刘事奇 , 胡睿智 , 李岩利 , 伍树松 . 牛磺酸维护肠道健康的潜在作用机理及其在畜禽生产中的应用[J]. 动物营养学报, 2019 , 31(11) : 5003 -5011 . DOI: 10.3969/j.issn.1006-267x.2019.11.014

[1] PION P D,KITTLESON M D,ROGERS Q R,et al.Myocardial failure in cats associated with low plasma taurine:a reversible cardiomyopathy[J].Science,1987,237(4816):764-768.  
[2] SILVA A L,WRIGHT S H.Short-term cell volume regulation in Mytilus californianus gill[J].Journal of Experimental Biology,1994,194(1):47-68.
[3] MIAO J F,ZHENG L H,ZHANG J Q,et al.The effect of taurine on the toll-like receptors/nuclear factor kappa B (TLRs/NF-κB) signaling pathway in Streptococcus uberis-induced mastitis in rats[J].International Immunopharmacology,2011,11(11):1740-1746.  
[4] ZHAI N H,WANG H,CHEN Y,et al.Taurine attenuates OTA-promoted PCV2 replication through blocking ROS-dependent autophagy via inhibiting AMPK/mTOR signaling pathway[J].Chemico-Biological Interactions,2018,296:220-228.
[5] MOCHIZUKI T,SATSU H,NAKANO T,et al.Regulation of the human taurine transporter by TNF-α and an anti-inflammatory function of taurine in human intestinal Caco-2 cells[J].BioFactors,2004,21(1/2/3/4):141-144.
[6] 李越.牛磺酸对育成期蛋鸭生长性能及血液生化指标的影响[D].硕士学位论文.哈尔滨:东北农业大学,2014.
[7] LU Z,HE X F,MA B B,et al.The alleviative effects and related mechanisms of taurine supplementation on growth performance and carcass characteristics in broilers exposed to chronic heat stress[J].Poultry Science,2019,98(2):878-886.  
[8] 张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪肠道黏膜抗氧化功能及胰蛋白酶活性的影响[J].畜牧与兽医,2018,50(11):35-39.
[9] 马娅君,张小龙,陈庆菊,等.牛磺酸对早期断奶仔猪生长性能和肠道健康的影响[J].动物营养学报,2018,30(10):4121-4131.
[10] 晏良超.牛磺酸对草鱼生产性能、肠道、鳃和机体健康及肉质的作用及其机制[D].硕士学位论文.雅安:四川农业大学,2017.
[11] MOTAWI T K,ELGAWAD H M A,SHAHIN N N.Modulation of indomethacin-induced gastric injury by spermine and taurine in rats[J].Journal of Biochemical and Molecular Toxicology,2010,21(5):280-288.
[12] O’FLAHERTY L,STAPLETON P P,REDMOND H P,et al.Intestinal taurine transport:a review[J].European Journal of Clinical Investigation,2015,27(11):873-880.
[13] 张小龙.牛磺酸对早期断奶仔猪生长性能和肠道发育的影响及机制[D].硕士学位论文.重庆:西南大学,2015.
[14] WOJCIK O P,KOENI K L,ZELENIUCH-JACQUOTTE A,et al.The potential protective effects of taurine on coronary heart disease[J].Atherosclerosis,2010,208(1):19-25.  
[15] HELLER-STILB B,VAN ROEYEN C,RASCHER K,et al.Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice[J].FASEB Journal,2002,16(2):231-233.  
[16] ITO T,KIMURA Y,UOZUMI Y,et al.Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy[J].Journal of Molecular and Cellular Cardiology,2008,44(5):927-937.  
[17] HAN X,PATTERS A B,JONES D P,et al.The taurine transporter:mechanisms of regulation[J].Acta Physiologica,2010,187(1/2):61-73.
[18] TAPPAZ M L.Taurine biosynthetic enzymes and taurine transporter:molecular identification and regulations[J].Neurochemical Research,2004,29(1):83-96.  
[19] 黄春喜,袁建敏,周向梅.牛磺酸对断奶小鼠小肠发育的影响[J].中国农业大学学报,2014,19(4):129-136.
[20] UNI Z,NOY Y,SKLAN D.Development of the small intestine in heavy and light strain chicks before and after hatching[J].British Poultry Science,1996,37(1):63-71.  
[21] 田芊芊,胡毅,毛盼,等.低鱼粉饲料中添加牛磺酸对青鱼幼鱼生长、肠道修复及抗急性拥挤胁迫的影响[J].水产学报,2016,40(9):1330-1339.
[22] SZABÒ H,FIORINO G,SPINELLI A,et al.Review article:anti-fibrotic agents for the treatment of Crohn’s disease-lessons learnt from other diseases[J].Alimentary Pharmacology and Therapeutics,2010,31(2):189-201.
[23] 黄春喜.牛磺酸对肉仔鸡和小鼠小肠发育的影响[D].硕士学位论文.北京:中国农业大学,2011.
[24] PARK Y K,MONACO M H,DONOVAN S M.Enteral insulin-like growth factor-Ⅰ augments intestinal disaccharidase activity in piglets receiving total parenteral nutrition[J].Journal of Pediatric Gastroenterology and Nutrition,1999,29(2):198-206.  
[25] SCHUIJERS J,JUNKER J P,MOKRY M,et al.Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts[J].Cell Stem Cell,2015,16(2):158-170.  
[26] 田黎明.β-catenin抗氧化应激所致人皮肤成纤维细胞衰老的机制研究[D].博士学位论文.长沙:中南大学,2011.
[27] KRAUSOVA M,KORINEK V.Wnt signaling in adult intestinal stem cells and cancer[J].Cellular Signalling,2014,26(3):570-579.  
[28] 张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪肠道吸收功能的影响[J].中国畜牧兽医,2010,37(8):20-22.
[29] HE X F,LU Z,MA B B,et al.Chronic heat stress damages small intestinal epithelium cells associated with the adenosine 5’-monophosphate-sctivated protein kinase pathway in broilers[J].Journal of Agricultural and Food Chemistry,2018,66(28):7301-7309.  
[30] TSUCHIOKA T,FUJIWARA T,SUNAGAWA M.Effects of glutamic acid and taurine on total parenteral nutrition[J].Journal of Pediatric Surgery,2006,41(9):1566-1572.  
[31] SON M W,KO J I,DOH H M,et al.Protective effect of taurine on TNBS-induced inflammatory bowel disease in rats[J].Archives of Pharmacal Research,1998,21(5):531-536.  
[32] OTTERBEIN L E,FORESTI R,MOTTERLINI R.Heme oxygenase-1 and carbon monoxide in the heart:the balancing act between danger signaling and pro-survival[J].Circulation Research,2016,118(12):1940-1959.  
[33] HE M H,PAN H,CHANG R C C,et al.Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage[J].PLoS One,2014,9(1):e84800.
[34] BEN-DOR A,STEINER M,GHEBER L,et al.Carotenoids activate the antioxidant response element transcription system[J].Molecular Cancer Therapeutics,2005,4(1):177-186.
[35] DOUGLAS S E,GALLANT J W,BULLERWELL C E.Molecular investigation of aminopeptidase N expression in the winter flounder,Pleuronectes americanus[J].Journal of Applied Ichthyology,2010,15(2):80-86.
[36] WAHNON R,COGAN U,MOKADY S.Dietary fish oil modulates the alkaline phosphatase activity and not the fluidity of rat intestinal microvillus membrane[J].The Journal of Nutrition,1992,122(5):1077-1084.  
[37] AHMAD M K,KHAN A A,ALI S N,et al.Chemoprotective effect of taurine on potassium bromate-induced DNA damage,DNA-protein cross-linking and oxidative stress in rat intestine[J].PLoS One,2015,10(3):e0119137.
[38] ELDOR R,ABEL R,SEVER D,et al.Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival[J].PLoS One,2013,8(2):e56924.
[39] 连淑君,王琳琳,唐清,等.牛磺酸对内毒素血症幼鼠肠屏障功能障碍的保护作用[J].临床儿科杂志,2010,28(10):950-954.
[40] 费东亮,王宏军,苏禹刚,等.牛磺酸对热应激肉鸡肠道SIgA和细胞因子的影响[J].饲料研究,2014(13):33-35,63.
[41] DU L L,YU Y Q,MA H Y,et al.Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1[J].International Journal of Molecular Sciences,2014,15(2):1983-2002.  
[42] ORRENIUS S,GOGVADZE V,ZHIVOTOVSKY B.Mitochondrial oxidative stress:implications for cell death[J].Annual Review of Pharmacology and Toxicology,2007,47(1):143-183.  
[43] BAMIAS G,KALTSA G,SIAKAVELLAS S I,et al.High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis[J].Clinical Immunology,2010,137(2):242-249.  
[44] GIRIS M,DEPBOYLU B,DOGRU-ABBASOGLU S,et al.Effect of taurine on oxidative stress and apoptosis-related protein expression in trinitrobenzene sulphonic acid-induced colitis[J].Clinical & Experimental Immunology,2008,152(1):102-110.  
[45] XIAO M,MI Y L,LIU L J,et al.Taurine regulates mucosal barrier function to alleviate lipopolysaccharide-induced duodenal inflammation in chicken[J].Amino Acids,2018,50(11):1637-1646.  
[46] HARHAJ N S,ANTONETTI D A.Regulation of tight junctions and loss of barrier function in pathophysiology[J].International Journal of Biochemistry & Cell Biology,2003,36(7):1206-1237.
[47] MARTÍNEZ C,GONZÁLEZ-CASTRO A,VICARIO M,et al.Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome[J].Gut and Liver,2012,6(3):305-315.  
[48] 王梦雅,高民,徐明,等.肌球蛋白轻链激酶介导肠黏膜上皮屏障功能变化的研究进展[J].动物营养学报,2018,30(12):4835-4841.
[49] BLAIR S A,KANE S V,CLAYBURGH D R,et al.Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease[J].Laboratory Investigation,2006,86(2):191-201.  
[50] YU H N,GUO Z Z,SHEN S R,et al.Effects of taurine on gut microbiota and metabolism in mice[J].Amino Acids,2016,48(7):1601-1617.  
[51] YANO J M,YU K,DONALDSON G P,et al.Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J].Cell,2015,161(2):264-276.  
[52] DOGRA S,SAKWINSKA O,SOH S E,et al.Rate of establishing the gut microbiota in infancy has consequences for future health[J].Gut Microbes,2015,6(5):321-325.  
[53] OMORI J,FUJIMORI S,KOSUGI Y,et al.Pilot study indicates Helicobacter pylori infection may induce small intestinal mucosal injury[J].Digestion,2019,99(1):66-71.  
[54] NOTO J M,PEEK R M,Jr.The gastric microbiome,its interaction with Helicobacter pylori,and its potential role in the progression to stomach cancer[J].PLoS Pathogens,2017,13(10):e1006573.
[55] 苏丹.慢性砷暴露对小鼠肠道菌群的影响及牛磺酸的作用[D].硕士学位论文.大连:大连医科大学,2017.
[56] ASARAT M,VASILJEVIC T,APOSTOLOPOULOS V,et al.Short-chain fatty acids regulate secretion of IL-8 from human intestinal epithelial cell lines in vitro[J].Immunological Investigations,2015,44(7):678-693.  
[57] BHUTIA Y D,GANAPATHY V.Short,but smart:SCFAs train T cells in the gut to fight autoimmunity in the brain[J].Immunity,2015,43(4):629-631.  
[58] LI H,ZHANG X G,FANG Q,et al.Supplemental effect of different levels of taurine in Modena on boar semen quality during liquid preservation at 17 ℃[J].Animal Science Journal,2017,88(11):1692-1699.  
[59] 张建斌,车向荣,陈娟娟.甘氨酰谷氨酰胺和牛磺酸对断奶仔猪抗氧化功能的影响[J].畜牧与兽医,2019,51(1):56-59.
[60] 陈钊,王明江,兰家暖,等.牛磺酸对夏季母猪哺乳期生产性能影响的研究[J].广西畜牧兽医,2017,33(5):252-253.
[61] LV Q F,SUN L,CUI Y Q,et al.Effects of replacement of methionine in diets with taurine on growth performance and blood index in broilers[M]//LEE D H, SCHAFFER S W, PARK E,et al.Taurine 10.Dordrecht:Springer,2017:989-1000.
[62] 王芙蓉.牛磺酸对鹌鹑生产性能、免疫功能及脂肪代谢影响的研究[D].博士学位论文.无锡:江南大学,2010.
[63] LU Z,HE X F,MA B B,et al.Dietary taurine supplementation improves breast meat quality in chronic heat-stressed broilers via activating the Nrf2 pathway and protecting mitochondria from oxidative attack[J].Journal of the Science of Food and Agriculture,2019,99(3):1066-1072.  
[64] 曾得寿,高振华,黄晓亮.牛磺酸对肉仔鸡屠宰性能和肌肉品质的影响[J].中国饲料,2011(17):21-23,28.
[65] 赵振升,位治国,杨帆,等.牛磺酸对海兰褐雏鸡抗氧化及免疫功能的影响[J].中国兽医科学,2015,45(8):867-872.
[66] MA Z L,GAO Y,MA H T,et al.Effects of taurine and housing density on renal function in laying hens[J].Journal of Zhejiang University(Science B),2016,17(12):952-964.