梁英 . 抗菌肽的来源及应用[J]. 动物营养学报, 2014 , 26(1) : 7 -16 . DOI: 10.3969/j.issn.1006-267x.2014.01.002

[1] HULTMARK D, STEINER H, RASMUSON T, et al.Insect immunity:purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia[J].European Journal of Biochemistry, 1980, 106(1):7-16.

[2] 韩文瑜, 孙长江.抗菌肽的研究现状与展望[J].中国兽药杂志, 2009, 43(10):11-19.

[3] BULET P, STOCKLIN R.Insect antimicrobial peptides:structures, properties and gene regulation[J].Protein & Peptide Letters, 2005, 12(1):3-11.  

[4] 王义鹏, 赖仞.昆虫抗菌肽结构、性质和基因调控[J].动物学研究, 2010, 31(1):27-34.

[5] SAMAKOVⅡS C, KYLSTEN P, KIMBRELL D A, et al.The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster[J].EMBO Journal, 1991, 10(1):163-169.

[6] BUTU M, BUTU A.Antimicrobial peptides-natural antibiotics[J].Romanian Biotechnological Letters, 2011, 16(3):6135-6145.

[7] BULET P, HETRU C, DIMARCQ J L, et al.Antimicrobial peptides in insects; structure and function[J].Developmental and Comparative Immunology, 1999, 23(4/5):329-344.

[8] BULET P, COCIANCICH S, DIMARCQ J L, et al.Insect immunity:isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family[J].Journal of Biological Chemistry, 1991, 266(36):24520-24525.

[9] CARLSSON A, ENGSTRM P, PALVA E T, et al.Attacin, an antibacterial protein from Hyalophora cecropia, inhibit synthesis of outer membrane proteins in Escherichia coli by interfering with omp gene transcription[J].Infection and Immunity, 1991, 59(9):3040-3045.

[10] IWAI H, NAKAJIMA Y, NATORI S, et al.Solution conformation of an antibacterial peptide, sarcotoxin IA, as determined by ¹H-NMR[J].European Journal of Biochemistry, 1993, 217(2):639-644.  

[11] DIMARCQ J L, KEPPI E, DUNBAR B, et al.Insect immunity:purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A[J].European Journal of Biochemistry, 1988, 171(1/2):17-22.

[12] AXÉN A, CARLSSON A, ENGSTRM A, et al.Gloverin, an antibacterial protein from the immune hemolymph of Hyalophora pupae[J].European Journal of Biochemistry, 1997, 247(2):614-619.  

[13] ⅡJIMA R, KURATA S, NATORI S.Purification, characterization, and cDNA cloning of an antifungal protein from the hemolymph of Sarcophaga peregrina (flesh fly) larvae[J].Journal of Biological Chemistry, 1993, 268(16):12055-12061.

[14] LEE S Y, MOON H J, KURATA S, et al.Purification and cDNA cloning of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae[J].Biological & Pharmaceutical Bulletin, 1995, 18(8):1049-1052.  

[15] FEHLBAUM P, BULET P, MICHAUT L, et al.Insect immunity:septic injury of drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides[J].Journal of Biological Chemistry, 1994, 269(52):33159-33163.

[16] LEVASHINA E A, OHRESSER S, BULET P, et al.Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties[J].European Journal of Biochemistry, 1995, 233(2):694-700.  

[17] FEHLBAUM P, BULET P, CHERNYSH S, et al.Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides[J].Proceedings of the National Academy of Sciences of the United States of America, 1996, 93(3):1221-1225.  

[18] STEC B.Plant thionins-the structural perspective[J].Cellular and Molecular Life Sciences, 2006, 63(12):1370-1385.  

[19] CARVALHO A O, GOMES V M.Plant defensins-prospects for the biological functions and biotechnological properties[J].Peptides, 2009, 30(5):1007-1020.  

[20] PELEGRINI P B, QUIRINO B F, FRANCO O L.Plant cyclotides:an unusual class of defense compounds[J].Peptides, 2007, 28(7):1475-1481.  

[21] KOVALSKAYA N, HAMMOND R W.Expression and functional characterization of the plant antimicrobial snakin-1 and defensin recombinant proteins[J].Protein Expression and Purification, 2009, 63(1):12-17.  

[22] GANZ T.Defensins:antimicrobial peptides of vertebrates[J].Comptes Rendus Biologies, 2004, 327(6):539-354.  

[23] DE LEEUW E, LU W Y.Human defensins:turning defense into offense?[J].Infectious Disorders-Drug Targets, 2007, 7(1):67-70.  

[24] KLVER E, ADERMANN K, SCHULZ A.Synthesis and structure-activity relationship of β-defensins, multi-functional peptides of the immune system[J].Journal of Peptide Science, 2006, 12(4):243-257.  

[25] 谢锋, 叶昌媛, 费梁, 等.中国东北地区林蛙属物种的分类学研究(两栖纲:蛙科)[J].动物分类学报, 1999, 24(2):225-231.

[26] 金莉莉, 王秋雨.蛙科两栖动物皮肤抗菌肽的分子多样性及功能[J].遗传, 2008, 30(10):1241-1248.

[27] NOGA E J, ARROLL T A, FAN Z.Specificity and some physicochemical characteristics of the antibacterial activity from blue crab Callinectes sapidus[J].Fish & Shellfish Immunology, 1996, 6(6):403-412.  

[28] HAUG T, KJUUL A K, STESVG K, et al.Antibacterial activity in four marine crustacean Decapods[J].Fish & Shellfish Immunology, 2002, 12(5):371-385.  

[29] HOQ M I, SERAJ M U, CHOWDHURY S.Isolation and characterization of antibacterial peptides from the mud-crab, Scylla serrata[J].Pakistan Journal of Biological Sciences, 2003, 6(15):1345-1353.  

[30] 黄文树, 王克坚, 李少菁.甲壳动物抗菌肽研究进展[J].海洋科学, 2005, 29(2):64-68.

[31] STEWART J E, ZWICKER B M.Natural and induced bactericidal activities in the hemolymph of the lobster, Homarus americanus:products of hemocyte-plasma interaction[J].Canadian Journal of Microbiology, 1972, 18(9):1499-1509.  

[32] JAYASANKAR V, SUBRAMONIAM T.Antibacterial activity of seminal plasma of the mud crab Scylla serrata (Forskal)[J].Journal of Experimental Marine Biology and Ecology, 1999, 236(2):253-259.  

[33] HUANG W S, WANG K J, YANG M, et al.Purification and part characterization of a novel antibacterial protein scygonadin, isolated from the seminal plasma of mud crab, Scylla serrata (Forskl, 1775)[J].Journal of Experimental Marine Biology and Ecology, 2006, 339(1):37-42.  

[34] 潘鲁青, 金彩霞.甲壳动物血蓝蛋白研究进展[J].水产学报, 2008, 32(3):484-491.

[35] CHARLET M, CHERNYSH S, PHILIPPE H, et al.Innate immunity:isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis[J].Journal of Biological Chemistry, 1996, 271(36):21808-21813.  

[36] MITTA G, HUBERT F, NOL T, et al.Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis[J].European Journal of Biochemistry, 1999, 265(1):71-78.  

[37] MITTA G, VANDENBULCKE F, HUBERT F, et al.Involvement of mytilins in mussel antimicrobial defense[J].Journal of Biological Chemistry, 2000, 275(17):12954-12962.  

[38] 荆昭.毛蚶(Scapharca kagoshimensis)血红蛋白的类酚氧化酶性质及其抗菌活性研究.博士学位论文.青岛:中国海洋大学, 2011.

[39] 汪青, 林志华, 包永波, 等.泥蚶(Tegillarca granosa)血红蛋白基因(Tg-HbⅡA)克隆、分析及免疫表达研究[J].海洋与湖沼, 2012, 43(1):88-94.

[40] AZUMI K, YOKOSAWA H, ISHI S.Haolcyamines:novel antimicrobial tetrapeptide-like substances isolated from the hemocytes of the solitary ascidian Halocynthia roretzi[J].Biochemistry, 1990, 29:156-165.

[41] LEE I H, LEE Y S, KIM C H, et al.Dicynthaurin:an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium[J].Biochimica et Biophysica Acta, 2001, 1527(3):141-148.  

[42] JANG W S, KIM K N, LEE Y S, et al.Halocidin:a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium[J].FEBS Letters, 2002, 521(1/2/3):81-86.

[43] LEE I H, ZHAO C Q, CHO Y, et al.Clavanins, α-helical antimicrobial peptides from tunicate hemocytes[J].FEBS Letters, 1997, 400(2):158-162.  

[44] ZHAO C Q, LIAW L, LEE I H, et al.cDNA cloning of three cecropin-like antimicrobial peptides (styelins) from the tunicate, Styela clava[J].FEBS Letters, 1997, 412(1):144-148.  

[45] FEDDERS H, MICHALEK M, GRTZINGER J, et al.An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of hemocytes of the marine invertebrate Ciona intestinalis[J]. Biochemical Journal, 2008, 416:65-75.

[46] 梁英, 黄文树, 关瑞章, 等.鱼类表皮黏液抗菌蛋白/肽研究进展[J].水生生物学报, 2009, 33(5):963-969.

[47] ⅡJIMA N, TANIMOTO N, EMOTO Y, et al.Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major[J].European Journal of Biochemistry, 2003, 270(4):675-686.  

[48] SHIKE H, LAUTH X, WESTERMAN M E, et al.Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge[J].European Journal of Biochemistry, 2002, 269:2232-2237.

[49] 王克坚.海洋鱼类和青蟹抗菌肽hepcidin和scygonadin的研究[J].厦门大学学报:自然科学版, 2011, 50(2):418-424.

[50] 温武军.鲤抗菌肽基因的克隆及其功能研究.博士学位论文.济南:山东师范大学, 2011.

[51] MASSO-SILVA J, DIAMOND G, MACIAS-RODRIGUEZ M, et al.Genomic organization and tissue-specific expression of hepcidin in the pacific mutton hamlet, Alphestes immaculatus (Breder, 1936)[J].Fish & Shellfish Immunology, 2011, 31(6):1297-1302.  

[52] QU H D, CHEN B, PENG H, et al.Molecular cloning, recombinant expression, and antimicrobial activity of EC-hepcidin3, a new four-cysteine hepcidin isoform from Epinephelus coioides[J].Bioscience, Biotechnology, and Biochemistry, 2013, 77(1):103-110.  

[53] XU Q H, CHENG C H C, HU P, et al.Adaptive evolution of hepcidin genes in antarctic notothenioid fishes[J].Molecular Biology Evolution, 2008, 25(6):1099-1112.  

[54] YANG M, WANG, K J, CHEN J H, et al.Genomic organisation and tissue-specific expression analysis of hepcidin-like genes from black porgy (Acanthopagrus schlegelⅡ B.)[J].Fish & Shellfish Immunology, 2007, 23(5):1060-1071.  

[55] ZHANG Y A, ZOU J, CHANG C I, et al.Discovery and characterization of two types of liver-expressed antimicrobial peptide 2(LEAP-2) genes in rainbow trout[J].Veterinary Immunology Immunopathology, 2004, 101:259-269.

[56] 李华, 杨桂文, 温武军.鱼类抗菌肽研究概况[J].科技信息, 2010(2):144.

[57] HARWIG S S, SWIDEREK K M, KOKRYAKOV V N, et a1.Gallinacins:cysteine-rich antimicrbia1 peptides of chicken leukocytes[J].FEBS Letters, 1994, 342(3):281-285.  

[58] 洪胜辉, 武艳军, 龚道清.禽类β-防御素的研究进展[J].中国饲料, 2011(22):8-15.

[59] LYNN D J, HIGGS R, GAINES S, et al.Bioinformatic discovery and initial characterization of nine novel antimicrobial peptides genes in chicken[J].Imunogenetics, 2004, 56(2):170-177.

[60] 赵军明, 荣光, 周汉林.鸡源抗菌肽的研究进展及展望[J].热带农业科学, 2011, 31(3):94-98.

[61] DRIDER D, FIMLAND G, HÉCHARD Y, et al.The continuing story of class Ⅱ a bacteriocins[J].Microbiology and Molecular Biology Reviews, 2006, 70(2):564-582.  

[62] TODOROV S D.Bacteriocins from Lactobacillus plantarum production, genetic organization and mode of action[J].Brazilian Journal of Microbiology, 2009, 40(2):209-221.  

[63] PHADKE S M, LAZAREVIC V, BAHR C C, et al.Lentivirus lytic peptide 1 perturbs both outer and inner membranes of Serratia marcescens[J].Antimicrobial Agents and Chemotherapy, 2002, 46(6):2041-2045.  

[64] JUNG D, POWERS J P, STRAUS S K, et al.Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes[J].Chemistry and Physics of Lipids, 2008, 154(2):120-128.  

[65] LI P, CHEN H C, HE B, et al.An antimicrobial peptide gene found in the male reproductive system of rats[J].Science, 2001, 291(5509):1783-1785.  

[66] JENSSEN H, HAMILL P, HANCOCK R E W.Peptide antimicrobial agents[J].Clinical Microbiology Reviews, 2006, 19(3):491-511.  

[67] MYGIND P H, FISCHER R L, SCHNORR K M, et al.Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus[J].Nature, 2005, 437(7061):975-980.  

[68] SHARMA A, SHARMA R, IMAMURA M, et al.Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, cofers enhanced resistance to bacterial leaf blight in rice[J].FEBS Letters, 2000, 484(1):7-11.  

[69] 田长恩, 王正询, 陈韬, 等.抗菌肽D基因导入番茄及转基因植株的鉴定[J].遗传, 2000, 22(2):86-89.

[70] 马卫明, 余锐萍, 靳红, 等.猪小肠抗菌肽的抗菌作用研究[J].中国兽医杂志, 2005, 41(1):3-7.

[71] 皮灿辉, 彭永鹤, 李永新, 等.抗菌肽制剂对母猪死胎率和仔猪成活率的影响[J].中国畜牧兽医, 2008, 35(6):90-91.

[72] KER D E, PLAUT K, BRAMLEY A J, et al.Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice[J].Nature Biotechnology, 2001, 19(1):66-70.  

[73] 吴俊强, 曹立亭, 胡松华.乳酸链球菌素治疗奶牛乳房炎效果观察[J].中国奶牛, 2008(7):41-44.

[74] ZHANG J X, ZHANG S F, WANG T D, et al.Mammary gland expression of antibacterial peptide genes to inhibit bacterial pathogens causing mastitis[J].Journal of Dairy Science, 2007, 90(11):5218-5225.  

[75] 宋理平, 胡斌, 王爱英, 等.抗菌肽对凡纳滨对虾生长和机体免疫的影响[J].广东海洋大学学报, 2010, 30(3):28-32.

[76] 姜珊, 王宝杰, 刘梅, 等.饲料中添加重组抗菌肽对吉富罗非鱼生长性能及免疫力的影响[J].中国水产科学, 2011, 18(6):1308-1314.

[77] CHIOU P P, KHOO J, BOLS N S, et al.Efiects of linear cationic α-helical antimicrobial peptides on immune-relevant genes in trout macrophages[J].Developmental and Comparative Immunology, 2006, 30(9):797-806.  

[78] WANG Y D, KUNG C W, CHI S C, et al.Inactivation of nervous necrosis virus infecting grouper (Epinephelus coioides) by epinecidin-1 and hepcidin 1-5 antimicrobial peptides, and downregulation of Mx2 and Mx3 gene expressions[J].Fish & Shellfish Immunology, 2010, 28(1):113-120.  

[79] OTVOS L, Jr, CUDIC M, CHUA B Y, et al.An insect antibacterial peptide-based drug delivery system[J].Molecular Pharmaceutics, 2004, 1(3):220-232.  

[80] KIM Y C, LATE S, BANQA A K, et al.Biochemical enhancement of transdermal delivery with magainin peptide:modification of electrostatic interactions by changing pH[J].International Journal of Pharmaceutics, 2008, 362(1/2):20-28.

[81] 岳昌武, 莫宁萍, 刘坤祥, 等.抗菌肽的结构特点.作用机理及其应用前景[J].安徽农业科学, 2008, 36(5):1736-1739.

[82] PETERS B M, SHIRTLIFF M E, JABRA-RIZK M A.Antimicrobial peptides:primeval molecules or future drugs?[J].PLoS Pathogens, 2010, 6(10):e1001067.

[83] PERRON G G, ZASLOF M, BELL G.Experimental evolution of resistance to an antimicrobial peptide[J].Proceedings the Royal Society B: Biological Sciences, 2006, 273(1583):251-256.  

[84] BROUWER C P, WULFERINK M, WELLING M M.The pharmacology of radiolabeled cationic antimicrobial peptides[J].Journal of Pharmaceutical Sciences, 2008, 97(5):1633-1651.