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脂肪酸移位酶CD36/SR-B2及其介导的长链脂肪酸跨膜转运

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  • 1. 西南大学动物科学学院, 重庆 402460;
    2. 中国科学院亚热带农业生态研究所, 亚热带农业生态过程重点实验室, 畜禽养殖污染控制与资源化技术国家工程实验室, 湖南省畜禽健康养殖工程技术研究中心, 农业部中南动物营养与饲料科学观测实验站, 长沙 410125;
    3. 习水富兴牧业有限公司, 习水 556400;
    4. 白玉县牧旺农业科技有限公司, 白玉 627150;
    5. 白玉玉牧丰源畜牧科技有限公司, 白玉 627150
骆东梅(1994-),女,重庆云阳人,硕士研究生,研究方向为动物生态营养与环境。E-mail:1570135773@qq.com

收稿日期: 2018-12-04

  网络出版日期: 2019-06-17

基金资助

国家自然科学基金项目(31872386);四川省科技计划项目(2019YFN0080);四川省政府采购项目(5133312018000053)

Fatty Acid Translocase CD36/SR-B2 and Its Mediation in Transmembrane Transportation of Long-Chain Fatty Acids

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  • 1. College of Animal Science, Southwest University, Chongqing 402460, China;
    2. Key Laboratory for Agri-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Research Center of Livestock and Poultry Sciences, South Central Experimental Station of Animal Nutrition and Feed Science in Ministry of Agriculture, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China;
    3. Xishui Fuxing Husbandry Co., Ltd., Xishui 556400, China;
    4. Baiyu Muwang Agricultural Science and Technology Co., Ltd., Baiyu 627150, China;
    5. Baiyu Yumu Fengyuan Animal Husbandry Science and Technology Co., Ltd., Baiyu 627150, China

Received date: 2018-12-04

  Online published: 2019-06-17

摘要

长链脂肪酸是维持机体正常代谢的重要营养素,其吸收、转运和代谢对动物的健康、生长和生产具有重要意义。近年来,研究发现一些脂肪酸转运蛋白介导长链脂肪酸的跨膜转运。脂肪酸移位酶CD36/SR-B2是一种整合膜蛋白,能特异性介导脂肪酸在多种细胞中的跨膜转运。本文对CD36/SR-B2的由来、亚细胞定位、功能调控及其介导的长链脂肪酸跨膜转运进行概述,探讨其对脂质代谢的调控机制。

本文引用格式

骆东梅, 汪水平, 赵雪莉, 韩雪峰 . 脂肪酸移位酶CD36/SR-B2及其介导的长链脂肪酸跨膜转运[J]. 动物营养学报, 2019 , 31(6) : 2552 -2559 . DOI: 10.3969/j.issn.1006-267x.2019.06.014

Abstract

Long-chain fatty acids are important nutrients to maintain normal metabolism of the body, its absorption, transportation and metabolism have important influences on the health, growth and production of animals. In recent years, researchers have found that some fatty acid transporter proteins mediated the transportation of long-chain fatty acids across the membrane. The fatty acid translocase CD36/SR-B2 is an integrated membrane protein, which could specifically regulate the transmembrane transportation of fatty acids in many different types of cells. This paper reviewed the current understanding, subcellular localization, functional regulation of CD36/SR-B2 and the transmembrane transportation of long-chain fatty acids mediated by CD36/SR-B2, and also discussed the regulation mechanism of lipid metabolism by CD36/SR-B2.

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