综述 REVIEW

线粒体功能调控机制进展及研究方法

  • 肖昊 ,
  • 蒋宗勇 ,
  • 王丽 ,
  • 叶秀峰
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  • 广东省农业科学院动物科学研究所, 农业部华南动物营养与饲料重点实验室, 畜禽育种国家重点实验室, 岭南现代农业科学与技术广东省实验室茂名分中心, 广东省畜禽育种与营养研究重点实验室, 广州 510640
肖昊(1988—),女,湖南长沙人,副研究员,博士,主要从事猪营养与饲料科学研究。E-mail:xiaohao@gdaas.cn

收稿日期: 2022-05-05

  网络出版日期: 2022-12-15

基金资助

国家自然科学基金项目(31902172);科技创新战略专项资金(高水平农科院建设)-优秀博士(R2017YJ-YB1004);财政部和农业农村部——国家现代农业产业技术体系;广东省农业科学院院长基金项目(201912);广东省农业科学院科技计划项目(202106TD)

Research Progress and Methods of Mitochondrial Function Regulation Mechanism

  • XIAO Hao ,
  • JIANG Zongyong ,
  • WANG Li ,
  • YE Xiufeng
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  • Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Laboratory Maoming Branch Center of Lingnan Modern Agricultural Science and Technology, State Key Laboratory of Animal Breeding, Key Laboratory of Animal Nutrition and Feed in South China, Ministry of Agriculture, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2022-05-05

  Online published: 2022-12-15

摘要

线粒体是细胞代谢的中枢,参与细胞能量供应、新陈代谢以及凋亡、免疫等机体功能,也是细胞在各种压力下的第1道防线。维持蛋白质正确的折叠和质量控制对维持线粒体功能及细胞存活具有重要意义。因此,本文对线粒体功能损伤的调控机制(主要阐述线粒体自噬和线粒体未折叠蛋白反应)的研究进展和线粒体功能研究方法等方面进行了综述,旨在为进一步促进以线粒体为靶标的营养调控剂在动物生产上的应用提供参考。

本文引用格式

肖昊 , 蒋宗勇 , 王丽 , 叶秀峰 . 线粒体功能调控机制进展及研究方法[J]. 动物营养学报, 2022 , 34(12) : 7481 -7488 . DOI: 10.3969/j.issn.1006-267x.2022.12.001

Abstract

Mitochondria are the center of cell metabolism, including cell energy metabolism, cell apoptosis, immunity and so on. Mitochondria are also the first line of defense for cells under various pressures. Therefore, correct protein folding and quality control are important for maintaining mitochondrial function and cell survival. Here, the paper reviews the mechanisms of mitochondrial function damage (mainly focusing on mitochondrial autophagy and mitochondrial unfolded protein response) and the research methods of mitochondrial function. It provides a theoretical basis for promoting the application of mitochondria-targeted nutritional regulators in animal production.

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