factor NF-κB via Toll-like receptor 4 and induce cytokine production by macrophages[J].International Immunopharmacology,2002,2(8):1155-1162.  

[27] ZHANG D,SUN Y,YUE Z G,et al.Apple polysaccharides induce apoptosis in colorectal cancer cells[J].International Journal of Molecular Medicine,2012,30(1):100-106.

[28] YING C,DUAN J A,QIAN D W,et al.Assessment and comparison of immunoregulatory activity of four hydrosoluble fractions of Angelica sinensis in vitro on the peritoneal macrophages in ICR mice[J].International Immunopharmacology,2010,10(4):422-430.  

[29] ZHANG X R,LI Y J,CHENG J P,et al.Immune activities comparison of polysaccharide and polysaccharide-protein complex from Lycium barbarum L.[J].International Journal of Biological Macromolecules,2014,65:441-445.

[30] ZHANG X R,QI C H,YAN G,et al.Toll-like receptor 4-related immunostimulatory polysaccharides:primary structure,activity relationships,and possible interaction models[J].Carbohydrate Polymers,2016,149:186-206.

[31] HUANG Y F,LU L,ZHU D J,et al.Effects of Astragalus polysaccharides on dysfunction of mitochondrial dynamics induced by oxidative stress[J].Oxidative Medicine and Cellular Longevity,2016,2016:9573291.

[32] LIU H W,DONG X F,TONG J M,et al.Alfalfa polysaccharides improve the growth performance and antioxidant status of heat-stressed rabbits[J].Livestock Science,2010,131(1):88-93.  

[33] WANG S P,DONG X F,MA H,et al.Purification,characterisation and protective effects of polysaccharides from alfalfa on hepatocytes[J].Carbohydrate Polymers,2014,112(2):608-614.

[34] ZHAO Z Y,XU X J,YE Q W,et al.Ultrasound extraction optimization of Acanthopanax senticosus polysaccharides and its antioxidant activity[J].International Journal of Biological Macromolecules,2013,59:290-294.

[35] HE M,PAN H,CHANG R C,et al.Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage[J].PLoS One,2014,9(1):e84800.
文章导航

/