[1] 陈嘉序,陈如扬,连媛,等.大豆异黄酮的生物转化及功能活性研究进展[J].食品研究与开发,2021,42(9):176-182. CHEN J X,CHEN R Y,LIAN Y,et al.Progress in microbial conversion and functional activity of soy isoflavones[J].Food Research and Development,2021,42(9):176-182.(in Chinese)
[2] 付雪梅,王之盛,代天飞.大豆异黄酮的营养生理功能及其在动物生产中的应用[J].畜禽业,2006(18):10-13. FU X M,WANG Z S,DAI T F.Nutritional and physiological functions of soybean isoflavone and its application in animal production[J].Livestock and Poultry Industry,2006(18):10-13.(in Chinese)
[3] 任维利.大豆异黄酮的作用研究进展[J].食品安全导刊,2021(14):74-75. REN W L.Research progress on the effect of soybean isoflavone[J].China Food Safety Magazine,2021(14):74-75.(in Chinese)
[4] 郭静,周凯,蔡冬青.大豆异黄酮对大鼠的体液免疫调节作用[J].中西医结合心血管病电子杂志,2020,8(29):84-85. GUO J,ZHOU K,CAI D Q.Effects of soybean isoflavone on humoral immunity in rats[J].Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine,2020,8(29):84-85.(in Chinese)
[5] XIAO Y Q,ZHANG S,TONG H B,et al.Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades[J].Phytotherapy Research,2018,32(3):384-394.

[6] 姜淑妍.大豆异黄酮对高温下体外培养奶牛乳腺上皮细胞增殖和抗氧化能力的影响[J].中国饲料,2020(15):29-32. JIANG S Y.Effects of isoflavones on proliferation and antioxidation of bovine mammary epithelial cells cultures
in vitro under high temperature[J].China Feed,2020(15):29-32.(in Chinese)
[7] TSUGAMI Y,SUZUKI N,SUZUKI T,et al.Regulatory effects of soy isoflavones and their metabolites in milk production via different ways in mice[J].Journal of Agricultural and Food Chemistry,2020,68(21):5847-5853.

[8] LI Y P,JIANG X R,WEI Z X,et al.Effects of soybean isoflavones on the growth performance,intestinal morphology and antioxidative properties in pigs[J].Animal,2020,14(11):2262-2270.

[9] 常化松,袁雯雯,玄红专,等.黄酮类化合物吸收代谢及其对胃肠道功能影响的研究进展[J].食品工业科技,2019,40(18):340-347. CHANG H S,YUAN W W,XUAN H Z,et al.Research progress on absorption and metabolism of flavonoids and their effects on the gastrointestinal tract function[J].Science and Technology of Food Industry,2019,40(18):340-347.(in Chinese)
[10] 施洋,候宝林,吴胜利,等.植物雌激素的研究进展[J].亚太传统医药,2019,15(11):172-176. SHI Y,HOU B L,WU S L,et al.Research advancement of phytoestrogen[J].Asia-Pacific Traditional Medicine,2019,15(11):172-176.(in Chinese)
[11] ELDRIDGE A C,KWOLEK W F.Soybean isoflavones:effect of environment and variety on composition[J].Journal of Agricultural and Food Chemistry,1983,31(2):394-396.

[12] 殷丽君,李里特,李再贵,等.大豆异黄酮的研究近况与展望[J].食品科学,2002,23(4):152-154. YIN L J,LI L D,LI Z G,et al.Development and expectation of research on soybean isoflavone[J].Food Science,2002,23(4):152-154.(in Chinese)
[13] 王继峰.大豆异黄酮的保健功效及高异黄酮大豆的遗传育种研究[J].黑龙江科学,2019,10(14):42-43. WANG J F.Study on health function of soybean isoflavones and genetics and breeding of soybean with high isoflavones[J].Heilongjiang Science,2019,10(14):42-43.(in Chinese)
[14] 黄金昌.大豆异黄酮对种鸭生理机能调控的研究进展[J].湖南饲料,2015(5):20-23. HUANG J C.Research progress on physiological function regulation of soybean isoflavones in breeding ducks[J].Hunan Feed,2015(5):20-23.(in Chinese)
[15] 石群,李波.大豆异黄酮研究进展及前景展望[J].大豆科技,2018(5):37-39. SHI Q,LI B.Research progress and prospect of soybean isoflavones[J].Soybean Science & Technology,2018(5):37-39.(in Chinese)
[16] 林执绚.超高压提取技术对葛根异黄酮提取率的影响[J].化学工程与装备,2009(2):36-37. LIN Z X.Effects of ultra-high pressure extraction technology on extraction rate of isoflavone from
Pueraria root[J].Fujian Chemical Industry,2009(2):36-37.(in Chinese)
[17] 潘利华,罗建平.大豆异黄酮超临界流体萃取工艺与动力学模型[J].农业机械学报,2010,41(6):137-141. PAN L H,LUO J P.Process and kinetics of supercritical fluid extraction for soybean isoflavones[J].Transactions of the Chinese Society for Agricultural Machinery,2010,41(6):137-141.(in Chinese)
[18] 阮洪生,毛越,王海燕,等.豆粕中大豆异黄酮的醇提工艺[J].粮油食品科技,2007,15(3):35-36. RUAN H S,MAO Y,WANG H Y,et al.The study on alcohol extraction of soybean isoflavones from soybean residue[J].Science and Technology of Cereals,Oils and Foods,2007,15(3):35-36.(in Chinese)
[19] 郭婕,刘中华,袁淑培,等.黑豆中大豆异黄酮微波提取工艺的优化[J].食品工业科技,2015,36(5):255-257,305. GUO J,LIU Z H,YUAN S P,et al.Optimization of microwave-assisted extraction technology of soybean isoflavones from black soybean[J].Science and Technology of Food Industry,2015,36(5):255-257,305.(in Chinese)
[20] 陈燕.黑豆中提取大豆异黄酮研究[J].当代化工,2019,48(1):74-76,91. CHEN Y.Extraction of soybean isoflavones from black soybeans[J].Contemporary Chemical Industry,2019,48(1):74-76,91.(in Chinese)
[21] 王丹.脱脂豆粕中大豆异黄酮提取工艺的研究[J].食品研究与开发,2017,38(6):52-55. WANG D.Study on the extraction technology of isoflavones from defatted soybean meal[J].Food Research and Development,2017,38(6):52-55.(in Chinese)
[22] 张月洁,兰韬,初侨,等.大豆异黄酮的制备技术与功能活性进展研究[J].食品安全质量检测学报,2020,11(17):5964-5970. ZHANG Y J,LAN T,CHU Q,et al.Progress in preparation technology and functional activity of soybean isoflavones[J].Journal of Food Safety & Quality,2020,11(17):5964-5970.(in Chinese)
[23] 王双侠,苏适,柴宝丽.黑豆中大豆异黄酮超声波法提取工艺优化[J].齐齐哈尔大学学报(自然科学版),2021,37(2):70-72. WANG S X,SU S,CHAI B L.Optimization of ultrasonic extraction on soy isoflavones from back beans[J].Journal of Qiqihar University (Natural Science Edition),2021,37(2):70-72.(in Chinese)
[24] 周文红,郭咪咪,李秀娟,等.大豆异黄酮提取及其生物转化的研究进展[J].粮油食品科技,2019,27(5):37-42. ZHOU W H,GUO M M,LI X J,et al.Research progress of extraction and biotransformation of soybean isoflavones[J].Science and Technology of Cereals,Oils and Foods,2019,27(5):37-42.(in Chinese)
[25] SOUKUP S T,HELPPI J,MVLLER D R,et al.Phase Ⅱ metabolism of the soy isoflavones genistein and daidzein in humans,rats and mice:a cross-species and sex comparison[J].Archives of Toxicology,2016,90(6):1335-1347.

[26] KULLING S E,LEHMANN L,METZLER M.Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens[J].Journal of Chromatography B:Analytical Technologies in the Biomedical and Life Sciences,2002,777(1/2):211-218.
[27] FRANKE A A,LAI J F,HALM B M.Absorption,distribution,metabolism,and excretion of isoflavonoids after soy intake[J].Archives of Biochemistry and Biophysics,2014,559:24-28.
[28] SÁNCHEZ-CALVO J M,RODRÍGUEZ-IGLESIAS M A,MOLINILLO J M,et al.Soy isoflavones and their relationship with microflora:beneficial effects on human health in equol producers[J].Phytochemistry Reviews,2013,12(4):979-1000.

[29] LIU Y,HU M.Absorption and metabolism of flavonoids in the Caco-2 cell culture model and a perused rat intestinal model[J].Drug Metabolism and Disposition,2002,30(4):370-377.

[30] WALSH K R,HAAK S J,BOHN T,et al.Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies[J].American Journal of Clinical Nutrition,2007,85(4):1050-1056.

[31] DAY A J,DUPONT M S,RIDLEY S,et al.Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity[J].FEBS Letters,1998,436(1):71-75.

[32] ISLAM M A,PUNT A,SPENKELINK B,et al.Conversion of major soy isoflavone glucosides and aglycones in
in vitro intestinal models[J].Molecular Nutrition & Food Research,2014,58(3):503-515.

[33] BARNES S,PRASAIN J,D'ALESSANDRO T,et al.The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems[J].Food & Function,2011,2(5):235-244.

[34] TURNER N J,THOMSON B M,SHAW I C.Bioactive isoflavones in functional foods:the importance of gut microflora on bioavailability[J].Nutrition Reviews,2003,61(6):204-213.

[35] VITALE D C,PIAZZA C,MELILLI B,et al.Isoflavones:estrogenic activity,biological effect and bioavailability[J].European Journal of Drug Metabolism and Pharmacokinetics,2013,38(1):15-25.

[36] YUAN J P,WANG J H,LIU X.Metabolism of dietary soy isoflavones to equol by human intestinal microflora-implications for health[J].Molecular Nutrition & Food Research,2007,51(7):765-781.

[37] DAY A J,CAÑADA F J,DÍAZ J C,et al.Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase[J].FEBS Letters,2000,468(2/3):166-170.
[38] XU X,WANG H J,MURPHY P A,et al.Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women[J].The Journal of Nutrition,1994,124(6):825-832.

[39] SETCHELL K D,BROWN N M,DESAI P,et al.Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements[J].The Journal of Nutrition,2001,131(Suppl.4):1362S-1375S.
[40] XU X,HARRIS K S,WANG H J,et al.Bioavailability of soybean isoflavones depends upon gut microflora in women[J].The Journal of Nutrition,1995,125(9):2307-2315.

[41] LARKIN T,PRICE W E,ASTHEIMER L.The key importance of soy isoflavone bioavailability to understanding health benefits[J].Critical Reviews in Food Science and Nutrition,2008,48(6):538-552.

[42] RAFII F.The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol[J].Metabolites,2015,5(1):56-73.

[43] PABICH M,MATERSKA M.Biological effect of soy isoflavones in the prevention of civilization diseases[J].Nutrients,2019,11(7):1660.
[44] HVSER S,GUTH S,JOOST H G,et al.Effects of isoflavones on breast tissue and the thyroid hormone system in humans:a comprehensive safety evaluation[J].Archives of Toxicology,2018,92(9):2703-2748.

[45] YUAN B,WANG L L,JIN Y,et al.Role of metabolism in the effects of genistein and its phase Ⅱ conjugates on the growth of human breast cell lines[J].The AAPS Journal,2012,14(2):329-344.

[46] TORO-FUNES N,MORALES-GUTIÉRREZ F J,VECIANA-NOGUÉS M T,et al.The intracellular metabolism of isoflavones in endothelial cells[J].Food & Function,2015,6(1):98-108.
[47] KULLING S E,HONIG D M,METZLER M.Oxidative metabolism of the soy isoflavones daidzein and genistein in humans
in vitro and
in vivo[J].Journal of Agricultural and Food Chemistry,2001,49(6):3024-3033.

[48] ROWLAND I,FAUGHNAN M,HOEY L,et al.Bioavailability of phyto-oestrogens[J].British Journal of Nutrition,2003,89(Suppl.1):S45-S58.
[49] YASUDA T,KANO Y,SAITO K,et al.Urinary and biliary metabolites of daidzin and daidzein in rats[J].Biological & Pharmaceutical Bulletin,1994,17(10):1369-1374.

[50] 黄娜,尤春玲.大豆异黄酮代谢产物——雌马酚的功能作用研究[J].农产品加工学刊,2008(3):50-53. HUANG N,YOU C L.Progress in research of equol:a metabolite of the isoflavone daidzein[J].Academic Periodical of Farm Products Processing,2008(3):50-53.(in Chinese)
[51] ATKINSON C,FRANKENFELD C L,LAMPE J W.Gut bacterial metabolism of the soy isoflavone daidzein:exploring the relevance to human health[J].Experimental Biology and Medicine,2005,230(3):155-170.

[52] KULLING S E,HONIG D M,SIMAT T J,et al.Oxidative
in vitro metabolism of the soy phytoestrogens daidzein and genistein[J].Journal of Agricultural and Food Chemistry,2000,48(10):4963-4972.

[53] 葛蔚,张忠远,刘树欣.饲料添加剂大豆异黄酮研究[J].中国饲料,2004(7):24-25,28. GE W,ZHANG Z Y,LIU S X.Study on soybean isoflavone as feed additive[J].China Feed,2004(7):24-25,28.(in Chinese)
[54] MAYO B,VÁZQUEZ L,FLÓREZ A B.Equol:a bacterial metabolite from the daidzein isoflavone and its presumed beneficial health effects[J].Nutrients,2019,11(9):2231.
[55] TAMURA M,TSUSHIDA T,SHINOHARA K.Isolation of an isoflavone-metabolizing,
Clostridium-like bacterium,strain TM-40,from human faeces[J].Anaerobe,2007,13(1):32-35.

[56] SHIMADA Y,TAKAHASHI M,MIYAZAWA N,et al.Identification of two novel reductases involved in equol biosynthesis in
Lactococcus strain 20-92[J].Journal of Molecular Microbiology and Biotechnology,2011,21(3/4):160-172.
[57] SHIMADA Y,YASUDA S,TAKAHASHI M,et al.Cloning and expression of a novel NADP(H)-dependent daidzein reductase,an enzyme involved in the metabolism of daidzein,from equol-producing
Lactococcus strain 20-92[J].Applied and Environmental Microbiology,2010,76(17):5892-5901.

[58] SCHOEFER L,MOHAN R,BRAUNE A,et al.Anaerobic C-ring cleavage of genistein and daidzein by
Eubacterium ramulus[J].FEMS Microbiology Letters,2002,208(2):197-202.

[59] GAYA P,PEIROTÉN Á,MEDINA M,et al.
Bifidobacterium adolescentis INIA P784:the first probiotic bacterium capable of producing enterodiol from lignan extracts[J].Journal of Functional Foods,2017,29:269-274.
[60] ELGHALI S,MUSTAFA S,AMID M,et al.Bioconversion of daidzein to equol by
Bifidobacterium breve 15700 and
Bifidobacterium longum BB536[J].Journal of Functional Foods,2012,4(4):736-745.

[61] MATTHIES A,BLAUT M,BRAUNE A.Isolation of a human intestinal bacterium capable of daidzein and genistein conversion[J].Applied and Environmental Microbiology,2009,75(6):1740-1744.

[62] YURIST-DOUTSCH S,ARRIETA M C,VOGT S L,et al.Gastrointestinal microbiota-mediated control of enteric pathogens[J].Annual Review of Genetics,2014,48:361-382.
[63] VÁZQUEZ L,FLÓREZ A B,GUADAMURO L,et al.Effect of soy isoflavones on growth of representative bacterial species from the human gut[J].Nutrients,2017,9(7):727.
[64] 王海涛.大豆异黄酮的抑菌活性及其机制的研究[D].硕士学位论文.大连:辽宁师范大学,2009. WANG H T.Anti-microoganism activity and anti-microbial mechanism of soybean isoflavone[D].Master's Thesis.Dalian:Liaoning Normal University,2009.(in Chinese)
[65] TOUSEN Y,MATSUMOTO Y,MATSUMOTO C,et al.The combined effects of soya isoflavones and resistant starch on equol production and trabecular bone loss in ovariectomised mice[J].British Journal of Nutrition,2016,116(2):247-257.

[66] KASPAROVSKA J,PECINKOVA M,DADAKOVA K,et al.Effects of isoflavone-enriched feed on the rumen microbiota in dairy cows[J].PLoS One,2016,11(4):e0154642.
[67] GAYA P,PEIROTÉN Á,MEDINA M,et al.Isoflavone metabolism by a collection of lactic acid bacteria and
Bifidobacteria with biotechnological interest[J].International Journal of Food Sciences and Nutrition,2016,67(2):117-124.

[68] HONG H,LANDAUER M R,FORISKA M A,et al.Antibacterial activity of the soy isoflavone genistein[J].Journal of Basic Microbiology,2006,46(4):329-335.

[69] 王亚梅,贾漪涛,李中信.肠神经胶质细胞在肠道功能与肠道疾病中的作用[J].世界华人消化杂志,2020,28(19):979-985. WANG Y M,JIA Y T,LI Z X.Role of enteric glial cells in intestinal function and intestinal diseases[J].World Chinese Journal of Digestology,2020,28(19):979-985.(in Chinese)
[70] FOONG D,ZHOU J,ZARROUK A,et al.Understanding the biology of human interstitial cells of Cajal in gastrointestinal motility[J].International Journal of Molecular Sciences,2020,21(12):4540.
[71] GHARZOULI K,HOLZER P.Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin,naringenin,apigenin and genistein[J].Pharmacology,2004,70(1):5-14.

[72] SHIN D H,LEE M J,JIAO H Y,et al.Regulatory roles of endogenous mitogen-activated protein kinases and tyrosine kinases in the pacemaker activity of colonic interstitial cells of Cajal[J].Pharmacology,2015,96(1/2):16-24.
[73] AMIRA S,ROTONDO A,MULō F.Relaxant effects of flavonoids on the mouse isolated stomach:structure-activity relationships[J].European Journal of Pharmacology,2008,599(1/3):126-130.
[74] LORD R,FAIRBOURN N,MYLAVARAPU C,et al.Consuming genistein improves survival rates in the absence of laxative in ΔF508-CF female mice[J].Nutrients,2018,10(10):1418.
[75] SANTOS-FAGUNDES D,GRASA L,GONZALO S,et al.Different mechanisms of actions of genistein,quercetin on spontaneous contractions of rabbit duodenum[J].Revista Espanola de Enfermedades Digestivas,2015,107(7):413-416.
[76] SUZUKI T.Regulation of the intestinal barrier by nutrients:the role of tight junctions[J].Animal Science Journal,2020,91(1):e13357.
[77] MCCARTY M F,LERNER A.Perspective:prospects for nutraceutical support of intestinal barrier function[J].Advances in Nutrition,2021,12(2):316-324.

[78] LV Z P,DAI H J,WEI Q W,et al.Dietary genistein supplementation protects against lipopolysaccharide-induced intestinal injury through altering transcriptomic profile[J].Poultry Science,2020,99(7):3411-3427.

[79] JEONG J W,LEE H H,HAN M H,et al.Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia[J].Chemico-Biological Interactions,2014,212:30-39.
[80] CHACKO B K,CHANDLER R T,MUNDHEKAR A,et al.Revealing anti-inflammatory mechanisms of soy isoflavones by flow:modulation of leukocyte-endothelial cell interactions[J].American Journal of Physiology:Heart and Circulatory Physiology,2005,289(2):H908-H915.
[81] ZHU C,WU Y P,JIANG Z Y,et al.Dietary soy isoflavone attenuated growth performance and intestinal barrier functions in weaned piglets challenged with lipopolysaccharide[J].International Immunopharmacology,2015,28(1):288-294.

[82] 程东静.大豆异黄酮对高脂肥胖大鼠结肠屏障功能的影响[D].硕士学位论文.雅安:四川农业大学,2019. CHENG D J.Improvement of colonic barrier function with soy isoflavones in high-fat diet induced obese in rats[D].Master's Thesis.Ya'an:Sichuan Agricultural University,2019.(in Chinese)
[83] LI S S,ZHENG M,ZHANG Z T,et al.Galli gigeriae endothelium corneum:its intestinal barrier protective activity
in vitro and chemical composition[J].Chinese Medicine,2021,16(1):22.