综述 REVIEW

调控Hippo通路的因子及其研究方法

  • 覃怡琅 ,
  • 王佳堃 ,
  • 杨斌
展开
  • 1. 浙江大学奶业科学研究所, 杭州 310013;
    2. 浙江科技学院生物与化学工程学院, 杭州 310023
覃怡琅(1997-),女,四川遂宁人,硕士研究生,从事动物营养与饲料科学研究。E-mail:qinyilang197@163.com

收稿日期: 2021-12-26

  网络出版日期: 2022-07-14

基金资助

国家自然科学基金项目(32002198);浙江省自然科学基金项目(D21C170001)

Factors for Regulating Hippo Pathway and Their Research Methods

  • QIN Yilang ,
  • WANG Jiakun ,
  • YANG Bin
Expand
  • 1. Institute of Dairy Science, Zhejiang University, Hangzhou 310013, China;
    2. School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China

Received date: 2021-12-26

  Online published: 2022-07-14

摘要

Hippo通路是由核心激酶、效应因子、辅助因子和转录因子共同组成的激酶级联反应链,调控细胞的生长、代谢和信号转导等重要过程。跨膜蛋白、机械信号、G蛋白偶联受体、营养素等均能调控Hippo通路。通过条件性小鼠敲除模型和使用靶向性化学制剂,研究人员发现姜黄素、叶酸、白藜芦醇等通过Hippo通路发挥调控细胞发育的作用,即Hippo信号通路在营养素调控动物生长方面扮演重要角色。为此本文对Hippo通路的组成、作用模式、调控因子和目前的研究方法进行综述,以期为Hippo通路在畜牧生产上的研究提供支持。

本文引用格式

覃怡琅 , 王佳堃 , 杨斌 . 调控Hippo通路的因子及其研究方法[J]. 动物营养学报, 2022 , 34(7) : 4200 -4212 . DOI: 10.3969/j.issn.1006-267x.2022.07.013

Abstract

The Hippo pathway is a kinase cascade reaction chain composed of core kinases, effectors, cofactors, and transcription factors, which regulates important processes such as cell growth, metabolism, and signal transduction. Factors including transmembrane proteins, mechanical signals, G protein-coupled receptors and nutrients are involved in the regulation of Hippo pathway. Using the conditional mouse knockout models and specific chemical agents, some nutritive substances including curcumin, folic acid and resveratrol are reposted to regulate cell development through the Hippo pathway. Thus, the Hippo signaling pathway can play an important role in nutrient regulation of animal growth. In the present paper, we reviewed the composition, mode of action, regulatory factors and current research methods of the Hippo pathway, in order to provide support for the research on the Hippo pathway in animal husbandry production.

参考文献

[1] HONG W J,GUAN K L.The YAP and TAZ transcription co-activators:key downstream effectors of the mammalian Hippo pathway[J].Seminars in Cell & Developmental Biology,2012,23(7):785-793.  
[2] MENG Z P,MOROISHI T,MOTTIER-PAVIE V,et al.MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway[J].Nature Communications,2015,6(1):8357.
[3] ZHANG L,TANG F Y,TERRACCIANO L,et al.NDR functions as a physiological YAP1 kinase in the intestinal epithelium[J].Current Biology,2015,25(3):296-305.
[4] LIN C W,YAO E,CHUANG P T.A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth[J].Developmental Biology,2015,403(1):101-113.
[5] LIU M,ZHAO S Y,LIN Q J,et al.YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues[J].Molecular and Cellular Biology,2015,35(8):1449-1461.
[6] NISHIO M,SUGIMACHI K,GOTO H,et al.Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice[J].Proceedings of the National Academy of Sciences of the United States of America,2016,113(1):E71-E80.
[7] WANG X H,FREIRE VALLS A, SCHERMANN G,et al.YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis[J].Developmental Cell,2017,42(5):462-478.e7.
[8] JI S Y,LIU Q X,ZHANG S H,et al.FGF15 activates Hippo signaling to suppress bile acid metabolism and liver tumorigenesis[J].Developmental Cell,2019,48(4):460-474.e9.
[9] LITTLE D R,LYNCH A M,YAN Y,et al.Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo[J].Nature Communications,2021,12(1):2509.
[10] KIM N G,GUMBINER B M.Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway[J].The Journal of Cell Biology,2015,210(3):503-515.
[11] XU X M,NIE J,LU L,et al.YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer[J].Journal of Cellular and Molecular Medicine,2021,25(5):2584-2595.
[12] DRISKILL J H,ZHENG Y G,WU B K,et al.WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma[J].Genes & Development,2021,35(7/8):495-511.
[13] XIAO Q Q,QIAN Z L,ZHANG W Q,et al.Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation[J].Oncotarget,2016,7(8):9513-9524.
[14] ZHAO R,FALLON T R,SALADI S V,et al.Yap tunes airway epithelial size and architecture by regulating the identity,maintenance,and self-renewal of stem cells[J].Developmental Cell,2014,30(2):151-165.
[15] GRVNDL M,WALZ S,HAUF L,et al.Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes[J].PLoS Genetics,2020,16(5):e1008818.
[16] MISKOLCZI Z,SMITH M P,ROWLING E J,et al.Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing[J].Oncogene,2018,37(23):3166-3182.
[17] ZHANG T Q,ZHANG K P,JI K Y,et al.MicroRNA-365 inhibits YAP through TLR4-mediated IRF3 phosphorylation and thereby alleviates gastric precancerous lesions[J].Cancer Cell International,2020,20(1):549.
[18] YING J,WANG P E,ZHANG S X,et al.Transforming growth factor-beta1 promotes articular cartilage repair through canonical Smad and Hippo pathways in bone mesenchymal stem cells[J].Life Sciences,2018,192:84-90.
[19] LI Q,SUN Y,JARUGUMILLI G K,et al.Lats1/2 sustain intestinal stem cells and Wnt activation through TEAD-dependent and independent transcription[J].Cell Stem Cell,2020,26(5):675-692.e8.
[20] SHAH S R,DAVID J M,TIPPENS N D,et al.Brachyury-YAP regulatory axis drives stemness and growth in cancer[J].Cell Reports,2017,21(2):495-507.
[21] SZETO S G,NARIMATSU M,LU M L,et al.YAP/TAZ are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis[J].Journal of the American Society of Nephrology,2016,27(10):3117-3128.
[22] KOINIS F,CORN P,PARIKH N,et al.Resistance to MET/VEGFR2 inhibition by cabozantinib is mediated by YAP/TBX5-dependent induction of FGFR1 in castration-resistant prostate cancer[J].Cancers,2020,12(1):244.
[23] WEI W,XUE L L,TAN L Y,et al.Inhibition of yes-associated protein dephosphorylation prevents aggravated periodontitis with occlusal trauma[J].Journal of Periodontology,2021,92(7):1036-1048.
[24] MCGINN J,HALLOU A,HAN S,et al.A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium[J].Nature Cell Biology,2021,23(5):511-525.
[25] SHAO D,ZHAI P Y,DEL RE D P,et al.A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response[J].Nature Communications,2014,5:3315.
[26] YUAN F,WANG J L,LI R X,et al.A new regulatory mechanism between P53 and YAP crosstalk by SIRT1 mediated deacetylation to regulate cell cycle and apoptosis in A549 cell lines[J].Cancer Management and Research,2019,11:8619-8633.
[27] MOHSENI M,SUN J L,LAU A,et al.A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway[J].Nature Cell Biology,2014,16(1):108-117.
[28] YU J Z,ZHENG Y G,DONG J X,et al.Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded[J].Developmental Cell,2010,18(2):288-299.
[29] LING C,ZHENG Y G,YIN F,et al.The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to expanded[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(23):10532-10537.
[30] MATSUDA T,ZHAI P Y,SCIARRETTA S,et al.NF2 activates Hippo signaling and promotes ischemia/reperfusion injury in the heart[J].Circulation Research,2016,119(5):596-606.
[31] FANG C Y,LAI T C,HSIAO M,et al.The diverse roles of TAO kinases in health and diseases[J].International Journal of Molecular Sciences,2020,21(20):7463.
[32] WILSON K E,LI Y W,YANG N,et al.PTPN14 forms a complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function[J].The Journal of Biological Chemistry,2014,289(34):23693-23700.
[33] YUAN L S,MAO Y,LUO W,et al.Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism[J].The Journal of Biological Chemistry,2017,292(36):15002-15015.
[34] BAE S J,NI L S,LUO X L.STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism[J].eLife,2020,9:e54863.
[35] SEO G,HAN H,VARGAS R E,et al.MAP4K interactome reveals STRN4 as a key STRIPAK complex component in Hippo pathway regulation[J].Cell Reports,2020,32(1):107860.
[36] ZHANG Y L,LI Q,YANG X M,et al.SPON2 promotes M1-like macrophage recruitment and inhibits hepatocellular carcinoma metastasis by distinct integrin-Rho GTPase-Hippo pathways[J].Cancer Research,2018,78(9):2305-2317.
[37] IBAR C,IRVINE K D.Integration of Hippo-YAP signaling with metabolism[J].Developmental Cell,2020,54(2):256-267.
[38] YE J,LI T S,XU G,et al.JCAD promotes progression of nonalcoholic steatohepatitis to liver cancer by inhibiting LATS2 kinase activity[J].Cancer Research,2017,77(19):5287-5300.
[39] SHIELDS C E,POTLAPALLI S,CUYA-SMITH S M,et al.Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target[J].Molecular Oncology,2021,15(8):2156-2171.
[40] HABBIG S,BARTRAM M P,MVLLER R U,et al.NPHP4,a cilia-associated protein,negatively regulates the Hippo pathway[J].The Journal of Cell Biology,2011,193(4):633-642.
[41] ZHENG X,CHEN L J,ZHOU Y,et al.A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling[J].Molecular Cancer,2019,18(1):47.
[42] WEHR M C,HOLDER M V,GAILITE I,et al.Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila[J].Nature Cell Biology,2013,15(1):61-71.
[43] IWASA H,HOSSAIN S,HATA Y.Tumor suppressor C-RASSF proteins[J].Cellular and Molecular Life Sciences,2018,75(10):1773-1787.
[44] AZAD T,NOURI K,JANSE VAN RENSBURG H J,et al.A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis[J].Oncogene,2020,39(2):334-355.
[45] YU F X,ZHAO B,PANUPINTHU N,et al.Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling[J].Cell,2012,150(4):780-791.
[46] MA Y W,WANG L H,HE F L,et al.LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction[J].Cancer Letters,2021,506:67-82.
[47] HUANG S S,CAO Y,GUO H,et al.Up-regulated acylglycerol kinase (AGK) expression associates with gastric cancer progression through the formation of a novel YAP1-AGK-positive loop[J].Journal of Cellular and Molecular Medicine,2020,24(19):11133-11145.
[48] HUANG Z H,SUN D,HU J X,et al.Neogenin promotes BMP2 activation of YAP and Smad1 and enhances astrocytic differentiation in developing mouse neocortex[J].Journal of Neuroscience,2016,36(21):5833-5849.
[49] PULKKINEN H H,KIEMA M,LAPPALAINEN J P,et al.BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF[J].Angiogenesis,2021,24(1):129-144.
[50] KIM J,KWON H,SHIN Y K,et al.MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2020,117(24):13529-13540.
[51] VERMA N K,GADI A,MAURIZI G,et al.Myeloid zinc finger 1 and GA binding protein co-operate with Sox2 in regulating the expression of yes-associated protein 1 in cancer cells[J].Stem Cells,2017,35(12):2340-2350.
[52] MIAO J B,KYOYAMA H,LIU L W,et al.Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells[J].Journal of Cellular and Molecular Medicine,2020,24(1):1087-1098.
[53] GONZÁLEZ-MARISCAL L,GALLEGO-GUTIÉRREZ H,GONZÁLEZ-GONZÁLEZ L,et al.ZO-2 is a master regulator of gene expression,cell proliferation,cytoarchitecture,and cell size[J].International Journal of Molecular Sciences,2019,20(17):4128.
[54] CAI X M,WANG K C,MENG Z P.Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression[J].Frontiers in Cell and Developmental Biology,2021,9:673599.
[55] DENG H,WANG W,YU J Z,et al.Spectrin regulates Hippo signaling by modulating cortical actomyosin activity[J].eLife,2015,4:e06567.
[56] FLETCHER G C,ELBEDIWY A,KHANAL I,et al.The spectrin cytoskeleton regulates the hippo signalling pathway[J].The EMBO Journal,2015,34(7):940-954.
[57] NAWAZ Z,PATIL V,ARORA A,et al.Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription[J].Scientific Reports,2016,6(1):27753.
[58] LEE J S,PARK H W,CHO K J,et al.Sestrin2 inhibits YAP activation and negatively regulates corneal epithelial cell proliferation[J].Experimental & Molecular Medicine,2020,52(6):951-962.
[59] JIAO S,WANG H Z,SHI Z B,et al.A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer[J].Cancer Cell,2014,25(2):166-180.
[60] CLARKE L E,COOK A,MATHAVARAJAH S,et al.Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition[J].FASEB Journal,2021,35(11):e22001.
[61] JIA L L,ZHANG Y P,JI Y W,et al.YAP balances the osteogenic and adipogenic differentiation of hPDLSCs in vitro partly through the Wnt/β-catenin signaling pathway[J].Biochemical and Biophysical Research Communications,2019,518(1):154-160.
[62] ZHOU D W,CONRAD C,XIA F,et al.Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene[J].Cancer Cell,2009,16(5):425-438.
[63] LEE J H,KIM T S,YANG T H,et al.A crucial role of WW45 in developing epithelial tissues in the mouse[J].The EMBO Journal,2008,27(8):1231-1242.
[64] NISHIO M,HAMADA K,KAWAHARA K,et al.Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice[J].The Journal of Clinical Investigation,2012,122(12):4505-4518.
[65] SINGH K,PRUSKI M A,POLIREDDY K,et al.Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer[J].Oncogene,2020,39(5):1152-1164.
[66] LI W L,DENG Y J,FENG B,et al.Mst1/2 kinases modulate glucose uptake for osteoblast differentiation and bone formation[J].Journal of Bone and Mineral Research,2018,33(6):1183-1195.
[67] DENG Y J,LU J Q,LI W L,et al.Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation[J].Nature Communications,2018,9(1):4564.
[68] MENG C L,TIAN G,XU C H,et al.Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway[J].Cell Death and Differentiation,2020,27(10):2797-2809.
[69] WANG P,GENG J,GAO J H,et al.Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis[J].Nature Communications,2019,10(1):755.
[70] LEUNG J Y,WILSON H L,VOLTZKE K J,et al.Sav1 loss induces senescence and Stat3 activation coinciding with tubulointerstitial fibrosis[J].Molecular and Cellular Biology,2017,37(12):e00565-16.
[71] KAI T,TSUKAMOTO Y,HIJIYA N,et al.Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway[J].The Journal of Pathology,2016,239(1):97-108.
[72] JEONG S H,KIM H B,KIM M C,et al.Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer[J].The Journal of Clinical Investigation,2018,128(3):1010-1025.
[73] TAMURA T,KODAMA T,SATO K,et al.Dysregulation of PI3K and hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation[J].The Journal of Clinical Investigation,2021,131(13):143414.
[74] ZHANG X Y,GUO C,WU X W,et al.Analysis of liver tumor-prone mouse models of the hippo kinase scaffold proteins RASSF1A and SAV1[J].Cancer Research,2016,76(9):2824-2835.
[75] COTTON J L,LI Q,MA L F,et al.YAP/TAZ and hedgehog coordinate growth and patterning in gastrointestinal mesenchyme[J].Developmental Cell,2017,43(1):35-47.e4.
[76] GUILLERMIN O,ANGELIS N,SIDOR C M,et al.Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration[J].The EMBO Journal,2021,40(13):e105770.
[77] HONG S P,YANG M J,CHO H,et al.Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi[J].Nature Communications,2020,11(1):4102.
[78] CHEUNG P,XIOL J,DILL M T,et al.Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer[J].Cell Stem Cell,2020,27(4):590-604.e9.
[79] WU L M N,DENG Y Q,WANG J C,et al.Programming of Schwann cells by Lats1/2-TAZ/YAP signaling drives malignant peripheral nerve sheath tumorigenesis[J].Cancer Cell,2018,33(2):292-308.e7.
[80] CHEN Z G,LI S,MO J,et al.Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling[J].JCI Insight,2020,5(20):e141514.
[81] NANTIE L B,YOUNG R E,PALTZER W G,et al.Lats1/2 inactivation reveals Hippo function in alveolar type Ⅰ cell differentiation during lung transition to air breathing[J].Development,2018,145(21):dev163105.
[82] PARK J,KIM J S,NAHM J H,et al.WWC1 and NF2 prevent the development of intrahepatic cholangiocarcinoma by regulating YAP/TAZ activity through LATS in mice[J].Molecules and Cells,2020,43(5):491-499.
[83] XIAO Y,HILL M C,LI L L,et al.Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis[J].Genes & Development,2019,33(21/22):1491-1505.
[84] BAE J S,JEON Y,KIM S M,et al.Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling[J].Cell Death & Disease,2018,9(11):1083.
[85] OMORI H,NISHIO M,MASUDA M,et al.YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma[J].Science Advances,2020,6(12):eaay3324.
[86] OTSUBO K,GOTO H,NISHIO M,et al.MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation,adhesion and tumour formation[J].Oncogene,2017,36(29):4201-4211.
[87] GOTO H,NISHIO M,TO Y,et al.Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9[J].Development,2018,145(6):dev159244.
[88] XIN M,KIM Y,SUTHERLAND L B,et al.Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size[J].Science Signaling,2011,4(196):ra70.
[89] XIN M,KIM Y,SUTHERLAND L B,et al.Hippo pathway effector Yap promotes cardiac regeneration[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(34):13839-13844.
[90] BYUN J,DEL RE D P,ZHAI P Y,et al.Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload[J].The Journal of Biological Chemistry,2019,294(10):3603-3617.
[91] ISAGO H,MITANI A,MIKAMI Y,et al.Epithelial expression of YAP and TAZ is sequentially required in lung development[J].American Journal of Respiratory Cell and Molecular Biology,2020,62(2):256-266.
[92] AI L Q Y,YUAN R D,CHEN X,et al.Retinal blood vessel-origin yes-associated protein (YAP) governs astrocytic maturation via leukaemia inhibitory factor (LIF)[J].Cell Proliferation,2020,53(2):e12757.
[93] DAI Y J,HAO P,SUN Z M,et al.Liver knockout YAP gene improved insulin resistance-induced hepatic fibrosis[J].Journal of Endocrinology,2021,249(2):149-161.
[94] LEE Y A,NOON L A,AKAT K M,et al.Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap[J].Nature Communications,2018,9(1):4962.
[95] ZHAO K,SHEN C Y,LU Y S,et al.Muscle Yap is a regulator of neuromuscular junction formation and regeneration[J].Journal of Neuroscience,2017,37(13):3465-3477.
[96] HUANG Z H,HU J X,PAN J X,et al.YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation[J].Development,2016,143(13):2398-2409.
[97] LACANNA R,LICCARDO D,ZHANG P,et al.Yap/Taz regulate alveolar regeneration and resolution of lung inflammation[J].The Journal of Clinical Investigation,2019,129(5):2107-2122.
[98] VANYAI H K,PRIN F,GUILLERMIN O,et al.Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway[J].Development,2020,147(21):dev187187.
[99] MIA M M,CIBI D M,BINTE ABDUL GHANI S A,et al.Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodeling and improves cardiac function[J/OL].Cardiovascular Research,2021:cvab205.(2021-06-16)[2021-06-16].https://pubmed.ncbi.nlm.nih.gov/34132780.DOI:10.1093/cvr/cvab205.
[100] MIA M M,CIBI D M,ABDUL GHANI S A B,et al.YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction[J].PLoS Biology,2020,18(12):e3000941.
[101] LIU W A,CHEN S,LI Z Z,et al.PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia[J].Genes & Development,2018,32(11/12):763-780.
[102] OKUYAMA M,JIANG W H,YANG L H,et al.Mst1/2 kinases inhibitor,XMU-MP-1,attenuates angiotensin Ⅱ-induced ascending aortic expansion in hypercholesterolemic mice[J].Circulation Reports,2021,3(5):259-266.
[103] BASU D,LETTAN R,DAMODARAN K,et al.Identification,mechanism of action,and antitumor activity of a small molecule inhibitor of Hippo,TGF-β,and Wnt signaling pathways[J].Molecular Cancer Therapeutics,2014,13(6):1457-1467.
[104] TANG Y,FANG G M,GUO F H,et al.Selective inhibition of STRN3-containing PP2A phosphatase restores Hippo tumor-suppressor activity in gastric cancer[J].Cancer Cell,2020,38(1):115-128.e9.
[105] SONG J,GAO Q L,WU B W,et al.Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway[J].European Journal of Medicinal Chemistry,2020,203:112618.
[106] WANG Q,LU P,WANG T,et al.Sitagliptin affects gastric cancer cells proliferation by suppressing melanoma-associated antigen-A3 expression through yes-associated protein inactivation[J].Cancer Medicine,2020,9(11):3816-3828.
[107] ZHAO S,XU K,JIANG R,et al.Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-associated protein signaling pathway[J].Life Sciences,2020,251:117424.
[108] YE C M,WANG W Q,XIA G J,et al.A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway[J].OncoTargets and Therapy,2019,12:2259-2269.
[109] DENT P,BOOTH L,ROBERTS J L,et al.Neratinib inhibits Hippo/YAP signaling,reduces mutant K-RAS expression,and kills pancreatic and blood cancer cells[J].Oncogene,2019,38(30):5890-5904.
[110] DONG W H,DONG Q,DING H R.Ophiopogonin B induces reactive oxygen species dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma[J].Molecular Medicine Reports,2021,24(1):534.
[111] CHAI Y T,XIANG K,WU Y Z,et al.Cucurbitacin B inhibits the Hippo-YAP signaling pathway and exerts anticancer activity in colorectal cancer cells[J].Medical Science Monitor,2018,24:9251-9258.
[112] LIU J,LI J,CHEN H,et al.Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway[J].Journal of Cellular and Molecular Medicine,2020,24(10):5786-5796.
[113] WANG H N,WANG R,HUANG D,et al.Homoharringtonine exerts anti-tumor effects in hepatocellular carcinoma through activation of the Hippo pathway[J].Frontiers in Pharmacology,2021,12:592071.
[114] TAN S J,ZHAO Z,QIAO Y N,et al.Activation of the tumor suppressive Hippo pathway by triptonide as a new strategy to potently inhibit aggressive melanoma cell metastasis[J].Biochemical Pharmacology,2021,185:114423.
[115] TAO L C,CHEN X,ZHENG Y F,et al.Chinese propolis suppressed pancreatic cancer Panc-1 cells proliferation and migration via Hippo-YAP pathway[J].Molecules,2021,26(9):2803.
[116] WANG W S,HUANG Q J,CHEN Y,et al.The novel FAT4 activator jujuboside A suppresses NSCLC tumorigenesis by activating HIPPO signaling and inhibiting YAP nuclear translocation[J].Pharmacological Research,2021,170:105723.
[117] JIAO T Y,YAO X P,ZHAO Y Y,et al.Dexamethasone-induced liver enlargement is related to PXR/YAP activation and lipid accumulation but not hepatocyte proliferation[J].Drug Metabolism and Disposition,2020,48(9):830-839.
[118] WANG C,ZHU X Y,FENG W W,et al.Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm[J].American Journal of Cancer Research,2016,6(1):27-37.
[119] LI Y J,LU J,CHEN Q,et al.Artemisinin suppresses hepatocellular carcinoma cell growth,migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling[J].Archives of Toxicology,2019,93(11):3367-3383.
[120] FU W W,ZHAO P,LI H,et al.Bazedoxifene enhances paclitaxel efficacy to suppress glioblastoma via altering Hippo/YAP pathway[J].Journal of Cancer,2020,11(3):657-667.
[121] JI X Y,SONG L H,SHENG L,et al.Cyclopeptide RA-V inhibits organ enlargement and tumorigenesis induced by YAP activation[J].Cancers,2018,10(11):449.
[122] WANG Z Y,WU Y P,WANG H F,et al.Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(1):E89-E98.
[123] LIU D D,LYU H,LIU Q,et al.Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow[J].Journal of Translational Medicine,2019,17(1):378.
[124] CHENG Y,CHEN T Y,CHEN J J.Erzhu Jiedu decoction ameliorates liver precancerous lesions in a rat model of liver cancer[J].Journal of Cancer,2020,11(24):7302-7311.
[125] SONG S M,XIE M,SCOTT A W,et al.A novel YAP1 inhibitor targets CSC-enriched radiation-resistant cells and exerts strong antitumor activity in esophageal adenocarcinoma[J].Molecular Cancer Therapeutics,2018,17(2):443-454.
[126] CHAO Y C,LEE K Y,WU S M,et al.Melatonin downregulates PD-L1 expression and modulates tumor immunity in KRAS-mutant non-small cell lung cancer[J].International Journal of Molecular Sciences,2021,22(11):5649.
[127] SAUNDERS J T,HOLMES B,BENAVIDES-SERRATO A,et al.Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastoma[J].Journal of Neuro-Oncology,2021,152(2):217-231.
[128] LORTHONGPANICH C,CHAROENWONGPAIBOON T,SUPAKUN P,et al.Fisetin inhibits osteogenic differentiation of mesenchymal stem cells via the inhibition of YAP[J].Antioxidants,2021,10(6):879.
[129] MÉLIN L,ABDULLAYEV S,FNAICHE A,et al.Development of LM98,a small-molecule TEAD inhibitor derived from flufenamic acid[J].ChemMedChem,2021,16(19):2982-3002.
[130] SMITH S A,SESSIONS R B,SHOEMARK D K,et al.Antiproliferative and antimigratory effects of a novel YAP-TEAD interaction inhibitor identified using in silico molecular docking[J].Journal of Medicinal Chemistry,2019,62(3):1291-1305.
[131] KIM S H,JIN H,MENG R Y,et al.Activating Hippo pathway via Rassf1 by ursolic acid suppresses the tumorigenesis of gastric cancer[J].International Journal of Molecular Sciences,2019,20(19):4709.
[132] XUE M L,LIANG H,JI X Q,et al.Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis[J].The Journal of Nutritional Biochemistry,2020,82:108396.
[133] ZHENG Y Z,YANG X P,TAN J,et al.Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ[J].Environmental Toxicology,2021,36(6):1135-1142.
[134] GAO Y,SHI Q,XU S,et al.Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells[J].International Journal of Molecular Sciences,2014,15(9):15173-15187.
[135] WANG Z L,XING W,SONG Y L,et al.Folic acid has a protective effect on retinal vascular endothelial cells against high glucose[J].Molecules,2018,23(9):2326.
[136] HONG L,ZHA Y J,WANG C,et al.Folic acid alleviates high glucose and fat-induced pyroptosis via inhibition of the Hippo signal pathway on H9C2 cells[J].Frontiers in Molecular Biosciences,2021,8:698698.
[137] TRUJILLO-GONZALEZ I,FRIDAY W B,MUNSON C A,et al.Low availability of choline in utero disrupts development and function of the retina[J].FASEB Journal,2019,33(8):9194-9209.
[138] WANG Z H,LI L,GU W W,et al.Resveratrol reverses osteogenic decline of bone marrow mesenchymal stem cells via upregulation of YAP expression in inflammatory environment[J].Stem Cells and Development,2021,30(24):1202-1214.
[139] KIM Y N,CHOE S R,CHO K H,et al.Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis[J].Experimental & Molecular Medicine,2017,49(2):e296.
[140] XU G R,CHEN J Z,WANG G R,et al.Resveratrol inhibits the tumorigenesis of follicular thyroid cancer via ST6GAL2-regulated activation of the Hippo signaling pathway[J].Molecular Therapy Oncolytics,2020,16:124-133.
[141] JIANG Z D,CHEN X,CHEN K,et al.YAP inhibition by resveratrol via activation of AMPK enhances the sensitivity of pancreatic cancer cells to gemcitabine[J].Nutrients,2016,8(10):546.
[142] LI C X,ZHANG R R,ZHAN Y T,et al.Resveratrol inhibits hepatic stellate cell activation via the Hippo pathway[J].Mediators of Inflammation,2021,2021:3399357.
文章导航

/