Research Advances on High Dosage Dietary Zinc Oxide and Alternatives in Weaned Piglets
ZHANG Yanli, JIANG Xianren, LI Xilong
Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Abstract:High dosage dietary zinc oxide can alleviate diarrhea, promote growth and improve immunity in weaned piglet. However, the abuse of zinc oxide led to a series of problems, such as environmental pollution, bacterial resistance, zinc poisoning and so on. Therefore, it is urgent to find a green and effective substitute for high-dose zinc oxide. In this review, the practical application and underlying mechanism of high-dose zinc oxide in weaned piglets and the research advances of some zinc oxide substitutes were reviewed, hoping to provide theoretical basis for finding the most suitable alternative to replace high-dose zinc oxide.
张彦利, 蒋显仁, 李习龙. 饲粮高剂量氧化锌及其替代物在断奶仔猪中的研究进展[J]. 动物营养学报, 2021, 33(3): 1257-1265.
ZHANG Yanli, JIANG Xianren, LI Xilong. Research Advances on High Dosage Dietary Zinc Oxide and Alternatives in Weaned Piglets. Chinese Journal of Animal Nutrition, 2021, 33(3): 1257-1265.
何学谦.高锌使用时间长短对早期断奶仔猪后期生长性能及腹泻率的影响[J].饲料工业,2010,31(17):35-37. HE X Q.Influence of using time of high zinc on growing performance and diarrhea rate for weanling pig[J].Feed Industry,2010,31(17):35-37.(in Chinese)
[48]
HUANG K L,LEE Y H,CHEN H I,et al.Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice[J].Journal of Hazardous Materials,2015,297:304-312.
[3]
冷静,戴志明,杨国明,等.高剂量锌及抗生素对预防断奶仔猪腹泻和促生长的影响[J].中国兽医科技,2003,33(12):62-64. LENG J,DAI Z M,YANG G M,et al.Effect of high level zinc in diet upon diarrhea and growth performance in weanling pigs[J].Chinese Journal of Veterinary Science and Technology, 2003,33(12):62-64.(in Chinese)
[5]
SMITH Ⅱ J W,TOKACH M D,GOODBAND R D,et al.Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs[J].Journal of Animal Science,1997,75(7):1861-1866.
[1]
POULSEN H H D.Zinc oxide for weaned pigs[C]//40th Annual Meeting of the European Association for Animal Production.Dublin:EAAP Publications,1989:265-266.
[7]
SHELTON N W,TOKACH M D,NELSSEN J L,et al.Effects of copper sulfate,tri-basic copper chloride,and zinc oxide on weanling pig performance[J].Journal of Animal Science,2011,89(8):2440-2451.
[11]
王勇,钮海华,马文强,等.甘氨酸锌对断奶仔猪生长性能、免疫指标及肠道形态的影响[J].动物营养学报,2010,22(1):176-180. WANG Y,NIU H H,MA W Q,et al.Effects of dietary zinc glycine chelate on growth performance,immunological parameters and intestinal morphology in weanling piglets[J].Chinese Journal of Animal Nutrition,2010,22(1):176-180.(in Chinese)
[14]
KLOUBERT V,BLAABJERG K,DALGAARD T S,et al.Influence of zinc supplementation on immune parameters in weaned pigs[J].Journal of Trace Elements in Medicine and Biology,2018,49:231-240.
[2]
郑家茂,赵国芬,许梓荣.氧化锌和硫酸锌对仔猪断奶后腹泻率和生长的影响[J].饲料工业,2000,21(7):11-12. ZHENG J M,ZHAO G F,XU Z R.Effect of zinc oxide and zinc sulphate on growth performance and diarrhea incidence in the weanling pigs[J].Feed Industry,2000,21(7):11-12.(in Chinese)
[6]
DAVIS M E,BROWN D C,MAXWELL C V,et al.Effect of phosphorylated mannans and pharmacological additions of zinc oxide on growth and immunocompetence of weanling pigs[J].Journal of Animal Science,2004,82(2):581-587.
[8]
LI X L,YIN J D,LI D F,et al.Dietary supplementation with zinc oxide increases IGF-Ⅰ and IGF-Ⅰ receptor gene expression in the small intestine of weanling piglets[J].The Journal of Nutrition,2006,136(7):1786-1791.
[9]
MARTIN L,PIEPER R,SCHUNTER N,et al.Performance,organ zinc concentration,jejunal brush border membrane enzyme activities and mRNA expression in piglets fed with different levels of dietary zinc[J].Archives of Animal Nutrition,2013,67(3):248-261.
[10]
唐萍.锌源和锌水平对断奶应激仔猪免疫机能的影响[D].硕士学位论文.合肥:安徽农业大学,2006. TANG P.Effect of zinc resources and levels on immune function of weanling stress piglets[J].Master's Thesis.Hefei:Anhui Agricultural University,2006.(in Chinese)
[12]
BERGERON N,ROBERT C,GUAY F.Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets[J].Animal Nutrition,2017,3(3):236-246.
[13]
JANCZYK P,KREUZER S,ASSMUS J,et al.No protective effects of high-dosage dietary zinc oxide on weaned pigs infected with Salmonella enterica serovar typhimurium DT104[J].Applied and Environmental Microbiology,2013,79(9):2914-2921.
[15]
YIN J D,LI X L,LI D F,et al.Dietary supplementation with zinc oxide stimulates ghrelin secretion from the stomach of young pigs[J].Journal of Nutritional Biochemistry,2009,20(10):783-790.
[16]
PIEPER R,MARTIN L,SCHUNTER N,et al.Impact of high dietary zinc on zinc accumulation,enzyme activity and proteomic profiles in the pancreas of piglets[J].Journal of Trace Elements in Medicine and Biology,2015,30:30-36.
[18]
ZHANG B K,GUO Y M.Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1(ZO-1) expression in weaning piglets[J].British Journal of Nutrition,2009,102(5):687-693.
[17]
LI M Z,HUANG J T,TSAI Y H,et al.Nanosize of zinc oxide and the effects on zinc digestibility,growth performances,immune response and serum parameters of weanling piglets[J].Animal Science Journal,2016,87(11):1379-1385.
[19]
WANG W,VAN NOTEN N,DEGROOTE J,et al.Effect of zinc oxide sources and dosages on gut microbiota and integrity of weaned piglets[J].Journal of Animal Physiology and Animal Nutrition,2019,103(1):231-241.
[20]
VAHJEN W,PIEPER R,ZENTEK J.Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets[J].Journal of Animal Science,2011,89(8):2430-2439.
[22]
LIU P,PIEPER R,RIEGER J,et al.Effect of dietary zinc oxide on morphological characteristics,mucin composition and gene expression in the colon of weaned piglets[J].PLoS One,2014,9(3):e91091.
OU D Y,LI D F,CAO Y L,et al.Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs[J].The Journal of Nutritional Biochemistry,2007,18(12):820-826.
[26]
JONDREVILLE C,REVY P S,DOURMAD J Y.Dietary means to better control the environmental impact of copper and zinc by pigs from weaning to slaughter[J].Livestock Production Science,2003,84(2):147-156.
[30]
WALK C L,WILCOCK P,MAGOWAN E.Evaluation of the effects of pharmacological zinc oxide and phosphorus source on weaned piglet growth performance,plasma minerals and mineral digestibility[J].Animal,2015,9(7):1145-1152.
[34]
SLIFIERZ M J,FRIENDSHIP R,WEESE J S.Zinc oxide therapy increases prevalence and persistence of methicillin-resistant Staphylococcus aureus in pigs:a randomized controlled trial[J].Zoonoses and Public Health,2015,62(4):301-308.
[36]
陈亮.高锌日粮长期暴露对断奶仔猪影响的免疫病理学研究[D].硕士学位论文.合肥:安徽农业大学,2008. CHEN L.Study of immune pathology of high zinc diet long-term exposure on effects of weanling piglets[D].Master's Thesis.Hefei:Anhui Agricultural University,2008.(in Chinese)
[21]
SARGEANT H R,MCDOWALL K J,MILLER H M,et al.Dietary zinc oxide affects the expression of genes associated with inflammation:transcriptome analysis in piglets challenged with ETEC K88[J].Veterinary Immunology and Immunopathology,2010,137(1/2):120-129.
[25]
CASE C L,CARLSON M S.Effect of feeding organic and inorganic sources of additional zinc on growth performance and zinc balance in nursery pigs[J].Journal of Animal Science,2002,80(7):1917-1924.
[28]
杨怀兵,李辉,黄建国,等.高锌在断奶仔猪日粮中的应用效果研究概述[J].中国畜牧兽医,2013,40(12):220-223. YANG H B,LI H,HUANG J G,et al.Research review of dietary high zinc on weaning piglets[J].China Animal Husbandry & Veterinary Medicine,2013,40(12):220-223.(in Chinese)
[29]
辜玉红,童晓莉,钟正泽.日粮高锌对仔猪养分消化率血液生理生化指标及粪中锌含量的影响研究[J].当代畜牧,2004(2):32-34. GU Y H,TONG X L,ZHONG Z Z.Effects of dietary high zinc on nutrient digestibility,blood physiological and biochemical indices and zinc content in feces of piglets[J].Contemporary Animal Husbandry,2004(2):32-34.(in Chinese)
[32]
VAHJEN W,PIETRUSZYŃSKA D,STARKE I C,et al.High dietary zinc supplementation increases the occurrence of tetracycline and sulfonamide resistance genes in the intestine of weaned pigs[J].Gut Pathogens,2015,7:23.
[33]
CIESINSKI L,GUENTHER S,PIEPER R,et al.High dietary zinc feeding promotes persistence of multi-resistant E. coli in the swine gut[J].PLoS One,2018,13(1):e0191660.
[35]
王希春,吴金节,陈亮,等.高锌日粮对断奶仔猪肠道黏膜免疫及黏膜上皮形态的影响[J].中国兽医学报,2010,30(10):1371-1376. WANG X C,WU J J,CHEN L,et al.Effect of high-level zinc diets on intestinal mucosal immunity and morphology of weanling piglets[J].Chinese Journal of Veterinary Science,2010,30(10):1371-1376.(in Chinese)
[38]
JANCZYK P,BÜSING K,DOBENECKER B,et al.Effect of high dietary zinc oxide on the caecal and faecal short-chain fatty acids and tissue zinc and copper concentration in pigs is reversible after withdrawal of the high zinc oxide from the diet[J].Journal of Animal Physiology and Animal Nutrition,2015,99(Suppl.1):13-22.
[39]
SCHULTE J N,BROCKMANN G A,KREUZER-REDMER S.Feeding a high dosage of zinc oxide affects suppressor of cytokine gene expression in Salmonella typhimurium infected piglets[J].Veterinary Immunology and Immunopathology,2016,178:10-13.
[42]
SHARMA V,SINGH S K,ANDERSON D,et al.Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes[J].Journal of Nanoscience and Nanotechnology,2011,11(5):3782-3788.
[43]
张金波,宋汉君,周子靖,等.纳米二氧化硅和纳米氧化锌颗粒对人肝癌细胞的毒性作用[J].环境与健康杂志,2017,34(4):317-320. ZHANG J B,SONG H J,ZHOU Z J,et al.Toxic effect of nano-silicon dioxide and nano-zinc oxide particles on HepG2 cells[J].Journal of Environment and Health,2017,34(4):317-320.(in Chinese)
[45]
吴诚,文利新,袁慧,等.纳米氧化锌对小鼠的毒性试验[J].粮食与饲料工业,2008(5):38-39. WU C,WEN L X,YUAN H,et al.Toxicity experiment of nano-zinc oxide on mice[J].Cereal & Feed Industry,2008(5):38-39.(in Chinese)
[49]
HACKENBERG S,SCHERZED A,TECHNAU A,et al.Cytotoxic,genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro[J].Toxicology in Vitro,2011,25(3):657-663.
[27]
MEYER T A,LINDEMANN M D,CROMWELL G L,et al.Effects of pharmacological levels of zinc as zinc oxide on fecal zinc and mineral excretion in weanling pigs[J].The Professional Animal Scientist,2002,18(2):162-168.
[40]
PEI X,XIAO Z P,LIU L J,et al.Effects of dietary zinc oxide nanoparticles supplementation on growth performance,zinc status,intestinal morphology,microflora population,and immune response in weaned pigs[J].Journal of the Science of Food and Agriculture,2019,99(3):1366-1374.
[44]
SHARMA V,SINGH P,PANDEY A K,et al.Induction of oxidative stress,DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles[J].Mutation Research/Genetic Toxicology and Environmental Mutagenesis,2012,745(1/2):84-91.
[46]
洪丽玲,张天宝.3种粒径纳米氧化锌与常规氧化锌对大鼠的亚慢性毒性[J].癌变·畸变·突变,2018,30(1):52-57. HONG L L,ZHANG T B.Sub-chronic toxicity of three scales of nano- and micron-zinc oxide in rats[J].Carcinogenesis,Teratogenesis & Mutagenesis,2018,30(1):52-57.(in Chinese)
[50]
刘连龙,李浙烽,陈强,等.包膜氧化锌体外稳定性试验及其对断奶仔猪生长性能的影响[J].中国畜牧杂志,2011,47(23):54-58. LIU L L,LI Z F,CHEN Q,et al.In vitro stability experiment of coated zinc oxide and its effect on growth performance of weaned piglets[J].Chinese Journal of Animal Science,2011,47(23):54-58.(in Chinese)
[52]
BAI M M,LIU H N,XU K,et al.Use of coated nano zinc oxide as an additive to improve the zinc excretion and intestinal morphology of growing pigs[J].Journal of Animal Science,2019,97(4):1772-1783.
[54]
BYUN Y J,LEE C Y,KIM M H,et al.Effects of dietary supplementation of a lipid-coated zinc oxide product on the fecal consistency,growth,and morphology of the intestinal mucosa of weanling pigs[J].Journal of Animal Science and Technology,2017,59:29.
[56]
LONG L,CHEN J S,ZHANG Y G,et al.Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets[J].PLoS One,2017,12(8):e0182550.
[58]
李小强,马红艳,李辉,等.多孔氧化锌对断奶仔猪生长性能、绒毛形态及肠道微生物菌群的影响[J].中国饲料,2020(8):76-79. LI X Q,MA H Y,LI H,et al.Effects of porous zinc oxide on growth performance,villi morphology and intestinal microflora of weaned piglets[J].China Feed,2020(8):76-79.(in Chinese)
[59]
ROMÉO A,VAN NOTEN N,DEGROOTE J,et al.Effet de deux sources d'oxyde de zinc sur différents paramètres de la muqueuse intestinale de porcelets[J].Journées de la Recherche Porcine en France,2018,50:151-152.
[60]
PENG P,CHEN J S,YAO K,et al.The effects of dietary supplementation with porous zinc oxide on growth performance,intestinal microbiota,morphology,and permeability in weaned piglets[J].Animal Science Journal,2019,90(9):1220-1228.
[31]
BEDNORZ C,OELGESCHLÄGER K,KINNEMANN B,et al.The broader context of antibiotic resistance:zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo[J].International Journal of Medical Microbiology,2013,303(6/7):396-403.
[37]
STARKE I C,PIEPER R,NEUMANN K,et al.The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets[J].FEMS Microbiology Ecology,2014,87(2):416-427.
[41]
XIA T,LAI W Q,HAN M M,et al.Dietary ZnO nanoparticles alters intestinal microbiota and inflammation response in weaned piglets[J].Oncotarget,2017,8(39):64878-64891.
[47]
WANG B,FENG W Y,WANG M,et al.Acute toxicological impact of nano-and submicro-scaled zinc oxide powder on healthy adult mice[J].Journal of Nanoparticle Research,2008,10(2):263-276.
[51]
SHEN J H,CHEN Y,WANG Z S,et al.Coated zinc oxide improves intestinal immunity function and regulates microbiota composition in weaned piglets[J].British Journal of Nutrition,2014,111(12):2123-2134.
[57]
MORALES J,CORDERO G,PIÑEIRO C,et al.Zinc oxide at low supplementation level improves productive performance and health status of piglets[J].Journal of Animal Science,2012,90(Suppl.4):436-438.
[53]
SONG Y M,KIM M H,KIM H N,et al.Effects of dietary supplementation of lipid-coated zinc oxide on intestinal mucosal morphology and expression of the genes associated with growth and immune function in weanling pigs[J].Asian-Australasian Journal of Animal Sciences,2017,31(3):403-409.
[55]
VAHJEN W,ZENTEK J,DUROSOY S.Inhibitory action of two zinc oxide sources on the ex vivo growth of porcine small intestine bacteria[J].Journal of Animal Science,2012,90(Suppl.4):334-336.