[1] 张志琴.松属植物化学成分研究进展[J].中国药业,2015,24(5):94-96. ZHANG Z Q.Research progress on chemical constituents of
Pinus plants[J].China Pharmaceuticals,2015,24(5):94-96.(in Chinese)
[2] 石晓峰,沈薇,宁红霞,等.雪松松针总多酚的纯化工艺和抗氧化活性研究[J].天然产物研究与开发,2016,28(8):1325-1331. SHI X F,SHEN W,NING H X,et al.Purification and antioxidant activity of polyphenol[J].Natural Product Research and Development,2016,28(8):1325-1331.(in Chinese)
[3] 王群.几种松科植物活性成分及多酚抗氧化性能力的研究[D].硕士学位论文.哈尔滨:东北林业大学,2016. WANG Q.Research on the active ingredients and antioxidant activity of polyphenols from several kinds of pinaceae plants[D].Master's Thesis.Harbin:Northeast Forestry University,2016.(in Chinese)
[4] BAYOMY N A,ABDELAZIZ E Z,SAID M A,et al.Effect of pycnogenol and spirulina on vancomycin-induced renal cortical oxidative stress,apoptosis,and autophagy in adult male albino rat[J].Canadian Journal of Physiology and Pharmacology,2016,94(8):838-848.

[5] PACKER L,RIMBACH G,VIRGILI F.Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (
Pinus maritima) bark,pycnogenol[J].Free Radical Biology Medicine,1999,27(5/6):704-724.
[6] 黄占华.落叶松单宁及其水处理剂制备技术[M].北京:化学工业出版社,2008. HUANG Z H.Larch tannin and its water treatment agent preparation technology[M].Beijing:Chemical Industry Press,2008.(in Chinese)
[7] LIS A,KALINOWSKA A,KRAJEWSKA A,et al.Chemical composition of the essential oils from different morphological parts of
Pinus cembra L.[J].Chemistry & Biodiversity,2017,14(4):e1600345.
[8] ÖZGENÇ Ö,DURMAZ S,ÇELIK G,et al.Comparative phytochemical analysis of volatile organic compounds by SPME-GC-FID/MS from six coniferous and nine deciduous tree bark species grown in Turkey[J].South African Journal of Botany,2017,113:23-28.
[9] LABIB R M,YOUSSEF F S,ASHOUR M L,et al.Chemical composition of
Pinus roxburghii bark volatile oil and validation of its anti-inflammatory activity using molecular modelling and bleomycin-induced inflammation in
Albino mice[J].Molecules,2017,22(9):1384.
[10] HALUB B,SHAKYA A K,ELAGBAR Z A,et al.GC-MS analysis and biological activity of essential oil of fruits,needles and bark of
Pinus pinea grown wildly in Jordan[J].Acta Poloniae Pharmaceutica (Drug Research),2019,76(5):825-831.

[11] SATYAL P,PAUDEL P,RAUT J,et al.Volatile constituents of
Pinus roxburghii from Nepal[J].Pharmacognosy Research,2013,5(1):43-48.

[12] APETREI C L,TUCHILUS C,APROTOSOAIE A C,et al.Chemical,antioxidant and antimicrobial investigations of
Pinus cembra L. bark and needles[J].Molecules,2011,16(9):7773-7788.

[13] CRETU E,KARONEN M,SALMINEN J P,et al.
In vitro study on the antioxidant activity of a polyphenol-rich extract from
Pinus brutia bark and its fractions[J].Journal of Medicinal Food,2013,16(11):984-991.

[14] ROSALES-CASTRO M,GONZÁLEZ-LAREDO R F,RIVAS-ARREOLA M J,et al.Chemical analysis of polyphenols with antioxidant capacity from
Pinus durangensis bark[J].Journal of Wood Chemistry and Technology,2017,37(5):393-404.

[15] KU C S,JANG J P,MUN S P.Exploitation of polyphenol-rich pine barks for potent antioxidant activity[J].Journal of Wood Science,2007,53(6):524-528.

[16] DE LA LUZ CÁDIZ-GURREA M,FERNÁNDEZ-ARROYO S,SEGURA-CARRETERO A.Pine bark and green tea concentrated extracts:antioxidant activity and comprehensive characterization of bioactive compounds by HPLC-ESI-QTOF-MS[J].International Journal of Molecular Sciences,2014,15(11):20382-20402.

[17] KU C S,MUN S P.Antioxidant properties of monomeric,oligomeric,and polymeric fractions in hot water extract from
Pinus radiata bark[J].Wood Science and Technology,2008,42(1):47-60.

[18] KIM J W,IM S,JEONG H R,et al.Neuroprotective effects of Korean red pine (
Pinus densiflora) bark extract and its phenolics[J].Journal of Microbiology and Biotechnology,2018,28(5):679-687.

[19] DRÓŻDŻ P,PYRZYNSKA K.Extracts from pine and oak barks:phenolics,minerals and antioxidant potential[J].International Journal of Environmental Analytical Chemistry,2019,doi:10.1080/03067319.2019.1668381.
[20] YESIL-CELIKTAS O,OTTO F,PARLAR H.A comparative study of flavonoid contents and antioxidant activities of supercritical CO
2 extracted pine barks grown in different regions of Turkey and Germany[J].European Food Research and Technology,2009,229(4):671-677.

[21] KARONEN M,LOPONEN J,OSSIPOV V,et al.Analysis of procyanidins in pine bark with reversed-phase and normal-phase high-performance liquid chromatography-electrospray ionization mass spectrometry[J].Analytica Chimica Acta,2004,522(1):105-112.

[22] 洪瑜,黄云生,甄珍,等.松树皮中提取原花青素的研究进展[J].中国林副特产,2016(2):97-98. HONG Y,HUANG Y S,ZHEN Z,et al.The research progress of procyanidins of pine bark[J].Product and Speciality in China,2016(2):97-98.(in Chinese)
[23] 李波,包怡红,王振宇.松多酚生物活性研究进展[J].黑龙江农业科学,2013(10):133-136. LI B,BAO Y H,WANG Z Y.Research progress on biological activity of pine polyphenols[J].Heilongjiang Agricultural Sciences,2013(10):133-136.(in Chinese)
[24] ROHDEWALD P J.Review on sustained relief of osteoarthritis symptoms with a proprietary extract from pine bark,pycnogenol[J].Journal of Medicinal Food,2018,21(1):1-4.

[25] 伍树松,李柏珍,刘明,等.一种从松树皮中提取酚类物质的方法:CN,110538204A[P].2019-12-06. WU S S,LI B Z,LIU M,et al.A method for extracting phenolic substances from pine bark:CN,110538204A[P].2019-12-06.(in Chinese)
[26] 马聪.湿地松树皮活性成分制备工艺及产物特性研究[D].硕士学位论文.长沙:中南大学,2007. MA C.Study on the preparation technology and product characteristics of active ingredients from slash pine bark[D].Master's Thesis.Changsha:Central South University,2007.(in Chinese)
[27] LI Y Y,FENG J,ZHANG X L,et al.Pine bark extracts:nutraceutical,pharmacological,and toxicological evaluation[J].Journal of Pharmacology and Experimental Therapeutics,2015,353(1):9-16.

[28] WANG X Y,WANG S S,HUANG S S,et al.Purification of polyphenols from distiller's grains by macroporous resin and analysis of the polyphenolic components[J].Molecules,2019,24(7):1284.
[29] PAN H F,LUNDGREN L N.Phenolics from inner bark of
Pinus sylvestris[J].Phytochemistry,1996,42(4):1185-1189.

[30] JEREZ M,SINEIRO J,GUITIÁN E,et al.Identification of polymeric procyanidins from pine bark by mass spectrometry[J].Rapid Communications in Mass Spectrometry,2009,23(24):4013-4018.

[31] 吴杰,关阳,刘跃芹,等.不同品种松树皮活性成分及其提取影响因素[J].广州化工,2013,41(16):68-71. WU J,GUAN Y,LIU Y Q,et al.The content of active components of different varieties of pine bark and extraction factors[J].Guangzhou Chemical Industry,2013,41(16):68-71.(in Chinese)
[32] 何美军,杨斌,郑莉,等.云南东川华山松健康树皮中矿质元素的测定[J].山东林业科技,2006(5):8-10. HE M J,YANG B,ZHENG L,et al.Determination of mineral elements in the healthy bark of
Pinus armandii from dongchuang in
Yunnan province[J].Shandong Forestry Science and Technology,2006(5):8-10.(in Chinese)
[33] 韩松,张文治.松属植物的化学成分及生物活性研究进展[J].高师理科学刊,2018,38(7):47-50. HAN S,ZHANG W Z.Research progress on chemical component and biological activity of Pinus[J].Journal of Science of Teachers'College and University,2018,38(7):47-50.(in Chinese)
[34] ZHAO T T,SHEN X J,DAI C,et al.Benefits of procyanidins on gut microbiota in Bama minipigs and implications in replacing antibiotics[J].Journal of Veterinary Science,2018,19(6):798-807.

[35] EL-GHORAB A H,EL-MASSRY K F,SHAABAN H A.Effect of drying on the chemical composition of the egyptian
Cupressus macrocarpa (Hartw.ex gordon) essential oils and their biological characteristics[J].Journal of Essential Oil Bearing Plants,2007,10(5):399-411.

[36] HAMAD A M A,ATES S,OLGUN Ç,et al.Chemical composition and antioxidant properties of some industrial tree bark extracts[J].BioResources,2019,14(3):5657-5671.
[37] SHARMA A,GOYAL R,SHARMA L.Potential biological efficacy of Pinus plant species against oxidative,inflammatory and microbial disorders[J].BMC Complementary and Alternative Medicine,2015,16:35.
[38] 刘志芹.不同植物材料总多酚的测定及抑菌特性研究[D].硕士学位论文.北京:北京林业大学,2004. LIU Z Q.Measuration and anti-fungal study of polyphenols in different plant materials[D].Master's Thesis.Beijing:Beijing Forestry University,2004.(in Chinese)
[39] VALENCIA-AVILÉS E,MARTÍNEZ-FLORES H E,GARCÍA-PÉREZ M,et al.Investigation of the antibacterial activity and subacute toxicity of a
Quercus crassifolia polyphenolic bark extract for its potential use in functional foods[J].Journal of Food Science,2019,84(7):1692-1702.

[40] SUGIMOTO H,WATANABE K,TOYAMA T,et al.Inhibitory effects of French pine bark extract,Pycnogenol,on alveolar bone resorption and on the osteoclast differentiation[J].Phytotherapy Research,2015,29(2):251-259.

[41] FENG J,ZHANG X L,LI Y Y,et al.
Pinus massoniana bark extract:structure-activity relationship and biomedical potentials[J].The American Journal of Chinese Medicine,2016,44(8):1559-1577.

[42] TORRAS M A C,FAURA C A,SCHÖNLAU F,et al.Antimicrobial activity of pycnogenol[J].Phytotherapy Research,2005,19(7):647-648.

[43] BERNARD F X,SABLÉ S,CAMERON B,et al.Glycosylated flavones as selective inhibitors of topoisomerase Ⅳ[J].Antimicrobial Agents and Chemotherapy,1997,41(5):992-998.

[44] 刘明,伍树松,方洛云,等.原花青素在畜禽生产中的研究与应用[J].动物营养学报,2018,30(8):2902-2910. LIU M,WU S S,FANG L Y,et al.Research and application of proanthocyanidins in livestock production[J].Chinese Journal of Animal Nutrition,2018,30(8):2902-2910.(in Chinese)
[45] 胡睿智,贺宇佳,李柏珍,等.原儿茶酸的生理功能及其在畜禽生产中的应用[J].动物营养学报,2019,31(11):4978-4985. HU R Z,HE Y J,LI B Z,et al.Biological functions of protocatechuic acid and its application in livestock and poultry production[J].Chinese Journal of Animal Nutrition,2019,31(11):4978-4985.(in Chinese)
[46] QIN S,DENG F M,WU W G,et al.Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms[J].Archives of Biochemistry and Biophysics,2014,559:53-61.
[47] NAKAYAMA S,KISHIMOTO Y,SAITA E,et al.Pine bark extract prevents low-density lipoprotein oxidation and regulates monocytic expression of antioxidant enzymes[J].Nutrition Research,2015,35(1):56-64.

[48] KO J W,LEE I C,PARK S H,et al.Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats[J].Laboratory Animal Research,2014,30(4):174-180.

[49] DAI F,CHEN W F,ZHOU B.Antioxidant synergism of green tea polyphenols with α-tocopherol and l-ascorbic acid in SDS micelles[J].Biochimie,2008,90(10):1499-1505.

[50] VIGO E,CEPEDA A,GUALILLO O,et al.
In-
vitro anti-inflammatory activity of
Pinus sylvestris and
Plantago lanceolata extracts:effect on inducible NOS,COX-1,COX-2 and their products in J774A.1 murine macrophages[J].Journal of Pharmacy and Pharmacology,2005,57(3):383-391.

[51] QIN S,DENG F M,WU W G,et al.Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms[J].Archives of Biochemistry and Biophysics,2014,559:53-61.
[52] 陆峰彬,王瑞,陈露,等.松树皮提取物对鱼藤酮诱导帕金森小鼠神经元的保护作用[J].现代预防医学,2014,41(8):1468-1471. LU F B,WANG R,CHEN L,et al. Protective effect of pine bark extract on impaired neuron in rotenone induced Parkinson's disease mouse model[J].Modern Preventive Medicine,2014,41(8):1468-1471.(in Chinese)
[53] 王俊,任美萍,胡博,等.松树皮原花青素提取物对糖尿病小鼠的血糖的影响[J].食品研究与开发,2017,38(7):164-167. WANG J,REN M P,HU B,et al.Effects of pine bark procyanidins extract on blood glucose in diabetic mice[J].Food Research And Development,2017,38(7):164-167.(in Chinese)
[54] 刘重斌,王瑞,陆峰彬,等.松树皮提取物对帕金森模型小鼠行为损伤及氧化应激的作用[J].营养学报,2013,35(6):587-593. LIU C B,WANG R,LU F B,et al.Effect of pine bark extract on behavioral impairments and oxidative[J].Acta Nutrimenta Sinica,2013,35(6):587-593.(in Chinese)
[55] KIM K J,HWANG E S,KIM M J,et al.Antihypertensive effects of polyphenolic extract from Korean red pine (
Pinus densiflora Sieb. et Zucc.) bark in spontaneously hypertensive rats[J].Antioxidants,2020,9(4):333.
[56] KIM Y J,KANG K S,YOKOZAWA T.The anti-melanogenic effect of pycnogenol by its anti-oxidative actions[J].Food and Chemical Toxicology,2008,46(7):2466-2471.

[57] CHO K J,YUN C H,YOON D Y,et al.Effect of bioflavonoids extracted from the bark of
Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7[J].Toxicology and Applied Pharmacology,2000,168(1):64-71.

[58] MÁRMOL I,QUERO J,JIMÉNEZ-MORENO N,et al.A systematic review of the potential uses of pine bark in food industry and health care[J].Trends in Food Science & Technology,2019,88:558-566.
[59] 陈世伟,刘翠娥,张杰,等.碧萝芷对肿瘤生长和非特异性免疫作用的影响[J].河南预防医学杂志,2003,14(1):16-18. CHEN S W,LIU C E,ZHANG J,et al.Effect of pycoogenol in tumour and non-specific immune system[J].Henan Journal of Preventive Medicine,2003,14(1):16-18.(in Chinese)
[60] LEE J,NAM D E,KIM O K,et al.Pycnogenol attenuates the symptoms of immune dysfunction through restoring a cellular antioxidant status in low micronutrient-induced immune deficient mice[J].Nutrition Research and Practice,2014,8(5):533-538.

[61] PARK I J,CHA S Y,KANG M,et al.Effect of proanthocyanidin-rich extract from
Pinus radiata bark on immune response of specific-pathogen-free white Leghorn chickens[J].Poultry Science,2011,90(5):977-982.

[62] 贺宇佳,刘明,伍树松.植物多酚对氧化应激与炎症信号通路的调控机制[J].动物营养学报,2019,31(4):1554-1563. HE Y J,LIU M,WU S S.Regulation mechanism of plant polyphenols in oxidative stress and inflammatory signaling pathways[J].Chinese Journal of Animal Nutrition,2019,31(4):1554-1563.(in Chinese)
[63] 崔莲花,辛宗瑞,严昌国.松树皮提取物对育肥猪生长性能、血液指标及胴体性能的影响[J].黑龙江畜牧兽医,2012(12):57-59. CUI L H,XIN Z R,YAN C G.Effect of pine bark extract on growth performance, blood index and carcass performance of finishing pigs[J].Heilongjiang Animal Science and Veterinary Medicine,2012(12):57-59.(in Chinese)
[64] SIERŻANT K,ORDA J,KORZENIOWSKA M,et al.Effect of dietary supplementation with extracts of rosemary,olive leaves,pine bark and quercetin on selected performance indices of broiler chickens and microbiological status of their ileum[J].Medycyna Weterynaryjna,2019,75(4):247-252.
[65] YANG H,CHOWDHURY V S,BAHRY M A,et al.Chronic oral administration of pine bark extract (flavangenol) attenuates brain and liver mRNA expressions of HSPs in heat-exposed chicks[J].Journal of Thermal Biology,2016,60:140-148.
[66] WU Q J,WANG Y Q,QI Y X.Influence of procyanidin supplementation on the immune responses of broilers challenged with lipopolysaccharide[J].Animal Science Journal,2017,88(7):983-990.