综述 Review

植物多酚对氧化应激与炎症信号通路的调控机制

展开
  • 1. 湖南农业大学动物医学院, 长沙 410128;
    2. 湖南农业大学动物科学技术学院, 长沙 410128
贺宇佳(1998-),女,湖南长沙人,本科生,从事分子营养与抗病机制研究。E-mail:hyj39306@163.com

收稿日期: 2018-12-17

  网络出版日期: 2019-04-16

基金资助

国家自然科学基金应急管理项目(31741115);动物营养学国家重点实验室开放课题(2004DA125184F1724);湖南省百人计划(2017)

Regulation Mechanism of Plant Polyphenols in Oxidative Stress and Inflammatory Signaling Pathways

Expand
  • 1. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China;
    2. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2018-12-17

  Online published: 2019-04-16

摘要

炎症及氧化应激是造成动物机体组织和器官损伤的主要原因之一,肠道炎症可造成肠黏膜损伤,进而影响其屏障功能,减弱动物对外界刺激的防御能力。植物多酚具有抗氧化、抗炎、调节肠道菌群等多种潜在功效,且具有低毒、无耐药性等特点,因此,在新型饲料添加剂的开发中具有广阔的应用前景。但目前大部分植物多酚在动物体内的代谢及调控机制尚不明确,这极大阻碍了其合理有效利用。本文基于近期研究就植物多酚对氧化应激与炎症信号通路的调控机制进行综述,为其在新型饲料添加剂中的应用提供理论依据。

本文引用格式

贺宇佳, 刘明, 伍树松 . 植物多酚对氧化应激与炎症信号通路的调控机制[J]. 动物营养学报, 2019 , 31(4) : 1554 -1563 . DOI: 10.3969/j.issn.1006-267x.2019.04.012

Abstract

Inflammation and oxidative stress are main causes of tissue and organ damage in animals. The intestinal inflammation may cause damage to intestinal mucosa, and thereby affecting its barrier function and weakening the animal's ability to defend against external stimuli. Plant polyphenols are characterized by low toxicity and no drug resistance, and possess multiple potential biological effects such as antioxidant, anti-inflammation and intestinal flora regulation. Therefore, polyphenols have a wide application prospect in the development of novel feed additives. However, polyphenols have not been used rationally since the metabolic and regulatory mechanisms of most plant polyphenols are still not clear. Based on recent studies, this paper has summarized the regulation of oxidative stress and inflammatory signaling pathways by plant polyphenols to provide a theoretical basis for their application in novel feed additives.

参考文献

[1] MEDZHITOV R.Origin and physiological roles of inflammation[J].Nature,2008,454(7203):428-435.  

[2] ASAGIRI M,HIRAI T,KUNIGAMI T,et al.Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis[J].Science,2008,319(5863):624-627.  

[3] NEURATH M F.Cytokines in inflammatory bowel disease[J].Nature Reviews Immunology,2014,14(5):329-342.  

[4] HOTAMISLIGIL G S.Inflammation and metabolic disorders[J].Nature,2006,444(7121):860-867.  

[5] DEL RIO D,RODRIGUEZ-MATEOS A,SPENCER J P E,et al.Dietary (poly)phenolics in human health:structures,bioavailability,and evidence of protective effects against chronic diseases[J].Antioxidants & Redox Signalling,2013,18(14):1818-1892.  

[6] TSAO R.Chemistry and biochemistry of dietary polyphenols[J].Nutrients,2010,2(12):1231-1246.  

[7] IQBAL Z,KAMRAN Z,SULTAN J I,et al.Replacement effect of vitamin E with grape polyphenols on antioxidant status,immune,and organs histopathological responses in broilers from 1-to 35-d age[J].The Journal of Applied Poultry Research,2015,24(2):127-134.  

[8] ARTS I C,HOLLMAN P C.Polyphenols and disease risk in epidemiologic studies[J].The American Journal of Clinical Nutrition,2005,81(1):317S-325S.

[9] GRAF B A,MILBURY P E,BLUMBERG J B.Flavonols,flavones,flavanones,and human health:epidemiological evidence[J].Journal of Medicinal Food,2005,8(3):281-90.  

[10] ZHAO J X,LI Q,ZHANG R X,et al.Effect of dietary grape pomace on growth performance,meat quality and antioxidant activity in ram lambs[J].Animal Feed Science and Technology,2018,236:76-85.

[11] WU S,YANO S,HISANAGA A,et al.Polyphenols from Lonicera caerulea L. berry attenuate experimental nonalcoholic steatohepatitis by inhibiting proinflammatory cytokines productions and lipid peroxidation[J].Molecular Nutrition and Food Research,2017,61(4),doi:10.1002/mnfr.201600858.

[12] WU S S,YANO S,CHEN J H,et al.Polyphenols from Lonicera caerulea L.Berry inhibit LPS-induced inflammation through dual modulation of inflammatory and antioxidant mediators[J].Journal of Agricultural and Food Chemistry,2017,65(25):5133-5141.  

[13] WU S S,HU R Z,NAKANO H,et al.Modulation of gut microbiota by Lonicera caerulea L.Berry polyphenols in a mouse model of fatty liver induced by high fat diet[J].Molecules,2018,23(12):3213.

[14] KORHONEN R,LAHTI A,KANKAANRANTA H,et al.Nitric oxide production and signaling in inflammation[J].Current Drug Targets:Inflammation and Allergy,2005,4(4):471-479.  

[15] ZHOU L,ZHU D Y.Neuronal nitric oxide synthase:structure,subcellular localization,regulation,and clinical implications[J].Nitric Oxide,2009,20(4):223-230.  

[16] SHAUL P W.Regulation of endothelial nitric oxide synthase:location,location,location[J].Annual Review of Physiology,2002,64:749-774.

[17] FÖRSTERMANN U,MVNZEL T.Endothelial nitric oxide synthase in vascular disease:from marvel to menace[J].Circulation,2006,113(3):1708-1714.

[18] ALDERTON W K,COOPER C E,KNOWLES R G.Nitric oxide synthases:structure,function and inhibition[J].Biochemical Journal,2001,357(3):593-615.  

[19] AKTAN F.iNOS-mediated nitric oxide production and its regulation[J].Life Sciences,2004,75(6):639-653.  

[20] MORITA I.Distinct functions of COX-1 and COX-2[J].Prostaglandins & Other Lipid Mediators,2002,68/69:165-175.

[21] RICCIOTTI E,FITZGERALD G A.Prostaglandins and inflammation[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2011,31(5):986-1000.  

[22] KALINSKI P.Regulation of immune responses by prostaglandin E2[J].Journal of Immunology,2012,188(1):21-28.  

[23] ZHANG J M,AN J X.Cytokines,inflammation,and pain[J].International Anesthesiology Clinics,2007,45(2):27-37.  

[24] MOSER B,WILLIMANN K.Chemokines:role in inflammation and immune surveillance[J].Annals of the Rheumatic Diseases,2004,63(Suppl 2):ii84-ii89.

[25] WOODWARD E A,KOLESNIK T B,NICHOLSON S E,et al.The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10,RP105 or the kinase activity of RIPK2[J].Cytokine,2012,58(3):415-423.  

[26] YASUKAWA H,OHISHI M,MORI H,et al.IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages[J].Nature Immunology,2003,4(6):551-556.  

[27] VAN KAMPEN C,GAULDIE J,COLLINS S M.Proinflammatory properties of IL-4 in the intestinal microenvironment[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2004,288(1):G111-G117.

[28] BRENNAN F M,MCINNES I B.Evidence that cytokines play a role in rheumatoid arthritis[J].Journal of Clinical Investigation,2008,118(11):3537-3545.  

[29] SUTTON C,BRERETON C,KEOGH B,et al.A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis[J].Journal of Experimental Medicine,2006,203(7):1685-1691.  

[30] COGGINS M,ROSENZWEIG A.The fire within:cardiac inflammatory signaling in health and disease[J].Circulation Research,2012,110(1):116-125.  

[31] NEWTON K,DIXIT V M.Signaling in innate immunity and inflammation[J].Cold Spring Harbor Perspectives in Biology,2012,4(3):a006049.

[32] KAMINSKA B.MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits[J].Biochimica et Biophysica Acta:Proteins and Proteomics,2005,1754(1/2):253-262.

[33] LAWRENCE T.The nuclear factor NF-κB pathway in inflammation[J].Cold Spring Harbor Perspectives in Biology,2009,1(6):a001651.

[34] KIM E K,CHOI E J.Pathological roles of MAPK signaling pathways in human diseases[J].Biochimica et Biophysica Acta:Molecular Basis of Disease,2010,1802(4):396-405.  

[35] WESTON C R,DAVIS R J.The JNK signal transduction pathway[J].Current Opinion in Genetics & Development,2002,12(1):14-21.  

[36] SHAUL Y D,SEGER R.The MEK/ERK cascade:from signaling specificity to diverse functions[J].Biochimica et Biophysica Acta:Molecular Cell Research,2007,1773(8):1213-1226.  

[37] WATANABE Y,NAGAI Y,TAKATSU K.Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance[J].Nutrients,2013,5(9):3757-3778.  

[38] AGGARWAL B B,VIJAYALEKSHMI R V,SUNG B.Targeting inflammatory pathways for prevention and therapy of cancer:short-term friend,long-term foe[J].Clinical Cancer Research,2009,15(2):425-430.  

[39] ADHIKARI A,XU M,CHEN Z J.Ubiquitin-mediated activation of TAK1 and IKK[J].Oncogene,2007,26(22):3214-3226.  

[40] KYRIAKIS J M,AVRUCH J.Mammalian MAPK signal transduction pathways activated by stress and inflammation:a 10-year update[J].Physiological Reviews,2012,92(2):689-737.  

[41] SHIH R H,WANG C Y,YANG C M.NF-kappaB signaling pathways in neurological inflammation:a mini review[J].Frontiers in Molecular Neuroscience,2015,8:77.

[42] REUTER S,GUPTA S C,CHATURVEDI M M,et al.Oxidative stress,inflammation,and cancer:how are they linked?[J].Free Radical Biology and Medicine,2010,49(11):1603-1616.  

[43] PARAVICINI T M,TOUYZ R M.NADPH oxidases,reactive oxygen species,and hypertension:clinical implications and therapeutic possibilities[J].Diabetes Care,2008,31 Suppl 2:S170-S180.

[44] BEDARD K,KRAUSE K H.The NOX family of ROS-generating NADPH oxidases:physiology and pathophysiology[J].Physiological Reviews,2007,87(1):245-313.  

[45] PANDAY A,SAHOO M K,OSORIO D,et al.NADPH oxidases:an overview from structure to innate immunity-associated pathologies[J].Cellular and Molecular Immunology,2014,12(1):5-23.

[46] CHO R L,YANG C C,LEE I T,et al.Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cells[J].American Journal of Physiology,2016,310(7):L639-L657.

[47] FOURQUET S,GUEROIS R,BIARD D,et al.Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation[J].Journal of Biological Chemistry,2010,285(11):8463-8471.  

[48] RUSHWORTH S A,CHEN X L,MACKMAN N,et al.Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C[J].Journal of Immunology,2005,175(7):4408-4415.  

[49] TANIGAWA S,FUJⅡ M,HOU D X.Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin[J].Free Radical Biology and Medicine,2007,42(11):1690-1703.  

[50] SINGH A,RANGASAMY T,THIMMULAPPA R K,et al.Glutathione peroxidase 2,the major cigarette smoke-inducible isoform of GPX in lungs,is regulated by Nrf2[J].American Journal of Respiratory Cell and Molecular Biology,2006,35(6):639-650.  

[51] HUANG X S,CHEN H P,YU H H,et al.Nrf2-dependent upregulation of antioxidative enzymes:a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection[J].Molecular and Cellular Biochemistry,2014,385(1/2):33-41.

[52] TAKADA Y,MUKHOPADHYAY A,KUNDU G C,et al.Hydrogen peroxide activates NF-κB through tyrosine phosphorylation of I κBα and serine phosphorylation of p65:evidence for the involvement of I κBα kinase and Syk protein-tyrosine kinase[J].Journal of Biological Chemistry,2003,278(26):24233-24241.  

[53] CHEN K,KIRBER M T,XIAO H,et al.Regulation of ROS signal transduction by NADPH oxidase 4 localization[J].Journal of Cell Biology,2008,181(7):1129-1139.  

[54] SALZANO S,CHECCONI P,HANSCHMANN E M,et al.Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2,which acts as a danger signal[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(33):12157-12162.  

[55] BHATTACHARYYA A,CHATTOPADHYAY R,MITRA S,et al.Oxidative stress:an essential factor in the pathogenesis of gastrointestinal mucosal diseases[J].Physiological Reviews,2014,94(2):329-354.  

[56] HEIM K E,TAGLIAFERRO A R,BOBILYA D J.Flavonoid antioxidants:chemistry,metabolism and structure-activity relationships[J].Journal of Nutritional Biochemistry,2002,13(10):572-584.  

[57] NEUDÖRFFER A,DESVERGNE J P,BONNEFONT-ROUSSELOT D,et al.Protective effects of 4-hydroxycinnamic ethyl ester derivatives and related dehydrodimers against oxidation of LDL:radical scavengers or metal chelators?[J].Journal of Agricultural and Food Chemistry,2006,54(5):1898-1905.  

[58] KUREK-GÍRECKA A,RZEPECKA-STOJKO A,GÍRECKI M,et al.Structure and antioxidant activity of polyphenols derived from propolis[J].Molecules,2013,19(1):78-101.  

[59] WU N,ZU Y G,FU Y J,et al.Antioxidant activities and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds obtained from Geranium sibiricum L.[J].Journal of Agricultural and Food Chemistry,2010,58(8):4737-4743.  

[60] PIGNATELLI P,DI SANTO S,BUCHETTI B,et al.Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation:effect on platelet recruitment[J].The FASEB Journal,2006,20(8):1082-1089.  

[61] ANDJELKOVIC M,VANCAMP J,DEMEULENAER B,et al.Iron-chelation properties of phenolic acids bearing catechol and galloyl groups[J].Food Chemistry,2006,98(1):23-31.  

[62] GAN W T,DANG Y Q,HAN X,et al.ERK5/HDAC5-mediated,resveratrol-,and pterostilbene-induced expression of MnSOD in human endothelial cells[J].Molecular Nutrition and Food Research,2016,60(2):266-277.  

[63] LEON-GONZÁLEZ A J,AUGER C,SCHINI-KERTH V B.Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy[J].Biochemical Pharmacology,2015,98(3):371-80.  

[64] ERLANK H,ELMANN A,KOHEN R,et al.Polyphenols activate Nrf2 in astrocytes via H2O2,semiquinones,and quinones[J].Free Radical Biology and Medicine,2011,51(12):2319-2327.  

[65] LIU M,TAN J J,HE Z Y,et al.Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice[J].Animal Nutrition,2018,4(3):288-293.  

[66] QUIDEAU S,DEFFIEUX D,DOUAT-CASASSUS C,et al.Plant polyphenols:chemical properties,biological activities,and synthesis[J].Angewandte Chemie International Edition,2011,50(3):586-621.  

[67] JEAN-GILLES D,LI L Y,MA H,et al.Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model[J].Journal of Agricultural and Food Chemistry,2012,60(23):5755-5762.  

[68] GIACOPPO S,GALUPPO M,LOMBARDO G E,et al.Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis[J].Fitoterapia,2015,103:171-186.

[69] MARTIN D A,BOLLING B W.A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases[J].Food & Function,2015,6(6):1773-1786.  

[70] LOKE W M,PROUDFOOT J M,HODGSON J M,et al.Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2010,30(4):749-757.  

[71] NAKAMURA Y,ISHⅡ T,ABE N,et al.Thiol modification by bioactivated polyphenols and its potential role in skin inflammation[J].Bioscience,Biotechnology,and Biochemistry,2014,78(6):1067-1070.  

[72] AMIOT M J,RIVA C,VINET A.Effects of dietary polyphenols on metabolic syndrome features in humans:a systematic review[J].Obesity Reviews,2016,17(7):573-586.  

[73] CRASCÌ L,LAURO M R,PUGLISI G,et al.Natural antioxidant polyphenols on inflammation management:anti-glycation activity vs metalloproteinases inhibition[J].Critical Reviews in Food Science and Nutrition,2016,58(6):893-904.

[74] BYUN E H,FUJIMURA Y,YAMADA K,et al.TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor[J].The Journal of Immunology,2010,185(1):33-45.  

[75] QIAN Z J,WU Z Q,HUANG L,et al.Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice[J].Scientific Reports,2015,5:17348.

[76] ROMIER B,VAN DE WALLE J,DURING A,et al.Modulation of signalling nuclear factor-κB activation pathway by polyphenols in human intestinal Caco-2 cells[J].British Journal of Nutrition,2008,100(3):542-551.  

[77] KIM M H,YOO D S,LEE S Y,et al.The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol,contributing to its broad-spectrum anti-inflammatory effects[J].Pharmazie,2011,66(4):293-300.

[78] HISANAGA A,MUKAI R,SAKAO K,et al.Anti-inflammatory effects and molecular mechanisms of 8-prenyl quercetin[J].Molecular Nutrition and Food Research,2016,60(5):1020-1032.  

[79] BASELGA-ESCUDERO L,BLADE C,RIBAS-LATRE A,et al.Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells[J].Nucleic Acids Research,2014,42(2):882-892.  

[80] VAN BUITEN C B,LAMBERT J D,ELIAS R J.Green tea polyphenols mitigate gliadin-mediated inflammation and permeability in vitro[J].Molecular Nutrition & Food Research,2018,62(12):1700879.

[81] JOSEPH S V,EDIRISINGHE I,BURTON-FREEMAN B M.Fruit polyphenols:a review of anti-inflammatory effects in humans[J].Critical Reviews in Food Science and Nutrition,2016,56(3):419-444.  

[82] DE LA LUZ CÁDIZ-GURREA M,MICOL V,JOVEN J,et al.Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells[J].Food Research International,2018,doi:10.1016/j.foodres.2018.02.027.

[83] JOSKOVA M,SADLONOVA V,NOSALOVA G,et al.Polyphenols and their components in experimental allergic asthma[M]//POKORSKI M.Respiratory regulation-the molecular approach.Dordrecht:Springer,2013,756:91-98.
文章导航

/