综述 REVIEW

断奶仔猪肠道菌群结构特征及其调控研究进展

  • 王文文 ,
  • 王园 ,
  • 安晓萍 ,
  • 齐景伟
展开
  • 1. 内蒙古农业大学动物科学学院, 呼和浩特 010018;
    2. 内蒙古自治区草食家畜饲料工程技术研究中心, 呼和浩特 010018
王文文(1993-),女,内蒙古呼和浩特人,博士研究生,从事生物饲料的研发与应用研究。E-mail:wangwenwen2017@emails.imau.edu.cn

收稿日期: 2020-03-31

  网络出版日期: 2020-11-16

基金资助

国家自然科学基金项目(31601969);内蒙古自治区研究生科研创新项目(S2018111985Z);内蒙古农业大学"双一流"学科创新人才培养计划项目(NDSC2018-04);内蒙古自治区科技重大专项(ZD20190039)

Research Advances on Structural Characteristics and Modulation of Gut Microbiota of Weaned Piglets

  • WANG Wenwen ,
  • WANG Yuan ,
  • AN Xiaoping ,
  • QI Jingwei
Expand
  • 1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
    2. Inner Mongolia Herbivorous Livestock Feed Engineering and Technology Research Center, Hohhot 010018, China

Received date: 2020-03-31

  Online published: 2020-11-16

摘要

仔猪断奶腹泻是由断奶应激引起的一系列复杂生理变化所致,是导致仔猪死亡的主要原因。大量研究显示,肠道菌群结构紊乱普遍发生于腹泻仔猪中,通过调节肠道菌群结构可以缓解仔猪断奶腹泻。因此,本文就断奶前后仔猪肠道菌群结构变化、断奶腹泻仔猪肠道菌群结构特征及其调控措施进行了综述,以期为缓解和阻止仔猪断奶腹泻提供理论参考。

本文引用格式

王文文 , 王园 , 安晓萍 , 齐景伟 . 断奶仔猪肠道菌群结构特征及其调控研究进展[J]. 动物营养学报, 2020 , 32(11) : 4998 -5005 . DOI: 10.3969/j.issn.1006-267x.2020.11.003

Abstract

Post-weaning diarrhea is caused by a series of complex physiological changes caused by weaning stress, which is a major cause of mortality. A large number of studies have shown that there is a gut microbial disorder in diarrhea piglets, and post-weaning diarrhea can be alleviated though modulating gut microbiota composition. Therefore, this review focused on changes of gut microbiota structure in the pre-weaning and post-weaning period, the structural characteristics of gut microbiota in the post-weaning diarrhea of piglet and regulation of gut microbiota, in order to provide theoretical reference for alleviating and preventing post-weaning diarrhea.

参考文献

[1] VOGT S L,FINLAY B B.Gut microbiota-mediated protection against diarrheal infections[J].Journal of Travel Medicine,2017,24(Suppl.1):S39-S43.
[2] GILBERT J A,BLASER M J,CAPORASO J G,et al.Current understanding of the human microbiome[J].Nature Medicine,2018,24(4):392-400.  
[3] LOPETUSO L R,SCALDAFERRI F,PETITO V,et al.Commensal clostridia:leading players in the maintenance of gut homeostasis[J].Gut Pathogens,2013,5:23.
[4] ADIBI S A.The oligopeptide transporter (Pept-1) in human intestine:biology and function[J]. Gastroenterology,1997,113(1):332-340..  
[5] WANG Z,ZENG X M,MO Y M,et al.Identification and characterization of a bile salt hydrolase from Lactobacillus salivarius for development of novel alternatives to antibiotic growth promoters[J].Applied and Environmental Microbiology,2012,78(24):8795-8802.  
[6] NG K M,FERREYRA J A,HIGGINBOTTOM S K,et al.Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens[J].Nature,2013,502(7469):96-99.  
[7] NAGAO-KITAMOTO H,LESLIE J L,KITAMOTO S,et al.Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota[J].Nature Medicine,2020,26(4):608-617.  
[8] KOMMINENI S,BRETL D J,LAM V,et al.Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract[J].Nature,2015,526(7575):719-722.  
[9] BUFFIE C G,BUCCI V,STEIN R R,et al.Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile[J].Nature,2015,517(7533):205-208.  
[10] RUSSELL A B,WEXLER A G,HARDING B N,et al.A type Ⅵ secretion-related pathway in Bacteroidetes mediates interbacterial antagonism[J].Cell Host & Microbe,2014,16(2):227-236.  
[11] 胡军.利用贵州从江香猪资源发掘早期断奶仔猪腹泻抗性相关肠道微生物及其作用机制研究[D].博士学位论文.武汉:华中农业大学,2019.
[12] KONSTANTINOV S R,AWATI A A,WILLIAMS B A,et al.Post-natal development of the porcine microbiota composition and activities[J].Environmental Microbiology,2006,8(7):1191-1199.  
[13] WELLOCK I J,FORTOMARIS J G,HOUDIJK J G M,et al.The effect of dietary protein supply on the performance and risk of post-weaning enteric disorders in newly weaned pigs[J].Animal Science Journal,2007,82:327-335.
[14] PAJARILLO E A B,CHAE J P,BALOLONG M P,et al.Assessment of fecal bacterial diversity among healthy piglets during the weaning transition[J].The Journal of General and Applied Microbiology,2014,60(4):140-146.  
[15] ALUTHGE N D,VAN SAMBEEK D,CARNEY-HINKLE E E,et al.Board invited review:the pig microbiota and the potential for harnessing the power of the microbiome to improve growth and health[J].Journal of Animal Science,2019,97(9):3741-3757.  
[16] GUEVARRA R B,LEE J H,LEE S H,et al.Piglet gut microbial shifts early in life:causes and effects[J].Journal of Animal Science and Biotechnology,2019,10:1.
[17] GUEVARRA R B,HONG S H,CHO J H,et al.The dynamics of the piglet gut microbiome during the weaning transition in association with health and nutrition[J].Journal of Animal Science and Biotechnology,2018,9:54.
[18] YANAGIBASHI T,HOSONO A,OYAMA A,et al.IgA production in the large intestine is modulated by a different mechanism than in the small intestine:Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells[J].Immunobiology,2013,218(4):645-651.  
[19] 闫学艳.健康与腹泻仔猪肠道菌群差异研究及猪源乳酸杆菌的筛选[D].硕士学位论文.南昌:江西农业大学,2014.
[20] 汪群.腹泻与健康仔猪粪便菌群的比较及致病菌的分离与耐药性研究[D].硕士学位论文.广州:华南理工大学,2019.
[21] TRAN H,ANDERSON C L,BUNDY J W,et al.Effects of spray-dried porcine plasma on fecal microbiota in nursery pigs[J].Journal of Animal Sciences,2018,96(3):1017-1031.
[22] DUBOURG G,LAGIER J C,ARMOUGOM F,et al.High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment[J].International Journal of Antimicrobial Agents,2013,41(2):149-155.  
[23] NICOLAS G R,CHANG P V.Deciphering the chemical lexicon of host-gut microbiota interactions[J].Trends in Pharmacological Sciences,2019,40(6):430-445.  
[24] DOU S,GADONNA-WIDEHEM P,ROME V,et al.Characterisation of early-life fecal microbiota in susceptible and healthy pigs to post-weaning diarrhoea[J].PLoS One,2017,12(1):e0169851.
[25] 胡远亮.利用分子生物技术研究益生菌对断奶仔猪生长及粪便菌群的影响[D].博士学位论文.武汉:华中农业大学,2014.
[26] HU J,CHEN L L,ZHENG W Y,et al.Lactobacillus frumenti facilitates intestinal epithelial barrier function maintenance in early-weaned piglets[J].Frontiers in Microbiology,2018,9:897.
[27] LEE Y S,KIM T Y,KIM Y,et al.Microbiota-derived lactate accelerates intestinal stem-cell-mediated epithelial development[J].Cell Host & Microbe,2018,24(6):833-846.  
[28] PAN L,ZHAO P F,MA X K,et al.Probiotic supplementation protects weaned pigs against enterotoxigenic Escherichia coli K88 challenge and improves performance similar to antibiotics[J].Journal of Animal Science,2017,95(6):2627-2639.
[29] CHE L Q,XU Q,WU C,et al.Effects of dietary live yeast supplementation on growth performance,diarrhoea severity,intestinal permeability and immunological parameters of weaned piglets challenged with enterotoxigenic Escherichia coli K88[J].British Journal of Nutrition,2017,118(1):949-958.
[30] LI X Q,ZHU Y H,ZHANG H F,et al.Risks associated with high-dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea:intestinal microbiota and immune imbalances[J].PLoS One,2012,7(7):e40666.
[31] LIU Y L.Fatty acids,inflammation and intestinal health in pigs[J].Journal of Animal Science and Biotechnology,2015,6:41.
[32] CHEN J L,ZHENG P,ZHANG C,et al.Benzoic acid beneficially affects growth performance of weaned pigs which was associated with changes in gut bacterial populations,morphology indices and growth factor gene expression[J].Journal of Animal Physiology and Animal Nutrition,2017,101(6):1137-1146.  
[33] LI S,ZHENG J,DENG K,et al.Supplementation with organic acids showing different effects on growth performance,gut morphology,and microbiota of weaned pigs fed with highly or less digestible diets[J].Journal of Animal Science,2018,96(8):3302-3318.
[34] NAGALINGAM N A,KAO J Y,YOUNG V B.Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis[J].Inflammatory Bowel Diseases,2011,17(4):917-926.  
[35] BROWER-SINNING R,ZHONG D N,GOOD M,et al.Mucosa-associated bacterial diversity in necrotizing enterocolitis[J].PLoS One,2014,9(9):e105046.
[36] LAMENDELLA R,DOMINGO J W S,GHOSH S,et al.Comparative fecal metagenomics unveils unique functional capacity of the swine gut[J].BMC Microbiology,2011,11:103.
[37] SINGH N,GURAV A,SIVAPRAKASAM S,et al.Activation of GPR109A,receptor for niacin and the commensal metabolite butyrate,suppresses colonic inflammation and carcinogenesis[J].Immunity,2014,40(1):128-139.  
[38] CHANG P V,HAO L M,OFFERMANNS S,et al.The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(6):2247-2252.  
[39] ZOU X T,LU J J,WEN Z S.Effects of sodium butyrate on the intestinal morphology and DNA-binding activity of intestinal nuclear factor-κB in weanling pigs[J].Journal of Animal and Veterinary Advances,2012,11(6):814-821.  
[40] CAIRO P L G,GOIS F D,SBARDELLA M,et al.Effects of dietary supplementation of red pepper (Schinus terebinthifolius Raddi) essential oil on performance,small intestinal morphology and microbial counts of weanling pigs[J].Journal of the Science of Food & Agriculture,2018,98(2):541-548.  
[41] ZHAO J B,ZHANG G,ZHOU X J,et al.Effect of Dandelion root extract on growth performance,immune function and bacterial community in weaned pigs[J].Food and Agricultural Immunology,2019,30(1):95-111.  
[42] 杨玲,胡睿智,夏嗣廷,等.植物多糖的功能性研究进展及其在动物生产中的应用[J].动物营养学报,2019,31(6):2534-2543.
[43] XIE Z J,HU L S,LI Y,et al.Changes of gut microbiota structure and morphology in weaned piglets treated with fresh fermented soybean meal[J].World Journal of Microbiology and Biotechnology,2017,33(12):213.
[44] YUAN L,CHANG J,YIN Q Q,et al.Fermented soybean meal improves the growth performance,nutrient digestibility,and microbial flora in piglets[J].Animal Nutrition,2016,3(1):19-24.
[45] MACH N,BERRI M,ESTELLÉ J,et al.Early-life establishment of the swine gut microbiome and impact on host phenotypes[J].Environmental Microbiology Reports,2015,7(3):554-569.  
[46] YI H B,ZHANG L,GAN Z S,et al.High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine[J].Scientific Reports,2016,6:25679.
[47] HAN S J,YU H T,YANG F F,et al.Effect of dietary supplementation with hyperimmunized hen egg yolk powder on diarrhoea incidence and intestinal health of weaned pigs[J].Food and Agricultural Immunology,2019,30(1):333-348.  
[48] KIM M,QIE Y Q,PARK J,et al.Gut microbial metabolites fuel host antibody responses[J].Cell Host & Microbe,2016,20(2):202-214.  
[49] 李金龙.日粮色氨酸促进抗菌肽表达对肠道微生物区系的调控和ETEC的预防作用[D].硕士学位论文.重庆:西南大学,2018.
[50] PARK S K,KIM M S,BAE J W.Blautia faecis sp.nov.isolated from human faeces[J].International Journal of Systematic and Evolutionary Microbiology,2013,63(2):599-603.
[51] ZENG B,HAN S S,WANG P,et al.The bacterial communities associated with fecal types and body weight of rex rabbits[J].Scientific Reports,2015,5:9342.
[52] HAGLAND H R,SØREIDE K.Cellular metabolism in colorectal carcinogenesis:influence of lifestyle,gut microbiome and metabolic pathways[J].Cancer Letters,2015,356(2):273-280.  
[53] 陈雪,任二都,苏勇.早期灌喂母源粪菌对新生仔猪肠道菌群发育的影响[J].微生物学报,2018,58(7):1224-1232.
文章导航

/