综述 Review

胃肠营养化学感应及其生理效应

  • 谭碧娥 ,
  • 印遇龙
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  • 中国科学院亚热带农业生态研究所,中国科学院亚热带农业生态过程重点实验室,湖南省畜禽健康养殖工程技术中心,农业部中南动物营养与饲料科学观测实验站,长沙 410125

收稿日期: 2012-08-17

  网络出版日期: 2013-01-22

基金资助

国家自然科学基金(31001016、31110103909);中国科学院院长奖获得者科研启动专项资金资助项目

Gut Nutrient Chemosensing and Its Physiology Effects

  • TAN Bi'e ,
  • YIN Yulong
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  • Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

Received date: 2012-08-17

  Online published: 2013-01-22

摘要

胃肠化学感应(chemosensing)是指胃肠道内分泌细胞功能与内脏迷走神经元之间复杂的相互作用。胃肠道内分泌细胞监测到管腔内容物后,释放信号分子,激活神经纤维或其他靶目标,产生生理效应。本文综述了胃肠营养化学感应受体和信号转导途径,阐述了胃肠道内分泌细胞碳水化合物、蛋白质和脂肪的感应机制及其在激素分泌、摄食和黏膜防御调控中的作用。

本文引用格式

谭碧娥 , 印遇龙 . 胃肠营养化学感应及其生理效应[J]. 动物营养学报, 2013 , 25(2) : 231 -241 . DOI: 10.3969/j.issn.1006-267x.2013.02.001

Abstract

Chemosensing in the gut represents a complex interplay between the functions of enteroendocrine cells and visceral afferent neurons. Enteroendocrine cells detect the luminal contents and release signaling molecules activating nerve fibers or other targets, and then triggering a range of physiology effects. This review summarized gut nutrient sensing receptors and transduction pathways, and focused on the sensing mechanisms of carbohydrates, proteins and lipids in enteroendocrine cells and their roles in the regulations of hormone secretion, food intake and mucosal defense.

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