秦春力, 吕景智, 贺稚非, 李洪军 . 褪黑素对核苷酸结合寡聚域样受体蛋白3炎性小体的影响及其机制[J]. 动物营养学报, 2019 , 31(5) : 2069 -2075 . DOI: 10.3969/j.issn.1006-267x.2019.05.013

[1] LEVY M,THAISS C A,ELINAV E.Taming the inflammasome[J].Nature Medicine,2015,21(3):213-215.  

[2] ZHOU R B,YAZDI A S,MENU P,et al.A role for mitochondria in NLRP3 inflammasome activation[J].Nature,2011,469(7329):221-225.  

[3] SABROE I,PARKER L C,DOWER S K,et al.The role of TLR activation in inflammation[J].Journal of Pathology,2010,214(2):126-135.

[4] LATZ E,XIAO T S,STUTZ A.Activation and regulation of the inflammasomes[J].Nature Reviews Immunology,2013,13(6):397-411.  

[5] HERNANDEZ-CUELLAR E,TSUCHIYA K,HARA H,et al.Cutting edge:nitric oxide inhibits the NLRP3 inflammasome[J].Journal of Immunology,2012,189(11):5113-5117.  

[6] RATHINAM V A K,VANAJA S K,FITZGERALD K A.Regulation of inflammasome signaling[J].Nature Immunology,2012,13(4):333-342.  

[7] LEE S,SUH G Y,RYTER S W,et al.Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor,pyrin domain-containing-3 inflammasome in lung disease[J].American Journal of Respiratory Cell and Molecular Biology,2016,54(2):151-60.  

[8] MARTÍNEZ G J,ROBERTSON S,BARRACLOUGH J,et al.Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome[J].Journal of the American Heart Association,2015,4(8):e002128.

[9] KIM S,JOE Y,JEONG S O,et al.Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways[J].Innate Immunity,2014,20(8):799-815.  

[10] OVERLEY-ADAMSON B,ARTLETT C M,STEPHENS C,et al.Targeting the unfolded protein response,XBP1,and the NLRP3 inflammasome in fibrosis and cancer[J].Cancer Biology & Therapy,2014,15(4):452-462.  

[11] FANN D Y W,SANTRO T,MANZANERO S,et al.Intermittent fasting attenuates inflammasome activity in ischemic stroke[J].Experimental Neurology,2014,257:114-119.

[12] HOEGEN T,TREMEL N,KLEIN M,et al.The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release[J].The Journal of Immunology,2011,187(10):5440-5451.  

[13] LI J,WANG Y L,WANG Y P,et al.Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction[J].Journal of Molecular and Cellular Cardiology,2015,86:62-74.

[14] BECKER C E,O'NEILL L A J.Inflammasomes in inflammatory disorders:the role of TLRs and their interactions with NLRs[J].Seminars in Immunopathology,2007,29(3):239-248.  

[15] TAKEDA K,KAISHO T,AKIRA S.Toll-like receptors[J].Annual Review of Immunology,2003,21(1):335-376.  

[16] AKIRA S,TAKEDA K.Toll-like receptor signalling[J].Nature Reviews Immunology,2004,4(7):499-511.  

[17] 陈洁,姜虹.TLR4信号通路与炎性反应[J].医学综述,2009,15(19):2902-2904.

[18] FITZGERALD K A,MCWHIRTER S M,FAIA K L,et al.IKKε epsilon and TBK1 are essential components of the IRF3 signaling pathway[J].Nature Immunology,2003,4(5):491-496.  

[19] SHIBOLET O,PODOLSKY D K.TLRs in the Gut.Ⅳ.negative regulation of Toll-like receptors and intestinal homeostasis:addition by subtraction[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2007,292(6):1469-1473.  

[20] QIAO Y,WANG P,QI J N,et al.TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages[J].FEBS Letters,2012,586(7):1022-1026.  

[21] BOARU S G,BORKHAM-KAMPHORST E,VAN DE LEUR E,et al.NLRP3 inflammasome expression is driven by NF-κB in cultured hepatocytes[J].Biochemical and Biophysical Research Communications,2015,458(3):700-706.  

[22] ORTIZ F,ACUÑA-CASTROVIEJO D,DOERRIER C,et al.Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis[J].Journal of Pineal Research,2015,58(1):34-49.  

[23] GARCÍA J A,VOLT H,VENEGAS C,et al.Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice[J].FASEB Journal,2015,29(9):3863-3875.  

[24] ZHANG Y,LI X R,GRAILER J J,et al.Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome[J].Journal of Pineal Research,2016,60(4):405-414.  

[25] DONG Y S,FAN C X,HU W,et al.Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling[J].Journal of Pineal Research,2016,60(3):253-262.  

[26] KANG J W,KOH E J,LEE S M.Melatonin protects liver against ischemia and reperfusion injury through inhibition of Toll-like receptor signaling pathway[J].Journal of Pineal Research,2011,50(4):403-411.  

[27] CHUFFA L G A,FIORUCI-FONTANELLI B A,MENDES L O,et al.Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer[J].BMC Cancer,2015,15:34.

[28] BEKYAROVA G,BRATCHKOVA Y,TANCHEVA S,et al.Effective melatonin protection of burn-induced hepatic disorders in rats[J].Central European Journal of Medicine,2012,7(4):533-538.

[29] MUXEL S M,PIRES-LAPA M A,MONTEIRO A W A,et al.NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene[J].PLoS One,2012,7(12):e52010.

[30] CARRILLO-VICO A,LARDONE P J,ÁLVAREZ-SÁNCHEZ N,et al.Melatonin:buffering the immune system[J].International Journal of Molecular Sciences,2013,14(4):8638-8683.  

[31] MANCHESTER L C,COTO-MONTES A,BOGA J A,et al.Melatonin:an ancient molecule that makes oxygen metabolically tolerable[J].Journal of Pineal Research,2015,59(4):403-419.  

[32] MALDONADO M D,GARCÍA-MORENO H,GONZÁLEZ-YANES C,et al.Possible involvement of the inhibition of NF-κB factor in anti-inflammatory actions that melatonin exerts on mast cells[J].Journal of Cellular Biochemistry,2016,117(8):1926-1933.  

[33] AKASHI M,TAKUMI T.The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1[J].Nature Structural & Molecular Biology,2005,12(5):441-448.  

[34] CRUMBLEY C,WANG Y J,KOJETIN D J,et al.Characterization of the core mammalian clock component,NPAS2,as a REV-ERBα/RORα target gene[J].Journal of Biological Chemistry,2010,285(46):35386-35392.  

[35] SPENGLER M L,KUROPATWINSKI K K,COMAS M,et al.Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(37):E2457-E2465.

[36] RAHIM I,DJERDJOURI B,SAYED R K,et al.Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis[J].Journal of Pineal Research,2017,63(1):e12410.

[37] ACUÑACA-STROVIEJO D,REITER R J,MENÉNDEZ-PELÁEZ A,et al.Characterization of high-affinity melatonin binding sites in purified cell nuclei of rat liver[J].Journal of Pineal Research,1994,16(2):100-112.  

[38] WIESENBERG I,MISSBACH M,CARLBERG C.The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signaling[J].Restorative Neurology & Neuroscience,1998,12(2/3):143-150.

[39] BROOM L J,KOGUT M H.Inflammation:friend or foe for animal production?[J].Poultry Science,2017,97(2):510-514.

[40] JIANG Z,SCHATZMAYR G,MOHNL M,et al.Net effect of an acute phase response-partial alleviation with probiotic supplementation[J].Poultry Science,2010,89(1):28-33.  

[41] CHANDRA R K.Nutrition and the immune system[J].Proceedings of the Nutrition Society,1993,52(1):77-84.  

[42] LABUSSIōRE E,DUBOIS S,GILBERT H,et al.Effect of inflammation stimulation on energy and nutrient utilization in piglets selected for low and high residual feed intake[J].Animal,2015,9(10):1653-1661.  

[43] BALLINGER B A,AZOOZ O,EL-HAJ T,et al.Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis[J].Gut,2000,46(5):695-700.  

[44] SAWCZENKO A,AZOOZ O,PARASZCZUK J,et al.Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the-174 IL-6 G/C polymorphism in children[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(37):13260-13265.  

[45] CONNOR E E,BALDWIN R L,BLANTON J R,Jr,et al.Growth and development symposium:understanding and mitigating the impacts of inflammation on animal growth and development[J].Journal of Animal Science,2012,90(5):1436-1437.  

[46] SANDBERG F B,EMMANS G C,KYRIAZAKIS I.The effects of pathogen challenges on the performance of naïe and immune animals:the problem of prediction[J].Animal,2007,1(1):67-86.  

[47] WEBEL D M,JOHNSON R W,BAKER D H.Lipopolysaccharide-induced reductions in food intake do not decrease the efficiency of lysine and threonine utilization for protein accretion in chickens[J].The Journal of Nutrition,1998,128(10):1760-1766.