CCS is the copper chaperone for copper/zinc-superoxide dismutase 1 (SOD1) in cytoplasm. This review described the activation process of cytosolic SOD1 mediated by CCS. With the protein-protein interaction of CCS and SOD1, CCS can directly insert the copper ion into apoSOD1 and promote the formation of intramolecular disulfide bond in SOD1, then finish the activation of SOD1. The activity of CCS can be affected by X-linked inhibitor of apoptosis protein (XIAP), neuronal adaptor protein X11α and copper metabolism (Murr1) domain containing 1 (COMMD1).［Chinese Journal of Animal Nutrition, 2011, 23（8）：1259 -1263］
Key words：
CCS; copper; SOD1
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