综述 REVIEW

噬菌体制剂在家禽生产中的应用及安全性评价

  • 王君雁 ,
  • 范秋丽 ,
  • 兰瑞霞 ,
  • 蒋守群
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  • 1. 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 农业农村部华南动物营养与饲料重点实验室, 广东省畜禽育种与营养研究重点实验室, 广州 510640;
    2. 广东海洋大学, 湛江 524088
王君雁(1999—),女,甘肃武威人,硕士研究生,从事动物营养调控研究。E-mail:1034449749@qq.com

收稿日期: 2022-05-20

  网络出版日期: 2022-12-15

基金资助

国家自然科学基金青年科学基金项目(31802104);广东省自然科学基金面上项目(2021A1515010830)

Application and Safety Evaluation of Bacteriophage Preparation in Poultry Production

  • WANG Junyan ,
  • FAN Qiuli ,
  • LAN Ruixia ,
  • JIANG Shouqun
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  • 1. Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agricultural and Rural Affairs, State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. Guangdong Ocean University, Zhanjiang 524088, China

Received date: 2022-05-20

  Online published: 2022-12-15

摘要

由于抗生素滥用出现的药物残留,且使用抗生素易导致细菌的多重耐药性,因此抗生素已被禁止在畜禽饲粮中使用。近年来,抗生素替代品成为畜禽业研究的热点,目前常用的抗生素替代品包括微生态制剂、噬菌体制剂、植物提取物以及中草药制剂等。噬菌体是一种核酸病毒,研究表明,噬菌体能提高动物的生产性能和免疫功能,调节肠道菌群结构等。但噬菌体制剂容易造成体内的内毒素沉积,因此噬菌体的使用剂量以及安全性需要进一步探讨。本文综述了噬菌体的特性与来源、在家禽生产中的应用及调控机制,阐述了噬菌体制剂开发和安全性评价方面的研究进展,旨在为噬菌体制剂作为替抗添加剂在家禽生产中的科学合理应用提供参考。

本文引用格式

王君雁 , 范秋丽 , 兰瑞霞 , 蒋守群 . 噬菌体制剂在家禽生产中的应用及安全性评价[J]. 动物营养学报, 2022 , 34(12) : 7555 -7563 . DOI: 10.3969/j.issn.1006-267x.2022.12.009

Abstract

Because of the problem of drug residues caused by the abuse of antibiotics and the tendency to lead to multiple drug resistance of bacteria, the use of antibiotics in poultry diets has been banned. In recent years, antibiotic substitutes have become a research and development hot spot in livestock and poultry industry. Currently, the commonly used antibiotic substitutes include probiotics, bacteriophage preparations and Chinese herbal preparations. Bacteriophage is a nucleic acid virus, which can regulate intestinal flora structure, improve animal performance, immune function and so on. However, the bacteriophage preparation is easy to cause endotoxin deposition in the body, so the dosage and safety of bacteriophage need to be further discussed. This paper summarized the characteristics and sources of bacteriophage, application and mechanism in poultry production, and expounded the research progress of the development of bacteriophage preparation and its safety evaluation, aiming to provide references for the scientific and rational application of bacteriophage preparation as a substitute to antibiotic additive in poultry production.

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