综述 REVIEW

细菌脲酶抑制剂及其作用机理的研究进展

  • 张震宇 ,
  • 赵圣国 ,
  • 郑楠 ,
  • 王加启
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  • 1. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    2. 中国农业科学院 北京畜牧兽医研究所, 农业部奶及奶制品质量安全控制重点实验室, 北京 100193
张震宇(1996-),男,江西南昌人,硕士研究生,研究方向为反刍动物营养与饲料科学。E-mail:zzy123779@126.com

收稿日期: 2020-01-09

  网络出版日期: 2020-08-13

基金资助

国家自然科学基金项目(31430081);现代农业产业技术体系专项(CARS-36);中国农业科学院农业科技创新工程重大产出科研选题(CAAS-ZDXT2019004);中国农业科学院科技创新工程(ASTIP-IAS12)

Research Progress in Urease Inhibitors and Its Mechanism

  • ZHANG Zhenyu ,
  • ZHAO Shengguo ,
  • ZHENG Nan ,
  • WANG Jiaqi
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  • 1. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Key Laboratory of Quality and Safety Control for Milk and Dairy Products, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-01-09

  Online published: 2020-08-13

摘要

脲酶抑制剂能有效抑制细菌脲酶活性,降低尿素分解菌产生氨的速度,广泛应用于医药及农业领域。然而,目前使用的脲酶抑制剂存在着生物毒性强、微生物适应性与稳定性差等问题,限制了脲酶抑制剂的应用。近年来,研究发现了一系列新的脲酶抑制先导化合物,同时报道了这些化合物的脲酶抑制结构以及作用模式与机制。本文综述了近10年有关脲酶抑制剂的报道,并对所报道的脲酶抑制剂进行系统分类,以探讨不同类别的脲酶抑制剂的构效关系、抑制效果与抑制模式,并从不同类型脲酶抑制剂的构效关系探讨了其作用机理,旨在为新型脲酶抑制剂的开发提供参考。

本文引用格式

张震宇 , 赵圣国 , 郑楠 , 王加启 . 细菌脲酶抑制剂及其作用机理的研究进展[J]. 动物营养学报, 2020 , 32(8) : 3496 -3508 . DOI: 10.3969/j.issn.1006-267x.2020.08.007

Abstract

Urease inhibitors suppress urease activity, consequently lower the rate of ureolytic process between the urease producing bacteria and urea. Urease inhibitor has been widely implemented in both agriculture and medical area. But the existing bacterial urease inhibitor holds a lot of downsides such as toxicity, microbial adaptation, and compromised stability. These problems limit the application of urease inhibitors. In recent years, a lot of novel urease inhibitors have been found and its motifs and substructures bearing urease inhibition capacity have been revealed. The related interaction mode and mechanism have also been demonstrated. This article reviews urease inhibitors reported in the past ten years; arranges them in different groups and discusses the structure-activity relationship, inhibition effectiveness, and inhibition mode of individual groups. The inhibition mechanism was discussed from the perspective of structure-activity relationship of different types of urease inhibitors. This article may serve as useful reference for future discovery of novel urease inhibitor.

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