本试验旨在研究5-羟色胺（5-HT）对围产期母羊生产性能及血浆和乳中钙转运相关生化指标的影响。试验选用30只巴美肉羊母羊，按体重随机分为3组，分别为对照组、5-羟基色胺酸（5-HTP）组（灌注5-HTP）和色氨酸（Trp）组（灌注Trp），每组10只。在母羊围产期产前第7天至产后第0天，进行颈静脉灌注，5-HTP和Trp的灌注剂量均为0.178 mg/kg BW，浓度为0.1 mg/mL；对照组灌注同等剂量的生理盐水。试验期为产前第7天至产后第30天。结果表明：1）各组间母羊体重无显著差异（P>0.05）。产后第5、9和15天，Trp组母羊泌乳量均低于对照组（P>0.05）；产后第9和15天，5-HTP组母羊泌乳量均高于对照组（P>0.05）。产后第16~30天，5-HTP组羔羊平均日增重显著高于对照组（P<0.05）。2）产后第15天，Trp组血浆和乳中钙浓度显著高于对照组（P<0.05）；产后第3、6和15天，5-HTP组血浆和乳中钙浓度显著高于对照组（P<0.05）。产后第6天，Trp组血浆5-HT浓度显著高于对照组（P<0.05）；产后第30天，Trp组乳中5-HT浓度显著高于对照组（P<0.05）；产后第6、9和30天，5-HTP组血浆和乳中5-HT浓度显著高于对照组（P<0.05）。产后第3、6和15天，Trp组和5-HTP组血浆甲状旁腺素相关蛋白（PTHrP）浓度均显著高于对照组（P<0.05）。由此可见，灌注5-HTP可以促进母羊泌乳，提高羊羔平均日增重；灌注5-HTP和Trp可以增加血浆和乳中钙、5-HT浓度及血浆PTHrP浓度。

This experiment was conducted to investigate effects of serotonin (5-HT) on performance and plasma and milk calcium transport related biochemical index of perinatal ewes. Thirty Bamei ewes with similar body weight were randomly allotted 3 groups, which were control group, 5-hydroxy-tryptophan (5-HTP) group (perfused 5-HTP) and tryptophan (Trp) group (perfused Trp), respectively, each group contained 10 ewes. Ewes jugular vein perfusion was conducted from prenatal day 7 to postpartum day 0, the perfusion dose of 5-HTP and Trp was 0.178 mg/kg BW, and the concentration was 0.1 mg/mL; the control group was perfused with the same dose of saline. The experiment lasted form prenatal day 7 to postpartum day 30. The results showed as follows:1) there was no significant difference in body weight of ewes among all groups (P>0.05). On postpartum day 5, 9 and 15, the milk yield of ewes in Trp group was lower than that in the control group (P>0.05); on postpartum day 9 and 15, the milk yield of ewes in 5-HTP group was higher than that in the control group (P>0.05). On postpartum day 16 to 30, the average daily gain of lambs in 5-HTP group was significantly higher than that in the control group (P<0.05). 2) On postpartum day 15, the plasma and milk calcium concentration in Trp group was significantly higher than that in the control group (P<0.05); on postpartum day 3, 6 and 15, the plasma and milk calcium concentration in 5-HTP group was significantly higher than that in the control group (P<0.05). On postpartum day 6, the plasma 5-HT concentration in Trp group was significantly higher than that in the control group (P<0.05); on postpartum day 30, the milk 5-HT concentration in Trp group was significantly higher than that in the control group (P<0.05); on postpartum day 6, 9 and 30, the plasma and milk 5-HT concentration in 5-HTP group was significantly higher than that in the control group (P<0.05). On postpartum day 3, 6 and 15, the plasma parathyroid hormone-related protein (PTHrP) concentration in Trp group and 5-HTP group was significantly higher than that in the control group (P<0.05). In conclusion, perfuse 5-HTP can promote the lactation of ewes, improve the average daily gain of lambs; perfuse 5-HTP and Trp can increase the concentration of calcium and 5-HT in plasma and milk and PTHrP in plasma.