综述 REVIEW

蛋氨酸及其一碳代谢产物促进肠道上皮更新机制的研究进展

  • 刘振华 ,
  • 周加义 ,
  • 张得香 ,
  • 王修启
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  • 华南农业大学动物科学学院, 广东省动物营养调控重点实验室, 国家生猪种业工程技术研究中心, 广州 510642
刘振华(1991-),男,河南项城人,硕士研究生,从事动物营养与饲料科学研究。E-mail:1477951794@qq.com

收稿日期: 2020-01-17

  网络出版日期: 2020-08-13

基金资助

国家自然科学基金面上项目(31872389)

Research Advances in Mechanism of Methionine and Its Carbon Metabolites Promoting Intestinal Epithelial Renewal

  • LIU Zhenhua ,
  • ZHOU Jiayi ,
  • ZHANG Dexiang ,
  • WANG Xiuqi
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  • National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China

Received date: 2020-01-17

  Online published: 2020-08-13

摘要

肠道干细胞的更新和再生是维持肠上皮高度活跃性和可塑性的关键,并受肠腔中各种营养素的直接调控。蛋氨酸作为一种必需的膳食分子,具有促进肠细胞蛋白质合成、增强肠上皮屏障功能、控制肠细胞氧化状态和调节肠黏膜免疫反应等功能。蛋氨酸或其一碳代谢产物S-腺苷甲硫氨酸的缺失,会通过下调Wnt/β-连环蛋白和哺乳动物雷帕霉素靶蛋白敏感型复合体1(mTORC1)等信号转导途径抑制肠道干细胞分裂,致使肠上皮形态和功能紊乱。本文就蛋氨酸的吸收和代谢过程,及其对肠道黏膜屏障功能和肠道干细胞增殖分化的影响作一综述,旨在为蛋氨酸调控肠道更新和再生的临床和生产应用提供参考。

本文引用格式

刘振华 , 周加义 , 张得香 , 王修启 . 蛋氨酸及其一碳代谢产物促进肠道上皮更新机制的研究进展[J]. 动物营养学报, 2020 , 32(8) : 3552 -3559 . DOI: 10.3969/j.issn.1006-267x.2020.08.013

Abstract

The renewal and regeneration of intestinal stem cells is the key to maintain the high activity and plasticity of the intestinal epithelium and is directly regulated by various nutrients in the intestinal lumen. As an essential dietary molecule, methionine can promote protein synthesis, enhance intestinal epithelial barrier function, control intestinal cell oxidation and regulate the intestinal mucosal immune response. The absence of methionine or one of its carbon metabolites-S-adenosylmethionine, inhibits intestinal stem cell division by downregulating Wnt/β-catenin and mammalian target-sensitive complex of rapamycin 1 (mTORC1) signaling pathways, and results in morphological and functional disorders of the intestinal epithelium. In this paper, we review the absorption and metabolism of methionine and its effect on intestinal mucosal barrier function and intestinal stem cell proliferation and differentiation, to provide a reference for the clinical and production application of methionine in regulating intestinal renewal and regeneration.

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