综述 REVIEW

氧化应激对畜禽组织器官的损伤及核因子E2相关因子2-抗氧化反应元件信号通路抗氧化应激的机理研究进展

  • 赵雅丽 ,
  • 张心壮 ,
  • 格日乐其木格 ,
  • 芒来
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  • 1. 内蒙古农业大学动物科学学院, 内蒙古自治区马属动物遗传育种与繁殖学重点实验室, 农业农村部马属动物遗传育种与繁殖科学观测实验站, 呼和浩特 010018;
    2. 内蒙古农业大学马属动物研究中心, 呼和浩特 010018
赵雅丽(1996-),女,内蒙古通辽人,硕士研究生,研究方向为马属动物营养。E-mail:2090164677@qq.com

收稿日期: 2019-10-17

  网络出版日期: 2020-05-15

基金资助

国家自然科学基金项目(31902188);内蒙古农业大学高层次引进人才启动项目(NDGCC2016-01);内蒙古农业大学动物科学学院青年基金项目(QN201917);科技部国际合作项目(2017YFE0108700)

Research Progress of Oxidative Stress Damage on Livestock Tissues and Organs Associated with Antioxidative Stress Mechanism of Nuclear Factor E2 Related Factor 2-Antioxidant Response Element Signaling Pathway

  • ZHAO Yali ,
  • ZHANG Xinzhuang ,
  • Gerelchimeg ,
  • Manglai
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  • 1. Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, Scientific Observing and Experimental Station of Equine Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
    2. Equine Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2019-10-17

  Online published: 2020-05-15

摘要

随着我国养殖业的发展,养殖方式逐渐向规模化集约化转变,对畜禽生产性能的要求越来越高,但是在追求养殖效率的同时,畜禽饲养管理过程中易产生多种应激,如断奶应激、运输应激、热应激、冷应激等。大量的研究表明氧化应激是产生各种应激的根本原因。氧化应激可以破坏动物机体的氧化还原系统,导致肠道、肝脏、生殖器官等各种组织器官的损伤和疾病的发生,成为近年来研究的热点。而核因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号通路的激活可以维持动物机体的氧化平衡,提高抗氧化性能,缓解氧化应激。本文通过阐述氧化应激对畜禽组织器官的影响及其产生的机制,并就Nrf2-ARE信号通路抗氧化应激的机理进行综述,为畜禽生产过程中缓解氧化应激损伤、保障动物福利、提高动物的生产性能提供参考。

本文引用格式

赵雅丽 , 张心壮 , 格日乐其木格 , 芒来 . 氧化应激对畜禽组织器官的损伤及核因子E2相关因子2-抗氧化反应元件信号通路抗氧化应激的机理研究进展[J]. 动物营养学报, 2020 , 32(5) : 2052 -2059 . DOI: 10.3969/j.issn.1006-267x.2020.05.013

Abstract

The performance and production efficiency of livestock are improving with the development of the highly intensive and large-scale management in China. Whatever, a large amount of studies had demonstrated that oxidative stress was the rooted causes of those various kinds of stress such as weaning stress, transport stress, heat stress and cold stress, which are easier to occur in currently. Oxidative stress is harmful for the redox system of animal, leading to the damage and disease of various tissues and organs such as intestines, liver and reproductive organs. The activation of the nuclear factor E2 related factor 2(Nrf2)-antioxidant response element (ARE) signaling pathway could alleviate oxidative stress through maintaining the oxidative balance, improving the antioxidant property. The present paper summarizes the effects of oxidative stress on tissues and organs of livestock, and the antioxidative mechanism of Nrf2-ARE signaling pathway, in order to provide reference for alleviating oxidative stress damage, ensuring animal welfare and improving animal performance in livestock production.

参考文献

[1] TSIOURIS V,GEORGOPOULOU I,BATZIOS C,et al.The effect of cold stress on the pathogenesis of necrotic enteritis in broiler chicks[J].Avian Pathology,2015,44(6):430-435.  
[2] XU M,YU X Y,LI J L,et al.Effects of acute and chronic cold stress on antioxidant function in intestinal tracts of chickens[J].Journal of Northeast Agricultural University (English Edition),2012,19(2):54-61.  
[3] 黄思琪,曲红焱,黄大鹏,等.L-精氨酸对冷应激仔猪生长性能、免疫功能及肝脏、肾脏中肿瘤坏死因子-α、干扰素-γ基因表达量的影响[J].动物营养学报,2019,31(1):131-139.
[4] 王娜,姜晓文,王婕然,等.中药干预对冷应激雏鸡血液生化指标的影响[J].中兽医医药杂志,2018,37(2):11-14.
[5] 刘春朋,付晶.冷应激对雏鹌鹑胸腺组织抗氧化功能的影响[J].饲料博览,2018(8):40-42.
[6] WEN X,WU J M,WANG F T,et al.Deconvoluting the role of reactive oxygen species and autophagy in human diseases[J].Free Radical Biology and Medicine,2013,65:402-410.
[7] 崔艳军.热应激和氧化应激对肥育猪骨骼肌代谢的影响及硫辛酸的调控作用[D].博士学位论文.北京:中国农业科学院,2016:2-26.
[8] 钟光,邵丹,胡艳,等.持续热应激对黄羽肉鸡生长性能、器官指数、血清生化指标和抗氧化功能的影响[J].动物营养学报,2018,30(11):4425-4432.
[9] 刘秀楠,郭亮,郝慧,等.急性热应激对肉仔鸡抗氧化能力的影响[J].实验研究,2017(9):4-5.
[10] 徐建雄.不同断奶日龄仔猪的氧化应激损伤及其机理研究[D].博士学位论文.南京:南京农业大学,2014:20-26.
[11] ZHOU X,ZHANG Y,WU X,et al.Effects of dietary serine supplementation on intestinal integrity, inflammation and oxidative status in early-weaned piglets[J]. Cellular Physiology & Biochemistry,2018,48(3):993-1002.  
[12] 张林.运输应激对肉仔鸡肌肉品质的影响及其机理[D].硕士学位论文.杨凌:西北农林科技大学,2009:12-19.
[13] 尹佳佳,李耀华,单安山.γ-氨基丁酸对猪生长性能的影响和抗运输应激的作用[C]//中国畜牧兽医学会动物营养学分会第十一次全国动物营养学术研讨会论文集.长沙:中国畜牧兽医学会,2012.
[14] 刘延鑫,孙宇,李业亮,等.黄芪多糖缓解肉牛短途运输应激的效果研究[J].中国畜牧兽医,2017,44(1):87-93.
[15] 韩月,黄友解,王友明,等.氧化应激对动物肠道的危害及其营养学缓解措施[J].上海畜牧兽医通讯,2017(4):44-49.
[16] BOROS M,TAKAICHI S,HATANAKA K.Ischemic time-dependent microvascular changes and reperfusion injury in the rat small intestine[J].Journal of Surgical Rescarch,1995,59(2):311-320.  
[17] 林厦菁,蒋守群,丁发源,等.大豆异黄酮与芽孢杆菌对缓解黄羽肉仔鸡肠道氧化应激的影响[J].中国家禽,2015,37(19):20-25.
[18] WU B Y,CUI H M,PENG X,et al.Dietary nickel chloride induces oxidative intestinal damage in broilers[J].International Journal of Environmental Research and Public Health,2013,10(6):2109-2119.  
[19] GOU Z Y,LI L,FAN Q L,et al.Effects of oxidative stress induced by high dosage of dietary iron ingested on intestinal damage and caecal microbiota in Chinese yellow broilers[J].Journal of Animal Physiology and Animal Nutrition,2018,102(4):924-932.  
[20] YU J,YAO H D,GAO X J,et al.The role of nitric oxide and oxidative stress in intestinal damage induced by selenium deficiency in chickens[J].Biological Trace Element Research,2015,163(1/2):144-153.
[21] 郭志有.α-硫辛酸对肉鸡抗氧化的影响及其作用机制研究[D].博士学位论文.南京:南京农业大学,2014:106-128.
[22] 侯洪涛,裘艳梅,冯佳,等.姜黄素对非酒精性脂肪肝病大鼠肠道sIgA及氧化应激的影响[J].广东医学,2018,39(8):1133-1136.
[23] 王啸春,陈小连,赵珂立,等.动物肠道氧化应激及抗氧化剂干预作用研究进展[J].中国畜牧杂志,2011,47(11):73-78.
[24] 刘东鑫,余功富,金洁瑜,等.合成抗氧化剂对断奶犊牛抗氧化干预的研究进展[J].中国畜牧杂志,2018,54(9):5-9.
[25] 赵娇.葡萄籽原花青素缓解氧化应激仔猪肝脏损伤及可能机制研究[D].硕士学位论文.雅安:四川农业大学,2013:30-52.
[26] 王菲.锌对热暴露小鼠和巴马香猪肝脏氧化应激的影响[D].硕士学位论文.南京:南京农业大学,2015:33-64.
[27] 谢永新,史延,黄利华,等.急性冷、热应激对肉鸡肝脏和心脏组织中HSPs表达的影响[J].中国家禽,2018,40(1):7-11.
[28] LIN H,DECUYPERE E,BUYSE J.Acute heat stress induces oxidative stress in broiler chickens[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2006,144(1):11-17.  
[29] POERSCH A B,TROMBETTA F,BRAGA A C M,et al.Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks[J].Veterinary Microbiology,2014,174(1/2):180-185.
[30] LI X T,REHMAN M U,MEHMOOD K,et al.Ameliorative effects of nano-elemental selenium against hexavalent chromium-induced apoptosis in broiler liver[J].Environmental Science and Pollution Research,2018,25(16):15609-15615.  
[31] LIU C P,FU J,LIU C,et al.The role of nitric oxide and autophagy in liver injuries induced by selenium deficiency in chickens[J].RSC Advances,2015,5(62):50549-50556.  
[32] 范文韬.口服三价铬诱导鸡肝脏氧化应激和损伤的研究[D].硕士学位论文.泰安:山东农业大学,2016:28-40.
[33] LIU X T,LIN X,MI Y L,et al.Grape seed proanthocyanidin extract prevents ovarian aging by inhibiting oxidative stress in the hens[J].Oxidative Medicine and Cellular Longevity,2018,2018:9390810.
[34] TALUKDER S,INGENHOFF L,KERRISK K L,et al.Plasma oxidative stress biomarkers and progesterone profiles in a dairy cow diagnosed with an ovarian follicular cyst[J].Veterinary Quarterly,2014,34(2):113-117.  
[35] CELI P,MERLO M,DA DALT L,et al.Relationship between late embryonic mortality and the increase in plasma advanced oxidised protein products (AOPP) in dairy cows[J].Reproduction,Fertility and Development,2011,23(4):527-533.  
[36] BALL B.The Effect of oxidative stress on equine sperm function,semen storage and stallion fertility[J].Journal of Equine Veterinary Science,2000,20(2):95-96.  
[37] LI Y S,WANG A H,TAYA K,et al.Declining semen quality and steadying seminal plasma ions in heat-stressed boar model[J].Reproductive Medicine and Biology,2015,14(4):171-177.  
[38] 李延森,李照见,贾潇潇,等.环境高温诱导巴马香猪睾丸细胞凋亡并激活Nrf2/HO-1抗氧化信号通路[J].畜牧兽医学报,2018,49(6):1154-1162.
[39] HÄRTLOVÁ H,RAJMON R,KRONTORÁDOVÁ I,et al.Semen quality,lipid peroxidation,and seminal plasma antioxidant status in horses with different intensities of physical exercise[J].Acta Veterinaria Brno,2013,82(1):31-35.  
[40] KRYSTON T B,GEORGIEV A B,PISSIS P,et al.Role of oxidative stress and DNA damage in human carcinogenesis[J].Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis,2011,711:193-201.
[41] 刘力坤,欧阳伟炜,苏胜发,等.DNA损伤及氧化应激在放射性心脏损伤中的作用[J].科技导报,2017,35(4):74-78.
[42] 周阳,严丽荣,袁少飞,等.氧化应激与阿尔茨海默病[J].生命科学研究,2015,19(3):265-275.
[43] 李春玲,吴康,范小勇.氧化应激与结核病[J].生命科学,2017,29(11):1108-1112.
[44] 谷娟,张春刚,刘祯,等.氧化应激与奶牛围产期疾病的关系及其作用机制[J].中国奶牛,2015(10):31-35,36.
[45] 王向明,刘宇宸,高景,等.氧化应激与奶牛肢蹄病关系的研究进展[J].中国奶牛,2018(10):39-43.
[46] 云博,吴景东.氧化应激与相关疾病及其作用机制[J].沈阳医学院学报,2018,20(3):272-276.
[47] 李航,段惠军.Nrf2/ARE信号通路及其调控的抗氧化蛋白[J].中国药理学通报,2011,27(3):300-303.
[48] 蔡旗旗,卢中秋.Keap l-Nrf2/ARE化学通路在抗氧化过程中的作用[J].浙江医学,2010,32(7):1113-1116.
[49] 吴志红,马燕芬,赵磊,等.Nrf2-ARE信号通路在机体氧化应激损伤中的作用及与其他信号通路的关系[J].畜牧与饲料科学,2016,37(3):42-48.
[50] 童海达,王佳茗,宋英.Keap l-Nrf2-ARE在机体氧化应激损伤中的防御作用[J].癌变·畸变·突变,2012,25(1):71-75.
[51] 王宁,马慧萍,漆欣筑,等.Nrf2-ARE信号通路在机体氧化应激损伤防护中的研究进展[J].解放军医药杂志,2015,27(12):21-27.
[52] LEE M T,LIN W C,WANG S Y,et al.Evaluation of potential antioxidant and anti-inflammatory effects of Antrodia cinnamomea powder and the underlying molecular mechanisms via Nrf2- and NF-κB-dominated pathways in broiler chickens[J].Poultry Science,2018,97(7):2419-2434.  
[53] ZHANG J F,BAI K W,SU W P,et al.Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase Ⅱ detoxifying enzyme systems in broiler chickens[J].Poultry Science,2018,97(4):1209-1219.  
[54] SHI H Y,YAN S M,GUO Y M,et al.Vitamin A pretreatment protects NO-induced bovine mammary epithelial cells from oxidative stress by modulating Nrf2 and NF-κB signaling pathways[J].American Society of Animal Science,2018,96(4):1305-1316.
[55] MENG Q W,GUO T,LI G Q,et al.Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1[J].Journal of Animal Science and Biotechnology,2018,9:34.
[56] 黄汉昌.路书彦,常平,等.Nrf2-ARE信号通路参与姜黄素对Aβ诱导细胞氧化损伤和凋亡的抑制作用研究[J].现代食品科技,2015,31(6):1-5,43.
[57] 叶舒.白藜芦醇对FLHS蛋鸡肝脏氧化应激及炎症的调控作用[D].硕士学位论文.南昌:江西农业大学,2017:18-28.
[58] CHENG X,YANG S H,XU C,et al.Proanthocyanidins protect against β-hydroxybutyrate-induced oxidative damage in bovine endometrial cells[J].Molecules,2019,24(3):E400.
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