综述 Review

叶酸对动物卵母细胞质量的影响及其作用机制

  • 宋洁 ,
  • 徐盛玉 ,
  • 杨双源 ,
  • 吴德
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  • 四川农业大学动物营养研究所, 雅安 625014

收稿日期: 2013-08-14

  网络出版日期: 2013-12-24

基金资助

教育部创新团队计划(IRT0555)

Effects of Folate on Oocytes Quality of Animals and Its Action Mechanism

  • SONG Jie ,
  • XU Shengyu ,
  • YANG Shuangyuan ,
  • WU De
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  • Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2013-08-14

  Online published: 2013-12-24

摘要

在雌性动物繁殖过程中,健康卵母细胞的形成是保证正常受精、胚胎发育以及有性生殖能力的物质基础。叶酸作为一碳单位载体参与DNA、RNA、蛋白质的合成,在配子形成、胎儿发育等细胞快速生长分化过程中必不可少。近年来,叶酸对卵母细胞质量影响的研究取得了一系列新进展,研究表明,叶酸可以通过促细胞分裂、抗氧化、促核酸合成和促甲基化反应等途径影响卵母细胞质量。本文就叶酸对动物卵母细胞质量的影响及其作用机制做一综述。

本文引用格式

宋洁 , 徐盛玉 , 杨双源 , 吴德 . 叶酸对动物卵母细胞质量的影响及其作用机制[J]. 动物营养学报, 2014 , 26(1) : 63 -68 . DOI: 10.3969/j.issn.1006-267x.2014.01.009

Abstract

In female reproduction, the formation of healthy oocytes is the material basis of normal fertilization, embryo development, as well as sexual reproduction. As a carrier of one-carbon units involved in the synthesis of DNA, RNA, and protein, folate is absolutely necessary in the process of cell growth and differentiation, such as the formation of gametes and fetal development etc. In recent years, researches found that folate influences oocytes quality through promoting cell division, antioxidation, nucleic acid synthesis and methylation reaction pathway etc. Here, the paper reviews the effects of folate on oocytes quality of animals and its action mechanism.

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