综述 REVIEW

硫胺素对维持反刍动物瘤胃上皮屏障功能的作用

  • 彭阿龙 ,
  • 范曜天 ,
  • 张浩 ,
  • 王洪荣
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  • 扬州大学动物科学与技术学院, 扬州 225009
彭阿龙(1993-),男,安徽宿州人,硕士研究生,从事动物营养与饲料科学研究。E-mail:1179569611@qq.com

收稿日期: 2019-11-21

  网络出版日期: 2020-05-15

基金资助

国家自然科学基金(31872988);扬州大学高端人才支持计划(2016)

Effects of Thiamine on Maintaining Rumen Epithelial Barrier Function in Ruminants

  • PENG Along ,
  • FAN Yaotian ,
  • ZHANG Hao ,
  • WANG Hongrong
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  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2019-11-21

  Online published: 2020-05-15

摘要

高精料诱导的瘤胃酸中毒往往会引起上皮屏障的损伤,大量的研究已经表明硫胺素在缓解亚急性瘤胃酸中毒方面发挥着一定的作用,但发生酸中毒时添加硫胺素对于维持瘤胃上皮屏障功能方面的研究还不深入,因此,本文从亚急性瘤胃酸中毒引起的硫胺素缺乏与上皮损伤的关系以及添加硫胺素在维持瘤胃上皮屏障功能中的作用进行讨论,为硫胺素在酸中毒中的应用提供理论依据。

本文引用格式

彭阿龙 , 范曜天 , 张浩 , 王洪荣 . 硫胺素对维持反刍动物瘤胃上皮屏障功能的作用[J]. 动物营养学报, 2020 , 32(5) : 1997 -2002 . DOI: 10.3969/j.issn.1006-267x.2020.05.006

Abstract

Rumen acidosis induced by high concentrate diet often causes damage to the epithelial barrier. A large number of studies have shown that thiamine plays a certain role in alleviating subacute rumen acidosis. However, the study on the maintenance of rumen epithelial barrier function by adding thiamine during acidosis is not in depth. Therefore, this paper discusses the relationship between thiamine deficiency and epithelial damage caused by subacute rumen acidosis and the role of thiamine in maintaining rumen epithelial barrier function, so as to provide theoretical basis for the application of thiamine in acidosis.

参考文献

[1] PLAIZIER J C,KRAUSE D O,GOZHO G N,et al.Subacute ruminal acidosis in dairy cows:the physiological causes,incidence and consequences[J].The Veterinary Journal,2008,176:21-31.
[2] STEELE M A,CROOM J,KAHLER M,et al.Bovine rumen epithelium undergoes rapid structural adaptations during grain-induced subacute ruminal acidosis[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2011,300(6):R1515-R1523.
[3] MILLER B L,MEISKE J C,GOODRICH R D.Effects of grain source and concentrate level on B-vitamin production and absorption in steers[J].Journal of Animal Science,62(2):473-483.
[4] SILVERMAN M,WERKMAN C H.Adaptation of the propionic-acid bacteria to vitamin B1 synthesis including a method of assay[J].Journal of Bacteriology,1939,38(1):25-32.  
[5] PAN X H,YANG L,BECKERS Y,et al.Thiamine supplementation facilitates thiamine transporter expression in the rumen epithelium and attenuates high-grain-induced inflammation in low-yielding dairy cows[J].Journal of Dairy Science,2017,100(7):5329-5342.  
[6] WEN L M,FENG L,JIANG W D,et al.Thiamin deficiency induces impaired fish gill immune responses,tight junction protein expression and antioxidant capacity:roles of the NF-κB,TOR,p38 MAPK and Nrf2 signaling molecules[J].Fish & Shellfish Immunology,2016,51:373-383.
[7] 王龙.硫胺素对犊牛瘤胃组织形态及其生长发育影响的研究[D].硕士学位论文.扬州:扬州大学,2013.
[8] ULLUWISHEWA D,ANDERSON R C,MCNABB W C,et al.Regulation of tight junction permeability by intestinal bacteria and dietary components[J].The Journal of Nutrition,2011,141(5):769-776.  
[9] ALEXANDER C,RIETSCHEL E T.Bacterial lipopolysaccharides and innate immunity[J].Journal of Endotoxin Research,2001,7(3):167-202.
[10] CALDERÓN-OSPINA C A,NAVA-MESA M O.B Vitamins in the nervous system:current knowledge of the biochemical modes of action and synergies of thiamine,pyridoxine,and cobalamin[J].CNS Neuroscience & Therapeutics,2019,26(1):5-13.
[11] NERI M,CANTATORE S,POMARA C,et al.Immunohistochemical expression of proinflammatory cytokines IL-1β,IL-6,TNF-α and involvement of COX-2,quantitatively confirmed by Western blot analysis,in Wernicke's encephalopathy[J].Pathology-Research and Practice,2011,207(10):652-658.  
[12] BEAUCHESNE E,DESJARDINS P,HAZELL A S,et al.Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain[J].Neurochemistry International,2009,55(5):275-281.  
[13] HAZELL A S,BUTTERWORTH R F.Update of cell damage mechanisms in thiamine deficiency:focus on oxidative stress,excitotoxicity and inflammation[J].Alcohol and Alcoholism,2009,44(2):141-147.  
[14] PAGE G L J,LAIGHT D,CUMMINGS M H.Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease[J].International Journal of Clinical Practice,2011,65(6):684-690.  
[15] PENNER G B,OBA M,GÄBEL G,et al.A single mild episode of subacute ruminal acidosis does not affect ruminal barrier function in the short term[J].Journal of Dairy Science,2010,93(10):4838-4845.  
[16] GAEBEL G,MARTENS H,BELL M.The effect of low mucosal pH on sodium and chloride movement across the isolated rumen mucosa of sheep[J].Quarterly Journal of Experimental Physiology,1989,74(1):35-44.  
[17] 冯仰廉.反刍动物营养学[M].北京:科学出版社,2004.
[18] PINLOCHE E,MCEWAN N,MARDEN J P,et al.The effects of a probiotic yeast on the bacterial diversity and population structure in the rumen of cattle[J].PLoS One,2013,8(7):e67824.
[19] 张红伟.硫胺素(VB1)对瘤胃内营养物质消化代谢的影响[D].硕士学位论文.扬州:扬州大学,2010.
[20] 董淑红.硫胺素对山羊瘤胃代谢的影响及其与亚急性瘤胃酸中毒关系的研究[D].硕士学位论文,扬州:扬州大学,2011.
[21] 潘晓花.硫胺素对SARA状态下奶牛瘤胃发酵及瘤胃菌群结构的影响[D].硕士学位论文.扬州:扬州大学,2013.
[22] PAN X H,XUE F G,NAN X M,et al.Illumina sequencing approach to characterize thiamine metabolism related bacteria and the impacts of thiamine supplementation on ruminal microbiota in dairy cows fed high-grain diets[J].Frontiers in Microbiology,2017,8:1818.
[23] XUE F G,NAN X M,SUN F Y,et al.Metagenome sequencing to analyze the impacts of thiamine supplementation on ruminal fungi in dairy cows fed high-concentrate diets[J].AMB Express,2018,8(1):159.
[24] XUE F G,PAN X H,JIANG L S,et al.GC-MS analysis of the ruminal metabolome response to thiamine supplementation during high grain feeding in dairy cows[J].Metabolomics,2018,14:67.
[25] 刘军花.亚急性瘤胃酸中毒对山羊瘤胃上皮屏障功能的影响及其机制[D].硕士学位论文.南京:南京农业大学,2014.
[26] ZHANG H,PENG A L,ZHAO F F,et al.Thiamine ameliorates inflammation of the ruminal epithelium of Saanen goats suffering from subacute ruminal acidosis[J].Journal of Dairy Science,2019,103(2):1931-1943.
[27] MOLINA P E,FAN J,BOXER R,et al.Modulation of insulin-like growth factor-Ⅰ:a specific role for vitamin B1 (thiamine)[J].The Journal of Nutritional Biochemistry,1996,7(4):207-213.  
[28] STEELE M A,ALZAHAL O,WALPOLE M E,et al.Short communication:grain-induced subacute ruminal acidosis is associated with the differential expression of insulin-like growth factor-binding proteins in rumen papillae of lactating dairy cattle[J].Journal of Dairy Science,2012,95(10):6072-6076.  
[29] BALDWIN R L.The proliferative actions of insulin,insulin-like growth factor-Ⅰ,epidermal growth factor,butyrate and propionate on ruminal epithelial cells in vitro[J].Small Ruminant Research,1999,32(3):261-268.  
[30] EMMANUEL D G V,DUNN S M,AMETAJ B N.Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows[J].Journal of Dairy Science,2008,91(2):606-614.  
[31] DENG Y X,CUI H M,PENG X,et al.Effect of dietary vanadium on cecal tonsil T cell subsets and IL-2 contents in broilers[J].Biological Trace Element Research,2011,144(1/2/3):647-656.
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