综述 Review

牛磺酸转运体的调节机制及其在动物营养研究中的意义

  • 张小龙 ,
  • 邓欢 ,
  • 陈澄 ,
  • 张素云 ,
  • 唐志如
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  • 1. 西南大学动物科技学院, 生物饲料与分子营养实验室, 重庆 400715;
    2. 贵州大学生命科技学院, 贵阳 550025

收稿日期: 2013-04-23

  网络出版日期: 2013-09-16

基金资助

国家973重点基础研究发展计划项目(2013CB127303);重庆市自然科学基金(cstc2012jjA80001);西南大学基本科研业务费(XDJK2011C030);西南大学博士基金(SWU111002)

Taurine Transporter:Regulation Mechanism and Significance in Animal Nutrition Studies

  • ZHANG Xiaolong ,
  • DENG Huan ,
  • CHEN Cheng ,
  • ZHANG Suyun ,
  • TANG Zhiru
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  • 1. Biological Feed and Molecular Nutrition Laboratory, Southwest University, Chongqing 400715, China;
    2. College of Life Sciences, Guizhou University, Guiyang 550025, China

Received date: 2013-04-23

  Online published: 2013-09-16

摘要

牛磺酸(Tau)是可兴奋组织细胞中最丰富的游离氨基酸,具有广泛的生物学效应,主要通过细胞膜上的牛磺酸转运体(TAUT)转运入膜。TAUT受许多因素调节,如p53、sp1、c-Jun、Wilms肿瘤1基因(WT1)、渗透压反应元件(TonE)、核因子-κB(NF-κB)、抗氧化应激反应元件(ARE)、热应激因子1(HSF1)和蛋白激酶C(PKC)等。本文综述了TAUT的种类与结构、TAUT在转录与转录后水平上的调节机制及其在动物营养研究中的意义,以期为Tau在养殖业中的应用提供参考。

本文引用格式

张小龙 , 邓欢 , 陈澄 , 张素云 , 唐志如 . 牛磺酸转运体的调节机制及其在动物营养研究中的意义[J]. 动物营养学报, 2013 , 25(10) : 2222 -2230 . DOI: 10.3969/j.issn.1006-267x.2013.10.005

Abstract

Taurine (Tau) is the most abundant free amino acid with a wide range of biological effects on excitable tissue cells, and it is mainly transported by taurine transporter (TAUT) into the membrane. TAUT is regulated by many factors, such as p53, sp1, c-Jun, Wilms tumor suppressor gene 1 (WT1), tonicity-responsive element (TonE), nuclear factor-κB (NF-κB), antioxidant responsive element (ARE), heat shock transcription factor 1 (HSF1) and protein kinase C (PKC), etc. This article reviewed the TAUT's type and structure, regulation mechanism in the transcriptional and post-transcriptional level, and the study significance of regulation mechanism in animal nutrition which would be a valuable reference for the application of Tau in the breeding industry.

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