[1] SCOTT N A,ANDRUSAITE A,ANDERSEN P,et al.Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis[J].Science Translational Medicine,2018,10(464):eaao4755.
[2] CHEN J Z,VITETTA L.Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber[J].Clinical Colorectal Cancer,2018,17(3):e541-e544.
[3] PEREGO S,SANSONI V,BANFI G,et al.Sodium butyrate has anti-proliferative,pro-differentiating,and immunomodulatory effects in osteosarcoma cells and counteracts the TNFα-induced low-grade inflammation[J].International Journal of Immunopathology and Pharmacology,2018,32,doi:10.1177/0394632017752240.
[4] 赵冬冬,杨澜,郭宇荣,等.腹水综合征肉鸡空肠中LPS和短链脂肪酸的含量检测[J].山西农业科学,2019,47(5):913-915.
[5] MACIA L,TAN J,VIEIRA A T,et al.Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome[J].Nature Communications,2015,6(1):6734.
[6] SHEN H,LU Z Y,XU Z H,et al.Associations among dietary non-fiber carbohydrate,ruminal microbiota and epithelium G-protein-coupled receptor,and histone deacetylase regulations in goats[J].Microbiome,2017,5(1):123.
[7] TRAMONTANO M,ANDREJEV S,PRUTEANU M,et al.Nutritional preferences of human gut bacteria reveal their metabolic idiosyncrasies[J].Nature Microbiology,2018,3(4):514-522.
[8] VITAL M,HOWE C,TIEDJE M.Revealing the bacterial butyrate synthesis pathways by analyzing (meta) genomic data[J].mBio,2014,5(2):e00889.
[9] RIVIÈRE A,SELAK M,LANTIN D,et al.Bifidobacteria and butyrate-producing colon bacteria:importance and strategies for their stimulation in the human gut[J].Frontiers in Microbiology,2016,7:979.
[10] PARK J,KIM M,KANG S G,et al.Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway[J].Mucosal Immunology,2015,8(1):80-93.
[11] 万晓,王新颖,李宁.短链脂肪酸的研究进展[J].中华胃肠外科杂志,2015,18(9):958-960.
[12] CHAMBERS E S,MORRISON D J,FROST G.Control of appetite and energy intake by SCFA:what are the potential underlying mechanisms?[J].Proceedings of the Nutrition Society,2015,74(3):328-336.
[13] ROOKS M G,GARRETT W S.Gut microbiota,metabolites and host immunity[J].Nature Reviews Immunology,2016,16(6):341-352.
[14] LAUKOETTER M G,BRUEWER M,NUSRAT A.Regulation of the intestinal epithelial barrier by the apical junctional complex[J].Current Opinion in Gastroenterology,2006,22(2):85-89.
[15] XIONG H T,GUO B X,GAN Z S,et al.Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition[J].Scientific Reports,2016,6(1):27070.
[16] SINGH N,GURAV A,SIVAPRAKASAM S,et al.Activation of Gpr109a,receptor for niacin and the commensal metabolite butyrate,suppresses colonic inflammation and carcinogenesis[J].Immunity,2014,40(1):128-139.
[17] KELLY C J,ZHENG L,CAMPBELL E L,et al.Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function[J].Cell Host & Microbe,2015,17(5):662-671.
[18] GONÇALVES P,MARTEL F.Butyrate and colorectal cancer:the role of butyrate transport[J].Current Drug Metabolism,2013,14(9):994-1008.
[19] VALENZANO M C,DIGUILIO K,MERCADO J,et al.Remodeling of tight junctions and enhancement of barrier integrity of the CACO-2 intestinal epithelial cell layer by micronutrients[J].PLoS One,2015,10(7):e0133926.
[20] MIAO W,WU X J,WANG K,et al.Sodium butyrate promotes reassembly of tight junctions in Caco-2 monolayers involving inhibition of MLCK/MLC2 pathway and phosphorylation of PKCβ2[J].International Journal of Molecular Sciences,2016,17(10):1696.
[21] YAN H,AJUWON K M.Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway[J].PLoS One,2017,12(6):e0179586.
[22] 刁慧.猪肠道微生物与SCFAs对肠道结构和功能的影响及其机制[D].博士学位论文.雅安:四川农业大学,2017.
[23] 张亚南,李轩,陈慧子,等.丙酸钠对IPEC-J2细胞紧密连接及炎症细胞因子的影响[J].南京农业大学学报,2019,42(1):137-144.
[24] WRZOSEK L,MIQUEL S,NOORDINE M L,et al.
Bacteroides thetaiotaomicron and
Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent[J].BMC Biology,2013,11(1):61.
[25] LE POUL E,LOISON C,STRUYF S,et al.Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation[J].Journal of Biological Chemistry,2003,278(28):25481-25489.
[26] KIM C H.Microbiota or short-chain fatty acids:which regulates diabetes?[J].Cellular & Molecular Immunology,2018,15(2):88-91.
[27] D'SOUZA W N,DOUANGPANYA J,MU S,et al.Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses[J].PLoS One,2017,12(7):e0180190.
[28] SMITH P M,HOWITT M R,PANIKOV N,et al.The microbial metabolites,short-chain fatty acids,regulate colonic Treg cell homeostasis[J].Science,2013,341(6145):569-573.
[29] MASLOWSKI K M,VIEIRA A T,NG A,et al.Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43[J].Nature,2009,461(7268):1282-1286.
[30] TROMPETTE A,GOLLWITZER E S,YADAVA K,et al.Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis[J].Nature Medicine,2014,20(2):159-166.
[31] LI M,VAN ESCH B C A M,HENRICKS P A J,et al.The anti-inflammatory effects of short chain fatty acids on lipopolysaccharide-or tumor necrosis factor α-stimulated endothelial cells via activation of GPR41/43 and inhibition of HDACs[J].Frontiers in Pharmacology,2018,9:533.
[32] THANGARAJU M,CRESCI G A,LIU K B,et al.GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon[J].Cancer Research,2009,69(7):2826-2832.
[33] PARK J,GOERGEN C J,HOGENESCH H,et al.Chronically elevated levels of short-chain fatty acids induce T cell-mediated ureteritis and hydronephrosis[J].The Journal of Immunology,2016,196(5):2388-2400.
[34] ZHANG W H,JIANG Y,ZHU Q F,et al.Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens[J].British Poultry Science,2011,52(3):292-301.
[35] WEN Z S,LU J J,ZOU X T.Effects of sodium butyrate on the intestinal morphology and DNA-binding activity of intestinal nuclear factor-κB in weanling pigs[J].Journal of Animal and Veterinary Advances,2012,11(6):814-821.
[36] CHANG P V,HAO L M,OFFERMANNS S,et al.The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(6):2247-2252.
[37] ARPAIA N,CAMPBELL C,FAN X Y,et al.Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation[J].Nature,2013,504(7480):451-455.
[38] THORBURN A N,MCKENZIE C I,SHEN S,et al.Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites[J].Nature Communications,2015,6(1):7320.
[39] SCHILDERINK R,VERSEIJDEN C,DE JONGE W J.Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis[J].Frontiers in Immunology,2013,4:226.
[40] MURAKOSHI S,FUKATSU K,OMATA J,et al.Effects of adding butyric acid to PN on gut-associated lymphoid tissue and mucosal immunoglobulin a levels[J].Journal of Parenteral and Enteral Nutrition,2011,35(4):465-472.
[41] ATARASHI K,TANOUE T,OSHIMA K,et al.Treg induction by a rationally selected mixture of
Clostridia strains from the human microbiota[J].Nature,2013,500(7461):232-236.
[42] WU W,SUN M,CHEN F,et al.Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43[J].Mucosal Immunology,2017,10(4):946-956.
[43] KIM M,QIE Y Q,PARK J,et al.Gut microbial metabolites fuel host antibody responses[J].Cell Host & Microbe,2016,20(2):202-214.
[44] PETERSON L W,ARTIS D.Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J].Nature Reviews Immunology,2014,14(3):141-153.
[45] ABREU M T.Toll-like receptor signalling in the intestinal epithelium:how bacterial recognition shapes intestinal function[J].Nature Reviews Immunology,2010,10(2):131-144.
[46] LIU B,QIAN J M,WANG Q B,et al.Butyrate protects rat liver against total hepatic ischemia reperfusion injury with bowel congestion[J].PLoS One,2014,9(8):e106184.
[47] XIAO T F,WU S Y,YAN C,et al.Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-κB in colon cancer cell
in vitro[J].Oncology Letters,2018,16(4):4439-4447.
[48] WU J L,ZOU J Y,HU E D,et al.Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway[J].Immunology Letters,2017,190:169-176.
京公网安备 11010802041926号