[1] THEILER A,GREEN H H,VILJOEN P R.Contribution to the study of deficiency disease, with special reference to the lamziekte problem in South Africa[J].Chemical Abstracts,1915,11:164-168.
[2] ZINN R A,OWENS F N,STUART R L,et al.B-vitamin supplementation of diets for feedlot calves[J].Journal of Animal Science,1987,65(1):267-277.

[3] WANG H R,PAN X H,WANG C,et al.Effects of different dietary concentrate to forage ratio and thiamine supplementation on the rumen fermentation and ruminal bacterial community in dairy cows[J].Animal Production Science,2014,55(2):189-193.
[4] DU H S,WANG C,WU Z Z,et al.Effects of rumen-protected folic acid and rumen-protected sodium selenite supplementation on lactation performance,nutrient digestion,ruminal fermentation and blood metabolites in dairy cows[J].Journal of the Science of Food and Agriculture,2019,99(13):5826-5833.

[5] HAUSMANN J,DEINER C,PATRA A K,et al.Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition,energy metabolism and milk performance in transition dairy cows[J].PLOS One,2018,13(3):e0193685.
[6] 王雪莹,王之盛,薛白,等.烟酸对热应激牦牛生长性能、营养物质表观消化率和血液指标的影响[J].动物营养学报,2020,32(5):2228-2240. WANG X Y,WANG Z C,XUE B,et al.Effects of niacin on growth performance,nutrient apparent digestibility and blood indexes of yak under heat-stress[J].Chinese Journal of Animal Nutrition,2020,32(5):2228-2240.(in Chinese)
[7] JUCHEM S O,ROBINSON P H,EVANS E.A fat based rumen protection technology post-ruminally delivers a B vitamin complex to impact performance of multiparous Holstein cows[J].Animal Feed Science and Technology,2012,174(1-2):68-78.

[8] PAN X H,XUE F G,NAN X M,et al.Illumina sequencing approach to characterize thiamine metabolism related bacteria and the impacts of thiamine supplementation on ruminal microbiota in dairy cows fed high-grain diets[J].Frontiers in Microbiology,2017,8:1818.
[9] PAN X H,YANG L,BECKERS Y,et al.Thiamine supplementation facilitates thiamine transporter expression in the rumen epithelium and attenuates high-grain-induced inflammation in low-yielding dairy cows[J].Journal of Dairy Science,2017,100(7):5329-5342.

[10] PAN X H,NAN X M,YANG L,et al.Thiamine status,metabolism and application in dairy cows:a review[J].The British Journal of Nutrition,2018,120(5):491-499.

[11] ASCHENBACH J R,ZEBELI Q,PATRA A K,et al.Symposium review:the importance of the ruminal epithelial barrier for a healthy and productive cow[J].Journal of Dairy Science,2019,102(2):1866-1882.

[12] BEAUCHESNE E,DESJARDINS P,HAZELL A S,et al.Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain[J].Neurochemistry International,2009,55(5):275-281.

[13] RIVERON-NEGRETE L,FERNANDEZ-MEJIA C.Pharmacological effects of biotin in animals[J].Mini Reviews in Medicinal Chemistry,2017,17(6):529-540.

[14] BAMPIDIS V A,LYMBEROPOULOS A G,CHRISTODOULOU V,et al.Impacts of supplemental dietary biotin on lameness in sheep[J].Animal Feed Science and Technology,2007,134(1-2):162-169.

[15] COLLIS V J,GREEN L E,BLOWEY R W,et al.Testing white line strength in the dairy cow[J].Journal of Dairy Science,2004,87(9):2874-2880.

[16] BERGSTEN C,GREENOUGH P R,GAY J M,et al.Effects of biotin supplementation on performance and claw lesions on a commercial dairy farm[J].Journal of Dairy Science,2003,86(12):3953-3962.

[17] WRINKLE S R,ROBINSON P H,GARRETT J E.Niacin delivery to the intestinal absorptive site impacts heat stress and productivity responses of high producing dairy cows during hot conditions[J].Animal Feed Science and Technology,2012,175(1-2):33-47.

[18] SACADURA F C,ROBINSON P H,EVANS E,et al.Effects of a ruminally protected B-vitamin supplement on milk yield and composition of lactating dairy cows[J].Animal Feed Science and Technology,2008,144(1-2):111-124.

[19] MOREY S D,MAMEDOVA L K,ANDERSON D E,et al.Effects of encapsulated niacin on metabolism and production of periparturient dairy cows[J].Journal of Dairy Science,2011,94(10):5090-5104.

[20] MORRISON E I,REINHARDT H,LECLERC H,et al.Effect of rumen-protected B vitamins and choline supplementation on health,production,and reproduction in transition dairy cows[J].Journal of Dairy Science,2018,101(10):9016-9027.

[21] WANG D M,ZHANG B X,WANG J K,et al.Short communication:effects of dietary 5,6-dimethylbenzimidazole supplementation on vitamin B
12 supply,lactation performance,and energy balance in dairy cows during the transition period and early lactation[J].Journal of Dairy Science,2018,101(3):2144-2147.

[22] KEADY T W,HANRAHAN J P,FAGAN S P.Cobalt supplementation,alone or in combination with vitamin B and selenium:effects on lamb performance and mineral status[J].Journal of Animal Science,2017,95(1):379-386.
[23] LI H Q,WANG B,LI Z,et al.Effects of rumen-protected folic acid addition in maternal and post-weaning diets on growth performance,total tract digestibility,ruminal fermentation and blood metabolites in lambs[J].Animal Feed Science and Technology,2020,260:114364.
[24] LA S K,LI H,WANG C,et al.Effects of rumen-protected folic acid and dietary protein level on growth performance,ruminal fermentation,nutrient digestibility and hepatic gene expression of dairy calves[J].Journal of Animal Physiology and Animal Nutrition,2019,103(4):1006-1014.
[25] WANG C,LIU Q,GUO G,et al.Effects of rumen-protected folic acid and branched-chain volatile fatty acids supplementation on lactation performance,ruminal fermentation,nutrient digestion and blood metabolites in dairy cows[J].Animal Feed Science and Technology,2019,247:157-165.
[26] YANG Z Q,BAO L B,ZHAO X H,et al.Nicotinic acid supplementation in diet favored intramuscular fat deposition and lipid metabolism in finishing steers[J].Experimental Biology and Medicine,2016,241(11):1195-1201.

[27] CHRISTODOULOU V,BAMPIDIS V A,LYMBEROPOULOS A G,et al.Effect of supplemental dietary biotin on performance of lactating ewes[J].Animal Feed Science and Technology,2006,130(3-4):268-276.

[28] MAJEE D N,SCHWAB E C,BERTICS S J,et al.Lactation performance by dairy cows fed supplemental biotin and a B-vitamin blend[J].Journal of Dairy Science,2003,86(6):2106-2112.

[29] WANG J X,CAO Y,FU S P,et al.Niacin inhibits the synthesis of milk fat in BMECs through the GPR109A-mediated downstream signalling pathway[J].Life Sciences,2020,260:118415.
[30] PIRES J A A,STUMPF L F,SOUTULLO I D,et al.Effects of abomasal infusion of nicotinic acid on responses to glucose and β-agonist challenges in underfed lactating cows[J].Journal of Dairy Science,2016,99(3):2297-2307.

[31] STAPLES C R,THATCHER W W,CLARK J H.Relationship between ovarian activity and energy status during the early postpartum period of high producing dairy cows[J].Journal of Dairy Science,1990,73(4):938-947.

[32] KANAKKAPARAMBIL R,SINGH R,LI D,et al.B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep[J].Biology of Reproduction,2009,80(4):743-752.

[33] KAUR M,HARTLING I,BURNETT T A,et al.Rumen-protected B vitamin complex supplementation during the transition period and early lactation alters endometrium mRNA expression on day 14 of gestation in lactating dairy cows[J].Journal of Dairy Science,2019,102(2):1642-1657.

[34] DUPLESSIS M,GIRARD C L,SANTSCHI D E,et al.Effects of folic acid and vitamin B
12 supplementation on culling rate,diseases,and reproduction in commercial dairy herds[J].Journal of Dairy Science,2014,97(4):2346-2354.

[35] MATHIS D,SHOELSON S E.Immunometabolism:an emerging frontier[J].Nature Reviews Immunology,2011,11(2):81.
[36] BUCK M D,SOWELL R T,KAECH S M,et al.Metabolic instruction of immunity[J].Cell,2017,169(4):570-586.

[37] WEI X S,ZHAO H H,HE J J,et al.Maternal nicotinamide supplementation during the perinatal period modifies the small intestine morphology and antioxidative status of offspring kids[J].Animal Feed Science and Technology,2019,252:41-50.
[38] ARAGONA K M,CHAPMAN C E,PEREIRA A B D,et al.Prepartum supplementation of nicotinic acid:effects on health of the dam,colostrum quality,and acquisition of immunity in the calf[J].Journal of Dairy Science,2016,99(5):3529-3538.

[39] CHAI J T,DIGBY J E,CHOUDHURY R P.GPR109A and vascular inflammation[J].Current Atherosclerosis Reports,2013,15(5):325.
[40] GIRI B,BELANGER K,SEAMON M,et al.Niacin ameliorates neuro-inflammation in parkinson's disease via GPR109A[J].International Journal of Molecular Sciences,2019,20(18):4559.
[41] LIPSZYC P S,CREMASCHI G A,ZORRILLA-ZUBILETE M,et al.Niacin modulates pro-inflammatory cytokine secretion.A potential mechanism involved in its anti-atherosclerotic effect[J].The Open Cardiovascular Medicine Journal,2013,7:90-98.
[42] INGVARTSEN K L,MOYES K M.Factors contributing to immunosuppression in the dairy cow during the periparturient period[J].The Japanese Journal of Veterinary Research,2015,63(Suppl.1):S15-S24.
[43] 蒋亚军.烟酸、核黄素对奶牛生产性能、抗氧化能力和免疫力的影响[D].硕士学位论文.石河子:石河子大学,2011. JIANG Y J.Effects of nicotinic acidriboflavin on performance,antioxidant capacitiy and immunity of dairy cows[D].Master's Thesis.Shihezi:Shihezi University,2011.(in Chinese)
[44] DUBESKI P L,D'OFFAY J M,OWENS F N,et al.Effects of B vitamin injection on bovine herpesvirus-1 infection and immunity in feed-restricted beef calves[J].Journal of Animal Science,1996,74(6):1367-1374.

[45] BEAUDET V,GERVAIS R,GRAULET B,et al.Effects of dietary nitrogen levels and carbohydrate sources on apparent ruminal synthesis of some B vitamins in dairy cows[J].Jounal of Dairy Science,2016,99(4):2730-2739.

[46] SECK M,LINTON J A V,ALLEN M S,et al.Apparent ruminal synthesis of B vitamins in lactating dairy cows fed diets with different forage-to-concentrate ratios[J].Journal of Dairy Science,2017,100(3):1914-1922.

[47] CASTAGNINO D S,KAMMES K L,ALLEN M S,et al.Particle length of silages affects apparent ruminal synthesis of B vitamins in lactating dairy cows[J].Journal of Dairy Science,2016,99(8):6229-6236.

[48] CASTAGNINO D S,SECK M,BEAUDET V,et al.Effects of forage family on apparent ruminal synthesis of B vitamins in lactating dairy cows[J].Journal of Dairy Science,2016,99(3):1884-1894.

[49] SCHWAB E C,SCHWAB C G,SHAVER R D,et al.Dietary forage and nonfiber carbohydrate contents influence B-vitamin intake,duodenal flow,and apparent ruminal synthesis in lactating dairy cows[J].Journal of Dairy Science,2006,89(1):174-187.

[50] CASTAGNINO D S,YING Y,ALLEN M S,et al.Short communication:apparent ruminal synthesis of B vitamins in lactating dairy cows fed
Saccharomyces cerevisiae fermentation product[J].Journal of Dairy Science,2017,100(10):8161-8164.

[51] BEAUDET V,GERVAIS R,CHOUINARD P Y,et al.Effects of increasing amounts of extruded linseed in the diet on apparent ruminal synthesis of some B vitamins in dairy cows[J].Anima,2020,14(9):1885-1891.

[52] CASTAGNINO D S,KAMMES K L,ALLEN M S,et al.High-concentrate diets based on forages harvested at different maturity stages affect ruminal synthesis of B vitamins in lactating dairy cows[J].Animal,2017,11(4):608-615.

[53] SANTSCHI D E,BERTHIAUME R,MATTE J J,et al.Fate of supplementary B-vitamins in the gastrointestinal tract of dairy cows[J].Journal of Dairy Science,2005,88(6):2043-2054.

[54] CASTAGNINO D S,HARVATINE K J,ALLEN M S,et al.Short communication:effect of fatty acid supplements on apparent ruminal synthesis of B vitamins in lactating dairy cows[J].Journal of Dairy Science,2017,100(10):8165-8169.

[55] CASTAGNINO D S,SECK M,LONGUSKI R A,et al.Particle size and endosperm type of dry corn grain altered duodenal flow of B vitamins in lactating dairy cows[J].Journal of Dairy Science,2018,101(11):9841-9846.

[56] LARDINOIS C C,MILLS R C,ELVEHJEM C A,et al.Rumen synthesis of the vitamin B complex as influenced by ration composition[J].Journal of Dairy Science,1944,27(7):579-583.

[57] BELANCHE A,DOREAU M,EDWARDS J E,et al.Shifts in the rumen microbiota due to the type of carbohydrate and level of protein ingested by dairy cattle are associated with changes in rumen fermentation[J].The Journal of Nutrition,2012,142(9):1684-1692.

[58] WATANABE F,BITO T.Vitamin B
12 sources and microbial interaction[J].Experimental Biology and Medicine,2018,243(2):148-158.

[59] GIRARD C L,GRAULET B.Methods and approaches to estimate B vitamin status in dairy cows:knowledge,gaps and advances[J].Methods,2021,186:52-58.
[60] BRITO A,CHIQUETTE J,STABLER S P,et al.Supplementing lactating dairy cows with a vitamin B
12 precursor,5,6-dimethylbenzimidazole,increases the apparent ruminal synthesis of vitamin B12[J].Animal,2015,9(1):67-75.

[61] STEMME K,LEBZIEN P,FLACHOWSKY G,et al.The influence of an increased cobalt supply on ruminal parameters and microbial vitamin B
12 synthesis in the rumen of dairy cows[J].Archives of Animal Nutrition,2008,62(3):207-218.

[62] 王润莲,张微,张玉枝,等.不同钴水平对肉用绵羊瘤胃维生素B
12合成,瘤胃发酵及造血机能的影响[J].动物营养学报,2007,19(5):534-538. WANG R L,ZHANG W,ZHANG Y Z,et al.Effects of dietary cobalts on vitamin B
12 synthesis,rumen fermentation and blood parameters of sheep[J].Chinese Journal of Animal Nutrition,2007(5):534-538.(in Chinese)
[63] GAGNON D M,STICH T A,MEHTA A P,et al.An aminoimidazole radical intermediate in the anaerobic biosynthesis of the 5,6-dimethylbenzimidazole ligand to vitamin B
12[J].Journal of the American Chemical Society,2018,140(40):12798-12807.

[64] RICKARD T R,BIGGER G W,ELLIOT J M.Effects of 5,6-dimethylbenzimidazole,adenine and riboflavin on ruminal vitamin B
12 synthesis[J].Journal of Animal Science,1975,40(6):1199-1204.

[65] GIRARD C L,SANTSCHI D E,STABLER S P,et al.Apparent ruminal synthesis and intestinal disappearance of vitamin B
12 and its analogs in dairy cows[J].Journal of Dairy Science,2009,92(9):4524-4529.

[66] YOSHII K,HOSOMI K,SAWANE K,et al.Metabolism of dietary and microbial vitamin B family in the regulation of host immunity[J].Frontiers in Nutrition,2019,6:48.
[67] DRYWIEŃ M,FRACKIEWICZ J,GÓRNICKA M,et al.Effect of probiotic and storage time of thiamine and riboflavin content in the milk drinks fermented by Lactobacillus casei KNE-1[J].Roczniki Panstwowego Zakladu Higieny,2015,66(4):373-377.
[68] DEGUCHI Y,MORISHITA T,MUTAI M,et al.Comparative studies on synthesis of water-soluble vitamins among human species of bifidobacteria[J].Jounal Agricultural and Biological Chemistry,1985,49(1):13-19.
[69] GARCÍA-ANGULO V A.Overlapping riboflavin supply pathways in bacteria[J].Critical Reviews in Microbiology,2017,43(2):196-209.

[70] STAHMANN K P,REVUELTA J L,SEULBERGER H.Three biotechnical processes using
Ashbya gossypii,
Candida famata,or
Bacillus subtilis compete with chemical riboflavin production[J].Applied Microbiology and Biotechnology,2000,53(5):509-516.

[71] MAGNÚSDÓTTIR S,RAVCHEEV D,DE CRÉCY-LAGARD V,et al.Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes[J].Frontiers in Genetics,2015,6:148.
[72] RODIONOV D A,LI X,RODIONOVA I A,et al.Transcriptional regulation of NAD metabolism in bacteria:genomic reconstruction of NiaR (YrxA) regulon[J].Nucleic Acids Research,2008,36(6):2032-2046.

[73] AL-DILAIMI A,ALBERSMEIER A,KALINOWSKI J,et al.Complete genome sequence of
Corynebacterium vitaeruminis DSM 20294T,isolated from the cow rumen as a vitamin B producer[J].Journal of Biotechnology,2014,189:70-71.
[74] GANGADHARAN D,SIVARAMAKRISHNAN S,PANDEY A,et al.Folate roducing lactic acid bacteria from cow's milk with probiotic characteristics[J].International Journal of Dairy Technology,2010,63(3):339-348.

[75] FRANCO-LOPEZ J,DUPLESSIS M,BUI A,et al.Correlations between the composition of the bovine microbiota and vitamin B
12 abundance[J].mSystems,2020,5(2):e00107-e00120.