综述 REVIEW

动物肌肉组织蛋白质代谢调控的研究进展

  • 窦露 ,
  • 刘畅 ,
  • 杨致昊 ,
  • 靳烨
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  • 内蒙古农业大学食品科学与工程学院, 呼和浩特 010018
窦露(1995-),女,内蒙古巴彦淖尔人,博士研究生,研究方向为肉品科学与技术。E-mail:doulu118899@163.com

收稿日期: 2021-06-22

  网络出版日期: 2022-01-18

基金资助

国家自然科学基金资助项目(31660439);内蒙古自治区科技成果转化专项项目(2019CG066);内蒙古自治区自然科学基金重大专项项目(2020ZD11);内蒙古自然科学基金面上项目(2018MS03050);地区科学基金项目(32060519)

Research Progress on Regulation of Protein Metabolism in Animal Muscle Tissue

  • DOU Lu ,
  • LIU Chang ,
  • YANG Zhihao ,
  • JIN Ye
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  • College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2021-06-22

  Online published: 2022-01-18

摘要

动物肌肉蛋白质是维持机体功能的重要蛋白质,亦是影响肉品质特性的重要因素。研究表明,动物肌肉蛋白质代谢由胰岛素样生长因子-1(IGF-1)/磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、肿瘤坏死因子-α(TNF-α)/核转录因子-κB(NF-κB)和肌肉生长抑制素(MSTN)/Smadt等多条信号通路参与完成。此外,肌肉蛋白质代谢受到如miRNA、腺苷酸活化蛋白激酶(AMPK)、肠道微生物及脂肪酸的调控。因此,本文对肌肉蛋白质代谢的信号通路、调控机制及其对肉品质的影响进行系统地阐述,以期完善和丰富骨骼肌发育及代谢的网络调控机制,为今后通过遗传、营养等举措改善肉品质提供理论依据。

本文引用格式

窦露 , 刘畅 , 杨致昊 , 靳烨 . 动物肌肉组织蛋白质代谢调控的研究进展[J]. 动物营养学报, 2022 , 34(1) : 39 -50 . DOI: 10.3969/j.issn.1006-267x.2022.01.005

Abstract

Animal muscle protein is an important protein which maintains the normal physiological functions of the body, and it is also an important factor that affects the characteristics of meat quality. Studies have shown that animal muscle protein metabolism is completed by multiple signaling pathways such as insulin-like growth factor-1 (IGF-1)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), tumor necrosis factor-α (TNF-α)/nuclear transcription factor-κB (NF-κB) and myostatin (MSTN)/Smadt. In addition, muscle protein metabolism is regulated by miRNA, AMP-activated protein kinase (AMPK), intestinal microbes and fatty acid. Therefore, this article systematically elaborates on the signal pathways, regulation mechanisms of muscle protein metabolism and its effects on meat quality, in order to improve and enrich the network regulation mechanism of skeletal muscle development and metabolism, which will provide a theoretical basis for improving meat quality through genetic and nutrition measures in the future.

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