本研究旨在探讨高浓度硫酸锌对仔猪肝脏脂肪代谢的影响。试验选用120头平均始重为（26.66±2.45） kg的“杜×长×大”三元杂交仔猪，随机分成4组（对照组、试验组Ⅰ、试验组Ⅱ和试验组Ⅲ），每组3个重复，每个重复10头猪，分别饲喂添加60、300、1 000和3 000 mg/kg锌的基础饲粮。预试期7 d，正试期16 d。结果表明，与对照组相比，1)各试验组血清总甘油三酯和低密度脂蛋白胆固醇含量均显著提高(P<0.05)；2)试验组Ⅲ血清总胆固醇、C18︰1脂肪酸含量显著升高(P<0.05)，肝脏C18︰0、C18︰2脂肪酸含量显著降低(P<0.05)，而C16︰0脂肪酸含量无显著变化(P>0.05)；3)试验组Ⅱ和试验组Ⅲ肝脏硬脂酰辅酶A去饱和酶1（SCD1）mRNA水平、血浆瘦素和胰岛素含量都显著升高(P<0.05)。随着锌浓度的升高，血浆四碘甲状腺原氨酸（T4）含量显著降低(P<0.05)，三碘甲状腺素原氨酸(T3)和胰高血糖素含量有上升趋势，但差异不显著(P>0.05)。由此可知，饲粮中添加1 000和3 000 mg/kg锌上调了仔猪肝脏SCD1转录水平，促进了机体饱和脂肪酸（C18︰0）的去饱和化，增加了机体甘油三酯和胆固醇的合成，且高锌可通过促进瘦素和胰岛素的分泌调节机体的脂肪代谢。

The present study was conducted to investigate the effects of high dietary zinc levels on hepatic lipid metabolism in piglets. One hundred and twenty cross-bred (Duroc×Landrace×Yorkshine) piglets with initial body weight of (26.66±2.45) kg were randomly allocated into 4 groups (control group, trial groups Ⅰ, Ⅱ and Ⅲ) with 3 replicates in each group and 10 piglets in each replicate. Pigs were fed corn-soybean meal-based diets supplemented with 60, 300, 1 000 and 3 000 mg/kg Zn, respectively. The trial lasted for 16 days after a 7-day adaptation period. The results showed as follows: compared with the control group, 1) total triglycerids and low density lipoprotein cholesterol (LDL-C) in serum were significantly increased in all dietary treatment groups(P<0.05); 2) in trial group Ⅲ, serum cholesterol and oleate (C18︰1) levels were significantly increased (P<0.05), and the concentrations of stearate (C18︰0) and octadecadienoic acid (C18︰2) were significantly decreased (P<0.05), but the concentration of palmitate (16︰0) was unaffected (P>0.05); 3) in trial groups Ⅱ and Ⅲ, the levels of stearoyl CoA desaturease (SCD1) mRNA, plasma leptin and insulin were significantly increased (P<0.05), the level of T4 in plasma was significantly decreased (P<0.05), and increasing trends are shown in the levels of T3 and glucagon, but no significant differences were observed (P>0.05). The results indicate that high level of zinc up-regulate the transcription level of SCD1, and enhance the desaturation of C18︰0 and synthesis of triglycerid as well as cholesterol. Moreover, high level of zinc can regulate the metabolism of hepatic fatty acids by stimulating the secreation of leptin and insulin.［Chinese Journal of Animal Nutrition, 2010，22（5）:1200-1206］