[1] MCCALL K A,HUANG C C,FIERKE C A.Function and mechanism of zinc metalloenzymes[J].The Journal of Nutrition,2000,130(5):1437S-1446S.
[2] 陈良妹,董晓明,杨帆,等.锌缺乏症对慢性肾脏病发展的影响及其作用机制的研究进展[J].吉林大学学报(医学版),2018,44(1):195-199.
[3] TANEJA S K,JAIN M,MANDAL R,et al.Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level[J].Journal of Trace Elements in Medicine and Biology,2012,26(4):267-272.
[4] 罗治彬,吴嘉惠,徐采朴.过量锌对大鼠小肠粘膜SIgA免疫的影响[J].细胞与分子免疫学杂志,1998(4):295-296.
[5] 于昱,罗绪刚,吕林,等.动物小肠锌吸收特点及其机制的研究进展[J].肠外与肠内营养,2006,13(3):179-183,187.
[6] 高建伟,王林枫,杨改青,等.锌的消化吸收机制研究进展[J].安徽农业科学,2010,38(1):33-34,67.
[7] KREBS N F,HAMBIDGE K M,WESTCOTT J E,et al.Exchangeable zinc pool size in infants is related to key variables of zinc homeostasis[J].The Journal of Nutrition,2003,133(5):1498S-1501S.
[8] JOU M Y,PHILIPPS A F,KELLEHER S L,et al.Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity[J].Journal of Pediatric Gastroenterology and Nutrition,2010,50(6):587-595.
[9] GAITHER L A,EIDE D J.Functional expression of the human hZIP2 zinc transporter[J].Journal of Biological Chemistry,2000,275(8):5560-5564.
[10] HUANG L P,GITSCHIER J.A novel gene involved in zinc transport is deficient in the lethal milk mouse[J].Nature Genetics,1997,17(3):292-297.
[11] KAMBE T,YAMAGUCHI-IWAI Y,SASAKI R,et al.Overview of mammalian zinc transporters[J].Cellular and Molecular Life Sciences,2004,61(1):49-68.
[12] COUSINS R J,LIUZZI J P,LICHTEN L A.Mammalian zinc transport,trafficking,and signals[J].Journal of Biological Chemistry,2006,281(34):24085-24089.
[13] 于昱,王福俤.锌转运蛋白家族SLC39A/ZIP和SLC30A/ZnT的研究进展[J].中国细胞生物学学报,2010,32(2):176-188.
[14] KELLEHER S L,LOPEZ V,LÖNNERDAL B,et al.Zip3(Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland[J].American Journal of Physiology:Regulatory Integrative and Comparative Physiology,2009,297(1):R194-R201.
[15] LICHTEN L A,COUSINS R J.Mammalian zinc transporters:nutritional and physiologic regulation[J].Annual Review of Nutrition,2009,29:153-176.
[16] GEISER J,VENKEN K J T,DE LISLE R C,et al.A mouse model of acrodermatitis enteropathica:loss of intestine zinc transporter ZIP4(Slc39a4) disrupts the stem cell niche and intestine integrity[J].PLoS Genetics,2012,8(6):e1002766.
[17] DUFNER-BEATTIE J,KUO Y M,GITSCHIER J,et al.The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5[J].Journal of Biological Chemistry,2004,279(47):49082-49090.
[18] 乔珏,夏海滨.锌离子转运蛋白LIV-1的研究进展[J].现代肿瘤医学,2014,22(6):1454-1458.
[19] OLLIG J,KLOUBERT V,TAYLOR K M,et al.B cell activation and proliferation increase intracellular zinc levels[J].The Journal of Nutritional Biochemistry,2019,64:72-79.
[20] PALMITER R D.Protection against zinc toxicity by metallothionein and zinc transporter[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(14):4918-4923.
[21] YU Y Y,KIRSCHKE C P,HUANG L P.Immunohistochemical analysis of ZnT1,4,5,6,and 7 in the mouse gastrointestinal tract[J].Journal of Histochemistry & Cytochemistry,2007,55(3):223-234.
[22] YAMAJI S,TENNANT J,TANDY S,et al.Zinc regulates the function and expression of the iron transporters DMT1 and IREG1 in human intestinal Caco-2 cells[J].FEBS Letters,2001,507(2):137-141.
[23] YASUNO T,OKAMOTO H,NAGAI M,et al.
In vitro study on the transport of zinc across intestinal epithelial cells using Caco-2 monolayers and isolated rat intestinal membranes[J].Biological and Pharmaceutical Bulletin,2012,35(4):588-593.
[24] TAYLOR K M,NICHOLSON R I.The LZT proteins;the LIV-1 subfamily of zinc transporters[J].Biochimica et Biophysica Acta:Biomembranes,2003,1611(1/2):16-30.
[25] SHEN H,QIN H H,GUO J S.Cooperation of metallothionein and zinc transporters for regulating zinc homeostasis in human intestinal Caco-2 cells[J].Nutrition Research,2008,28(6):406-413.
[26] HOLLAND T C,KILLILEA D W,SHENVI S V,et al.Acute changes in cellular zinc alters zinc uptake rates prior to zinc transporter gene expression in Jurkat cells[J].BioMetals,2015,28(6):987-996.
[27] TAKO E,FERKET P R,UNI Z.Changes in chicken intestinal zinc exporter mRNA expression and small intestinal functionality following intra-amniotic zinc-methionine administration[J].The Journal of Nutritional Biochemistry,2005,16(6):339-346.
[28] LIU H W,LIU D S,ZHENG L X.Study on Zn relative concentration and chemical state in broilers duodenum by micro-X-ray fluorescence and micro-X-ray absorption fine structure[J].Livestock Science,2014,161:101-108.
[29] ZHOU J Y,LIN H L,WANG Z,et al.Zinc
L-Aspartate enhances intestinal stem cell activity to protect the integrity of the intestinal mucosa against deoxynivalenol through activation of the Wnt/β-catenin signaling pathway[J].Environmental Pollution,2020,262:114290.
[30] YUE M,FANG S L,ZHUO Z,et al.Zinc glycine chelate absorption characteristics in sprague dawley rat[J].Journal of Animal Physiology and Animal Nutrition,2015,99(3):457-464.
[31] HUANG D P,ZHUO Z,FANG S L,et al.Different zinc sources have diverse impacts on gene expression of zinc absorption related transporters in intestinal porcine epithelial cells[J].Biological Trace Element Research,2016,173(2):325-332.
[32] YEUNG T M,CHIA L A,KOSINSKI C M,et al.Regulation of self-renewal and differentiation by the intestinal stem cell niche[J].Cellular and Molecular Life Sciences,2011,68(15):2513-2523.
[33] AMCHESLAVSKY A,NIE Y C,LI Q,et al.Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila[J].Development,2014,141(13):2621-2632.
[34] OHASHI W,KIMURA S,IWANAGA T,et al.Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress[J].PLoS Genetics,2016,12(10):e1006349.
[35] BLANCHARD R K,COUSINS R J.Differential display of intestinal mRNAs regulated by dietary zinc[J].Proceedings of the National Academy of Sciences of the United States of America,1996,93(14):6863-6868.
[36] DUFF M,ETTARH R R.Crypt cell production rate in the small intestine of the zinc-supplemented mouse[J].Cells Tissues Organs,2002,172(1):21-28.
[37] 郑立鑫,刘华伟,吴鹏华,等.不同锌源对肉仔鸡肠道形态及金属硫蛋白表达的影响[J].中国饲料,2013(20):7-10.
[38] ZHANG B K,GUO Y M.Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1(
ZO-1) expression in weaning piglets[J].British Journal of Nutrition,2009,102(5):687-693.
[39] SHAO Y X,WOLF P G,GUO S S,et al.Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells[J].The Journal of Nutritional Biochemistry,2017,43:18-26.
[40] 金美林,岳小婧,莫才红,等.日粮添加黄芪和锌对肉鸡生产性能、肠道微生物及抗氧化能力的影响[J].中兽医医药杂志,2017,36(4):55-58.
[41] CARIO E,JUNG S,D'HEUREUSE J H,et al.Effects of exogenous zinc supplementation on intestinal epithelial repair
in vitro[J].European Journal of Clinical Investigation,2000,30(5):419-428.
[42] HAN X Y,MA Y F,LV M Y,et al.Chitosan-zinc chelate improves intestinal structure and mucosal function and decreases apoptosis in ileal mucosal epithelial cells in weaned pigs[J].British Journal of Nutrition,2014,111(8):1405-1411.
[43] HOLODOVA M,COBANOVA K,SEFCIKOVA Z,et al.Dietary zinc and fibre source can influence the mineral and antioxidant status of piglets[J].Animals,2019,9(8):497.
[44] TRAN C D,HAWKES J,GRAHAM R D,et al.Zinc-fortified oral rehydration solution improved intestinal permeability and small intestinal mucosal recovery[J].Clinical Pediatrics,2015,54(7):676-682.
[45] MAHMOOD A,FITZGERALD A J,MARCHBANK T,et al.Zinc carnosine,a health food supplement that stabilises small bowel integrity and stimulates gut repair processes[J].Gut,2007,56(2):168-175.
[46] TRAN C D,HOWARTH G S,COYLE P,et al.Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine[J].The American Journal of Clinical Nutrition,2003,77(5):1296-1303.
[47] ZHANG B K,GUO Y M.Beneficial effects of tetrabasic zinc chloride for weanling piglets and the bioavailability of zinc in tetrabasic form relative to ZnO[J].Animal Feed Science and Technology,2007,135(1/2):75-85.
[48] POULSEN H D.Zinc oxide for weanling piglets[J].Acta Agriculturae Scandinavica,SectionA:Animal Sciences,1995,45(3):159-167.
[49] CARLSON D,POULSEN H D,SEHESTED J.Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose,theophylline and 5-HT in piglet small intestinal mucosa[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2004,137(4):757-765.
[50] CARLSON D,SEHESTED J,FENG Z,et al.Serosal zinc attenuate serotonin and vasoactive intestinal peptide induced secretion in piglet small intestinal epithelium
in vitro[J].Comparative Biochemistry and Physiology Part A:Molecular & Integrative Physiology,2008,149(1):51-58.
[51] OU D Y,LI D F,CAO Y H,et al.Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs[J].The Journal of Nutritional Biochemistry,2007,18(12):820-826.
[52] 张崇远.葡萄糖酸锌治疗儿童腹泻作用机制研究进展[J].中国处方药,2017,15(10):18-19.
[53] ZHU M,WANG X Q.Regulation of mTORC1 by small GTPases in response to nutrients[J].The Journal of Nutrition,2020,150(5):1004-1011,doi:10.1093/jn/nxz301.
[54] 朱秋杰,周加义,梁少杰,等.Wnt/β-连环蛋白信号驱动小肠上皮更新和再生机制的研究进展[J].动物营养学报,2019,31(11):4995-5002.
[55] ZHOU J Y,WANG Z,ZHANG S W,et al.Methionine and its hydroxyl analogues improve stem cell activity to eliminate deoxynivalenol-induced intestinal injury by reactivating Wnt/β-catenin signaling[J].Journal of Agricultural and Food Chemistry,2019,67(41):11464-11473.
[56] LI X G,ZHU M,CHEN M X,et al.Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway[J].Toxicology Letters,2019,305:19-31.
[57] ZHOU J Y,ZHANG S W,LIN H L,et al.Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice[J].Food and Chemical Toxicology,2019,131:110579.
[58] ZHU M,QIN Y C,GAO C Q,et al.
L-glutamate drives porcine intestinal epithelial renewal by increasing stem cell activity via upregulation of the EGFR-ERK-mTORC1 pathway[J].Food & Function,2020,11(3):2714-2724.
[59] ZHU M,QIN Y C,GAO C Q,et al.Extracellular glutamate-induced mTORC1 activation via the IR/IRS/PI3K/Akt pathway enhances the expansion of porcine intestinal stem cells[J].Journal of Agricultural and Food Chemistry,2019,67(34):9510-9521.
[60] ZHOU J Y,HUANG D G,QIN Y C,et al.mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation[J].Journal of Cellular Physiology,2019,234(10):19028-19038.
[61] STRUBBERG A M,PANIAGUA D A V,ZHAO T T,et al.The zinc finger transcription factor PLAGL2 enhances stem cell fate and activates expression of ASCL2 in intestinal epithelial cells[J].Stem Cell Reports,2018,11(2):410-424.
[62] LI X G,WANG Z,CHEN R Q,et al.Lgr5 and Bmi1 increase pig intestinal epithelial cell proliferation by stimulating Wnt/β-catenin signaling[J].International Journal of Molecular Sciences,2018,19(4):1036-1048.
[63] MACDONALD B T,TAMAI K,HE X.Wnt/β-catenin signaling:components,mechanisms,and diseases[J].Developmental Cell,2009,17(1):9-26.
[64] NIMMANON T,ZILIOTTO S,MORRIS S,et al.Phosphorylation of zinc channel ZIP7 drives MAPK,PI3K and mTOR growth and proliferation signalling[J].Metallomics,2017,9(5):471-481.
[65] LYNCH C J,PATSON B J,GOODMAN S A,et al.Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR[J].American Journal of Physiology:Endocrinology and Metabolism,2001,281(1):E25-E34.
京公网安备 11010802041926号