本试验旨在研究脂多糖（LPS）刺激所产生的免疫应激对仔鹅早期生长发育的影响及L-精氨酸对免疫应激的缓解作用。选取128只14日龄健康扬州鹅公鹅，随机分为A、B、C、D 4个组，每组4个重复，每个重复8只鹅。A组饲喂基础饲粮，并静脉注射生理盐水；B组饲喂基础饲粮，并注射细菌LPS；C组饲喂添加0.5%L-精氨酸的基础饲粮，并注射LPS；D组饲喂添加1.0%L-精氨酸的基础饲粮，并注射LPS。14日龄逐一称重，并分别于15、17、19日龄进行注射，21日龄时屠宰采样，称量试验鹅活重以及心脏、肝脏、肌胃、脾脏、胸腺、腔上囊的重量。结果表明：1）LPS刺激导致3周龄仔鹅体增重显著下降（P<0.05），而0.5%精氨酸可在一定程度上缓解LPS刺激导致的3周龄仔鹅体增重的下降（P>0.05）；2）LPS刺激导致3周龄仔鹅腔上囊重量显著降低（P<0.05），而0.5%精氨酸可在一定程度上缓解LPS刺激导致的腔上囊重量的降低（P>0.05）；LPS刺激导致3周龄仔鹅腔上囊指数显著降低（P<0.05）；0.5%或1.0%精氨酸使LPS刺激3周龄仔鹅的脾脏指数显著增加（P<0.05）；3）LPS刺激导致3周龄仔鹅肠道长度显著减小（P<0.05），而0.5%精氨酸可在一定程度上缓解LPS刺激导致的肠道长度的减小（P>0.05）。本试验以仔鹅生长发育为衡量指标，表明适当的精氨酸添加量可以缓解鹅由LPS刺激所产生的免疫应激。

The experiment was conducted to study the effects of dietary L-arginine (Arg) concentration on growth performance and visceral development in male lipopolysaccharide (LPS) challenged goslings. One hundred and twenty-eight 14-day-old male Yangzhou goslings were randomly assigned to 4 groups, and each group had 4 replicates with 8 goslings per replicate. The four groups included A) nonchallenged group, B) challenged group, C) 0.5% Arg group and D) 1.0% Arg group. At 14-day-old, the goslings were weighed one by one. At 15, 17 and 19 days of age, goslings in groups B, C and D were injected with 0.5 mg/kg BW LPS, whereas goslings in group A were injected with an equivalent amount of sterile physiological saline solution. At 21-day-old, the goslings were weighed again and slaughtered to determine the weight of heart, liver, gizzard, spleen, thymus and bursa of Fabricius. The results showed as follows: 1) LPS reduced the daily weight gain in 3 weeks old goslings (P<0.05), and 0.5% Arg alleviated the decrease induced by LPS to some extent (P>0.05); 2) LPS reduced the weight of bursa of Fabricius in 3 weeks old goslings (P<0.05), and 0.5% Arg alleviated the decrease of the weight of bursa of Fabricius induced by LPS to some extent (P>0.05); LPS reduced bursa of Fabricius index of 3 weeks old goslings (P<0.05), 0.5% or 1.0% Arg increased the spleen index after LPS challenge (P<0.05); 3) LPS reduced the length of intestinal tract of 3 weeks old goslings (P<0.05), and 0.5% Arg alleviated the decrease of the length of intestinal tract induced by LPS to some extent (P>0.05). By measuring the growth and development of goslings, it indicated that L-arginine could alleviate the stress response of goslings induced by LPS to some degree.［Chinese Journal of Animal Nutrition, 2010，22（4）:1071-1075］