综述 Review

生鲜乳中二(口恶)英毒性作用及其机理

  • 王丽芳
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  • 内蒙古自治区农牧业科学院, 农业农村部农产品质量安全风险评估实验室(呼和浩特), 呼和浩特 010031
王丽芳(1975-),女,内蒙古托县人,研究员,博士,主要从事生鲜乳质量安全研究和风险评估。E-mail:wanglifang100008@163.com

收稿日期: 2019-09-17

  网络出版日期: 2020-04-16

基金资助

国家奶产品质量安全风险评估重大专项(GJFP2019026);内蒙古农牧业科学院创新基金(2017CXJJM09)

Dioxins: Toxicity and Mechanism in Raw Milk

  • WANG Lifang
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  • Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Laboratory of Quality&Safety Risk Assessment for Agricultural Products(Hohhot), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China

Received date: 2019-09-17

  Online published: 2020-04-16

Supported by

 

摘要

二(口恶)英是一类氯代含氧三环芳烃类持久性有机污染物,因为其特有的化学和物理特性,很容易在食物链中积累。二(口恶)英包含多氯二苯并对二(口恶)英(PCDDs)和多氯二苯并呋喃(PCDFs)两大类,其中2,3,7,8-四氯二苯并对二(口恶)英(TCDD)是毒性最强的一种。本文主要就生鲜乳中PCDDs和PCDFs的含量、来源及其中TCDD的毒性作用及其机理进行概述,为相关研究提供一定参考。

本文引用格式

王丽芳 . 生鲜乳中二(口恶)英毒性作用及其机理[J]. 动物营养学报, 2020 , 32(4) : 1465 -1472 . DOI: 10.3969/j.issn.1006-267x.2020.04.001

Abstract

Dioxins are a kind of persistent organic pollutants with chlorinated oxytricyclic aromatic hydrocarbons, which are typical compounds accumulating in the food chain due to their particular chemical and physical properties. Dioxins mainly contain polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), among them specially on congeners with chlorines in the 2,3,7,8-positions (TCDD) due to its highest toxicity. The PCDDs and PCDFs contents, sources and toxicity and mechanism of TCDD in raw milk were summarized in the paper, which provided some reference value for related researches.

参考文献

[1] COVACI A,RYAN J J,SCHEPENS P.Patterns of PCBs and PCDD/PCDFs in chicken and pork fat following a Belgian food contamination incident[J].Chemosphere,2002,47(2):207-217.  
[2] MALISCH R.Increase of the PCDD/F-contamination of milk,butter and meat samples by use of contaminated citrus pulp[J].Chemosphere,2000,40(9/10/11):1041-1053.
[3] HOOGENBOOM R,BOVEE T,PORTIER L,et al.The German bakery waste incident;use of a combined approach of screening and confirmation for dioxins in feed and food[J].Talanta,2004,63(5):1249-1253.  
[4] US EPA.Tetra-through octa-chlorinated dioxins and furans by isotope dilution HRGC/HRMS[R].Method 1613,Washington,D.C.:U.S. Environmental Protection Agency Office of Water,Engineering and Analysis Division,1994:1-86.
[5] 中华人民共和国国家卫生和计划生育委员会.GB 5009.205-2013食品中二(口恶)英及其类似物毒性当量的测定[S].北京:中国标准出版社,2013.
[6] HARRISON R O,CARLSON R E.An immunoassay for TEQ screening of dioxin/furan samples:current status of assay and applications development[J].Chemosphere,1997,34(5/6/7):915-928.
[7] ENGWALL M,BRUNSTRÖM B,NÄF C,et al.Levels of dioxin-like compounds in sewage sludge determined with a bioassay based on EROD induction in chicken embryo liver cultures[J].Chemosphere,1999,38(10):2327-2343.  
[8] MURK A J,LEGLER J,DENISON M S,et al.Chemical-activated luciferase gene expression (CALUX):a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water[J].Fundamental and Applied Toxicology,1996,33(1):149-160.  
[9] 常文保,王敏灿,张柏林,等.稀土螯合物探针及其在时间分辨荧光免疫分析中的应用[J].大学化学,1997,12(1):1-6.
[10] RAMOS L,ELJARRAT E,HERNÁNDEZ L M,et al.Levels of PCDDs and PCDFs in farm cow's milk located near potential contaminant sources in Asturias (Spain).Comparison with levels found in control,rural farms and commercial pasteurized cow's milks[J].Chemosphere,1997,35(10):2167-2179.  
[11] DURAND B,DUFOUR B,FRAISSE D,et al.Levels of PCDDs,PCDFs and dioxin-like PCBs in raw cow's milk collected in France in 2006[J].Chemosphere,2008,70(4):689-693.  
[12] KIM D G,KIM M,JANG J H,et al.Monitoring of environmental contaminants in raw bovine milk and estimates of dietary intakes of children in South Korea[J].Chemosphere,2013,93(3):561-566.  
[13] PIZARRO-ARÁNGUIZ N,GALBÁN-MALAGÓN C J,RUIZ-RUDOLPH P,et al.Occurrence,variability and human exposure to polychlorinated dibenzo-p-dioxins (PCDDs),polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in dairy products from Chile during the 2011-2013 survey[J].Chemosphere,2015,126:78-87.
[14] ROCHA D A M,TORRES J P M,REICHEL K,et al.Determination of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in Brazilian cow milk[J].Science of the Total Environment,2016,572:177-184.
[15] FVRST P,KRAUSE G H M,HEIN D,et al.PCDD/PCDF in cow's milk in relation to their levels in grass and soil[J].Chemosphere,1993,27(8):1349-1357.  
[16] SCHULER F,SCHMID P,SCHLATTER C.Transfer of airborne polychlorinated dibenzo-p-dioxins and dibenzofurans into dairy milk[J].Journal of Agricultural and Food Chemistry,1997,45(10):4162-4167.  
[17] APPELBE T W,SNIHUR N A,DINEEN C,et al.Point-to-point modelling:an application to Canada-Canada and Canada-United States long distance calling[J].Information Economics and Policy,1988,3(4):311-331.  
[18] HOOGENBOOM R L A P,KLOP A,HERBES R,et al.Carry-over of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in dairy cows fed smoke contaminated maize silage or sugar beet pulp[J].Chemosphere,2015,137:214-220.
[19] HOOGENBOOM L,HOFFER S,MENNEN M,et al.Dioxins formed during fires,a threat to the food chain?[J].Organohalogen Compd,2012,74(1):1600-1603.
[20] KOGEVINAS M.Human health effects of dioxins:cancer,reproductive and endocrine system effects[J].APMIS,2001,109(Suppl.103):S223-S232.
[21] 谭雪梅.宫内暴露TCDD对雄性子代生殖功能及睾丸细胞凋亡的影响及机制[D].硕士学位论文.郑州:郑州大学,2019.
[22] 殷俊.TCDD对大鼠睾丸间质细胞凋亡的影响及其机制[D].硕士学位论文.郑州:郑州大学,2017.
[23] ZHANG X L,JI M M,TAN X M,et al.Impairment of ovaries by 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) exposure in utero associated with BMP15 and GDF9 in the female offspring rat[J].Toxicology,2018,410:16-25.
[24] ZHANG X L,JI M M,TAN X M,et al.Role of epigenetic regulation of Igf2 and H19 in 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD)-induced ovarian toxicity in offspring rats[J].Toxicology Letters,2019,311:98-104.
[25] ORLOWSKA K,SWIGONSKA S,SADOWSKA A,et al.The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the proteome of porcine granulosa cells[J].Chemosphere,2018,212:170-181.
[26] JIN M H,LOU J,YU H H,et al.Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin promotes inflammation in mouse testes:the critical role of Klotho in Sertoli cells[J].Toxicology Letters,2018,295:134-143.
[27] 沈斌,施丽丽,董晶剑,等.二(口恶)英暴露对成年男性血清类固醇激素的影响[J].中国环境科学,2018,38(6):2345-2352.
[28] WU C C,YU S R,TAN Q X,et al.Role of AhR in regulating cancer stem cell-like characteristics in choriocarcinoma[J].Cell Cycle,2018,17(18):2309-2320.  
[29] MASOUDI S,HASSANZADEH A,FAZLI H R,et al.An increased level of aryl hydrocarbon receptor in patients with pancreatic cancer[J].Middle East Journal of Digestive Diseases,2019,11(1):38-44.
[30] VOGEL C F A,ISHIHARA Y,CAMPBELL C E,et al.A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth[J].Cancers,2019,11(5):589.
[31] YANG X X,KU T T,SUN Z D,et al.Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo[J].Toxicology Letters,2019,312:139-147.
[32] YAMAGUCHI M,HANKINSON O.2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses the growth of human colorectal cancer cells in vitro:implication of the aryl hydrocarbon receptor signaling[J].International Journal of Oncology,2019,54(4):1422-1432.
[33] DANJOU A M N,COUDON T,PRAUD D,et al.Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort[J].Environment International,2019,124:236-248.
[34] HERLIN M,FINNILA M A J,ZIOUPOS P,et al.New insights to the role of aryl hydrocarbon receptor in bone phenotype and in dioxin-induced modulation of bone microarchitecture and material properties[J].Toxicology and Applied Pharmacology,2013,273(1):219-226.  
[35] YU H T,DU Y X,ZHANG X L,et al.The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway[J].Toxicology and Applied Pharmacology,2014,280(3):502-510.  
[36] CEDERVALL T,LIND P M,SÄVENDAHL L.Expression of the aryl hydrocarbon receptor in growth plate cartilage and the impact of its local modulation on longitudinal bone growth[J].International Journal of Molecular Sciences,2015,16(4):8059-8069.
[37] FADER K A,NAULT R,RAEHTZ S,et al.2,3,7,8-tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice[J].Toxicology and Applied Pharmacology,2018,348:85-98.
[38] GAO L Y,WANG Y,YAO Y C,et al.2,3,7,8-tetrachlorodibenzo-p-dioxin mediated cleft palate by mouse embryonic palate mesenchymal cells[J].Archives of Oral Biology,2016,71:150-154.
[39] GAO L Y,ZHANG F Q,ZHAO W H,et al.LncRNA H19 and target gene-mediated cleft palate induced by TCDD[J].Biomedical and Environmental Sciences,2017,30(9):676-680.
[40] WANG C,YUAN X G,LIU C P,et al.Preliminary research on DNA methylation changes during murine palatogenesis induced by TCDD[J].Journal of Cranio-Maxillofacial Surgery,2017,45(5):678-684.  
[41] ZHANG W,ZHOU S S,GAO Y W,et al.Alterations in DNA methyltransferases and methyl-CpG binding domain proteins during cleft palate formation as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice[J].Molecular Medicine Reports,2018,17(4):5396-5401.
[42] 雷俊秋,邱林,丁雄辉,等.γ-氨基丁酸A型受体β3亚基在2,3,7,8-四氯二苯并二(口恶)英诱导胎鼠腭裂模型中表达的研究[J].中华口腔医学杂志,2019,54(5):328-334.
[43] NGHIEM G T,NISHIJO M,PHAM T N,et al.Adverse effects of maternal dioxin exposure on fetal brain development before birth assessed by neonatal electroencephalography (EEG) leading to poor neurodevelopment;a 2-year follow-up study[J].Science of the Total Environment,2019,667:718-729.
[44] OANH N T P,KIDO T,HONMA S,et al.Androgen disruption by dioxin exposure in 5-year-old Vietnamese children:decrease in serum testosterone level[J].Science of the Total Environment,2018,640-641:466-474.
[45] PANG C F,ZHU C H,ZHANG Y Y,et al.2,3,7,8-Tetrachloodibenzo-p-dioxin affects the differentiation of CD4 helper T cell[J].Toxicology Letters,2019,311:49-57.
[46] LI Y P,XIE H Q,ZHANG W L,et al.Type 3 innate lymphoid cells are altered in colons of C57BL/6 mice with dioxin exposure[J].Science of the Total Environment,2019,662:639-645.
[47] ZHA S J,SHI W,SU W H,et al.Exposure to 2,3,7,8-tetrachlorodibenzo-paradioxin (TCDD) hampers the host defense capability of a bivalve species,Tegillarca granosa[J].Fish & Shellfish Immunology,2019,86:368-373.
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