综述 Review

磷脂酰肌醇3-激酶/丝苏氨酸蛋白激酶信号途径及其在肌肉生长发育中的调控机制

  • 刘吉茹 ,
  • 朱宇旌 ,
  • 邵彩梅 ,
  • 张勇
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  • 1. 沈阳农业大学畜牧兽医学院, 沈阳 110866;
    2. 辽宁禾丰牧业股份有限公司, 沈阳 110164

收稿日期: 2012-10-17

  网络出版日期: 2013-03-25

基金资助

国家自然科学基金(31101253;30972112)

Phosphatidylinositol 3-Kinase/Serine-Threonine Kinase Signaling Pathway and Its Regulation Mechanisms in Muscle Growth and Development

  • LIU Jiru ,
  • ZHU Yujing ,
  • SHAO Caimei ,
  • ZHANG Yong
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  • 1. College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China;
    2. Liaoning Wellhope Agri-Tech Co., Ltd., Shenyang 110164, China

Received date: 2012-10-17

  Online published: 2013-03-25

摘要

磷脂酰肌醇3-激酶/丝苏氨酸蛋白激酶(PI3K/Akt)是一类特异性催化磷脂酰肌醇(PI)的激酶,其信号途径是细胞内重要的信号转导通路之一,广泛参与动物机体的新陈代谢过程。本文就PI3K/Akt信号途径的结构、活化机制及其在细胞凋亡和肌肉生长发育中的调控机制进行综述。

本文引用格式

刘吉茹 , 朱宇旌 , 邵彩梅 , 张勇 . 磷脂酰肌醇3-激酶/丝苏氨酸蛋白激酶信号途径及其在肌肉生长发育中的调控机制[J]. 动物营养学报, 2013 , 25(4) : 692 -698 . DOI: 10.3969/j.issn.1006-267x.2013.04.004

Abstract

Phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/Akt) is a kind of kinases which specifically catalyzes phosphatidylinositol. PI3K/Akt signaling pathway is one of the most important signaling pathways in cells and it is implicated in a broad spectrum of cell metabolism in animals. This review summarized characteristics and activation mechanism of PI3K/Akt signaling pathway, and discussed the regulation mechanisms in cell apoptosis and muscle growth and development.

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