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维生素A对动物氧化应激的减缓作用机制

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  • 1. 内蒙古农业大学动物科学学院, 呼和浩特 010018;
    2. 海南大学动物科技学院, 海口 570228
石惠宇(1988-),女,蒙古族,内蒙古清水河人,讲师,博士,从事动物矿物质与维生素营养研究。E-mail:shihuiyu2017@163.com

收稿日期: 2018-12-10

  网络出版日期: 2019-06-17

基金资助

国家自然科学基金项目(31160466)

Mitigation Mechanism of Vitamin A on Oxidative Stress in Animals

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  • 1. College of Animal Science, Inner Mongolia Agricultural University, Huhhot 010018, China;
    2. College of Animal Science and Technology, Hainan University, Haikou 570228, China

Received date: 2018-12-10

  Online published: 2019-06-17

摘要

花生四烯酸(ARA)、活性氧和一氧化氮(NO)过量产生可以引起细胞氧化损伤。维生素A可以有效地调控ARA和NO的生成,在减缓氧化应激方面发挥着重要作用。本文主要从提高硒蛋白谷胱甘肽过氧化物酶(GPx)和硫氧还蛋白还原酶(TrxR)的表达和活性、通过TrxR/丝裂原活化蛋白激酶(MAPK)途径和核因子E2相关因子2(Nrf2)/GPx1/核转录因子-κB(NF-κB)途径对ARA及NO进行调节2个方面综述了维生素A对动物氧化应激的减缓作用机制,为深入研究维生素A对氧化应激的调节机制提供理论依据。

本文引用格式

石惠宇, 闫素梅 . 维生素A对动物氧化应激的减缓作用机制[J]. 动物营养学报, 2019 , 31(6) : 2458 -2464 . DOI: 10.3969/j.issn.1006-267x.2019.06.002

Abstract

Excessive production of arachidonic acid (ARA), reactive oxygen species and nitric oxide (NO) can cause oxidative damage in cells. Vitamin A can effectively regulate ARA and NO production and play an important role in alleviating oxidative stress. In this paper, the mitigation mechanism of vitamin A on oxidative stress of animals was reviewed from the point of views of increasing the expression and activities of selenoprotein glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), and regulating the excessive production of ARA and NO via TrxR/mitogen activated protein kinase (MAPK) pathway and nuclear factor E2 related factor 2 (Nrf2)/GPx1/nuclear transcription factor-κB (NF-κB) pathway. It would provide a theoretical basis for the study of the regulation mechanism of vitamin A on oxidative stress.

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