综述 Review

FoxO转录因子的活性调控及其对骨骼肌生长发育的调节

  • 朱宇旌 ,
  • 于治姣 ,
  • 张勇 ,
  • 李艳 ,
  • 邵彩梅
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  • 1. 沈阳农业大学畜牧兽医学院, 沈阳 110866;
    2. 辽宁禾丰牧业股份有限公司, 沈阳 110164

收稿日期: 2012-10-10

  网络出版日期: 2013-03-25

基金资助

国家自然科学基金(31101253;30972112)

Regulation of FoxO Transcription Factors Activity and Its Functions in Growth and Development of Skeletal Muscle

  • ZHU Yujing ,
  • YU Zhijiao ,
  • ZHANG Yong ,
  • LI Yan ,
  • SHAO Caimei
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  • 1. College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China;
    2. Liaoning Wellhope Agri-Tech Co., Ltd., Shenyang 110164, China

Received date: 2012-10-10

  Online published: 2013-03-25

摘要

FoxO转录因子受到各种外界刺激而被调控,主要包括胰岛素(insulin)、胰岛素样生长因子Ⅰ(IGF-Ⅰ)、营养状况、细胞因子和应激等。这些外界因素通过FoxO修饰翻译后的复杂组合来调控FoxO的亚细胞定位、DNA结合特性、蛋白质水平和转录活性,这些修饰包括磷酸化、乙酰化、泛酸化和甲基化等。现在已证明FoxO参与蛋白质的降解和合成,并且参与调节骨骼肌的生长发育。但FoxO活性调控及其信号途径在骨骼肌中具体的调控机理尚不明确。本文就FoxO的活性调控及其如何参与骨骼肌生长发育进行了综述。

本文引用格式

朱宇旌 , 于治姣 , 张勇 , 李艳 , 邵彩梅 . FoxO转录因子的活性调控及其对骨骼肌生长发育的调节[J]. 动物营养学报, 2013 , 25(4) : 677 -684 . DOI: 10.3969/j.issn.1006-267x.2013.04.002

Abstract

FoxO transcription factors are regulated by a wide range of external stimuli, including insulin, insulin-like growth factor Ⅰ (IGF-Ⅰ), nutritional status, cytokines and oxidative stress. These environmental stimuli control FoxO activity by altering an intricate combination of post-translational modifications of FoxO, such as phosphorylation, acetylation, ubiquitination and methylation, which in turn regulate subcellular localization, DNA-binding properties, protein levels and transcriptional activity. Changes in FoxO activity are somehow involved in regulation of protein degradation and/or protein synthesis, growth and development of skeletal muscle. But the regulation of FoxO activity and the regulatory mechanisms of its signaling pathways in skeletal muscle are a little known. This review summarized the regulation of FoxO activity and its functions in growth and development of skeletal muscle.

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