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动物食欲调节的中枢信号通路

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  • 山东农业大学动物科技学院,泰安 271018
刘 磊(1985—),男,山东青州人,硕士研究生,从事动物营养研究。E-mail: liusanshi1985@126.com

收稿日期: 2011-06-10

  网络出版日期: 2012-02-07

基金资助

国家自然科学基金(31072045);公益性行业(农业)科研专项(201003011)

Central Appetite-Regulating Signaling Pathways in Animals

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  • College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271018, China

Received date: 2011-06-10

  Online published: 2012-02-07

摘要

下丘脑是动物食欲调节的中枢,外周食欲信号在下丘脑中经食欲调节网络整合,产生饱感或饥饿。其中,以5'-磷酸腺苷激活的蛋白激酶(AMPK)调控位点上的AMPK-ACC-CPT1和UCP2-FOXO1-pCREB信号通路以及雷帕霉素靶蛋白(mTOR)调控位点上的PI3K-Akt-mTOR和mTOR-4EBP1/p70S6K-NPY/AgRP信号通路尤为重要。AMPK和mTOR在AMPK-TSC-mTOR通路、固醇类调节因子绑定蛋白(SREBP)基因表达和吞噬启动激酶(Ulk1)活性通路上存在互作。外周营养和能量信号传输到下丘脑后,经过这些网络的传输和分析,作用于下丘脑中的食欲相关肽,最终调控动物的采食行为。

关键词: 下丘脑; 食欲; 调节通路

本文引用格式

刘磊, 宋志刚 . 动物食欲调节的中枢信号通路[J]. 动物营养学报, 2012 , 24(2) : 226 -231 . DOI: 10.3969/j.issn.1006-267x.2012.02.006

Abstract

Hypothalamus is the center of appetite regulation in animals, which integrates the peripheral and central signals to generate satiety or hunger. 5'-AMP-activated protein kinase(AMPK) and mammalian target of rapamycin (mTOR) are the signals found recently in the network of food or feed intake regulation in the hypothalamus. The pathways of AMPK-ACC-CPT1, UCP2-FOXO1-pCREB, PI3K-Akt-mTOR and mTOR-4EBP1/p70S6K-NPY/AgRP are the most important ones. AMPK and mTOR might cross talk in the way of AMPK-TSC-mTOR, the gene expression of sterol regulatory element-binding proteins (SREBP) and the activity of UNC-51-like kinase (Ulk1). These signaling pathways respond to the signal transmission of nutrients and hormones to the hypothalamus, and regulate the expression of the anorexic or orexigenic peptides, and finally regulate the animal appetite.

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