本试验旨在考察高锌(Zn)和高铜(Cu)对断奶仔猪生产性能、消化生理和盲肠微生物数量的影响。选取105头(25±1)日龄断奶的D×L×Y仔猪，随机分为3个组，每个组5个重复，每个重复7头仔猪，分别饲喂基础日粮、基础日粮+2 500 mg/kg锌(氧化锌)和基础日粮+250 mg/kg铜(硫酸铜)。试验期28 d。于试验的第3周末时，每个重复选1头仔猪屠宰，考察消化道消化酶活性和盲肠微生物数量。结果表明，日粮添加高锌和高铜使仔猪全期(1～4周)平均日增重(ADG)分别提高19.92%(P<0.05)和23.24%(P<0.01)，料重比(F/G)分别降低6.67%(P>0.05)和12.78%(P<0.01)。高锌和高铜均能使Ca和P的消化率提高(P<0.01或P<0.05)。高锌和高铜均能提高仔猪胃蛋白酶和胰淀粉酶活性(P<0.05)，改善回肠、空肠和十二指肠绒毛高度及3肠段绒毛高度与隐窝深度之比，其中回肠绒毛高度/隐窝深度显著增加(P<0.05)，且高铜组空肠绒毛高度/隐窝深度显著高于对照组(P<0.05)和高锌组(P<0.05)。高锌和高铜有降低盲肠大肠杆菌、乳酸杆菌和双歧杆菌数量的趋势，但差异不显著(P>0.05)。综合来看，高铜高锌能改善断奶仔猪生产性能、养分消化率及消化酶活性，且高铜促生长效应优于高锌。

This experiment was conducted to investigate the effects of high levels of dietary zinc and copper on growth performance, digestive physiology and cecal microbe of weanling piglets. One hundred and five weanling D×L×Y piglets at (25±1)-day-old were randomly allocated to 3 treatments with 5 replicates of 7 piglets per replicate. The pigs were fed basal diet, and basal diet supplemented with zinc (2 500 mg/kg) and copper (250 mg/kg) respectively for a 28-d experimental period. At the end of 3rd week, one piglet of each replicate was chosen to slaughter and to investigate the digestive enzyme activities and cecal microbe. The results showed that adding high levels of zinc and copper significantly increased ADG by 19.92% (P<0.05) and 23.24% (P<0.01), decreased the F/G by 6.67% (P>0.05) and 12.78% (P<0.01), respectively. Adding high levels of zinc and copper significantly improved digestibilities of Ca and P (P<0.05 and P<0.01). Pepsin activities and amylopsin activities were significantly increased in piglets fed diets supplemented with 2 500 mg/kg zinc or 250 mg/kg copper (P<0.05). Piglets fed high levels of zinc or copper had the tendency to improve villous length and the ratio of villous length to crypt depth (VCR) of jejunum, ileum and duodenum; the VCR of ileum was significantly increased (P<0.05); and the VCR of jejunum in high copper group significantly higher than that in control group and high zinc group (P<0.05). The amount of E.coli, Lactobacillus and Bifidobacteria in cecum tended to reduce in piglets fed diets with high levels of zinc or copper (P>0.05). In summary, high levels of dietary zinc or copper could increase growth performance, digestibilities of nutrient and activities of digestive enzymes; diet supplemented with high level of copper had better growth-improving effect than diet supplemented with high level of zinc in weanling piglets.［Chinese Journal of Animal Nutrition, 2009，21(6):903-909］