动物营养学报 >

2014 , Vol. 26 >Issue 9: 2451 - 2456

DOI: https://doi.org/10.3969/j.issn.1006-267x.2014.09.002

综述 Review

必需氨基酸通过哺乳动物雷帕霉素靶蛋白信号通路调控乳蛋白合成的研究进展

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  • 1. 中国农业科学院北京畜牧兽医研究所, 农业部奶产品质量安全风险评估实验室(北京), 北京 100193;
    2. 甘肃农业大学动物科学技术学院, 兰州 730070;
    3. 农业部奶及奶制品质量监督检验测试中心(北京), 北京 100193;
    4. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193
高海娜（1987-），女，青海西宁人，硕士，动物营养与饲料科学专业。E-mail：gaohaian103@126.com

收稿日期: 2014-04-25

  网络出版日期: 2014-09-10

基金资助

国家重点基础研究发展计划（2011CB100805）；现代农业产业技术体系专项资金（nycytx-04-01）；中国农业科学院科技创新工程（ASTIP-IAS12）

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Research Progress on the Regulation of Milk Protein Synthesis by Essential Amino Acids through Mammalian Target of Rapamycin Signaling Pathway

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  • 1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
    3. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
    4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2014-04-25

  Online published: 2014-09-10

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摘要

最近的研究表明，必需氨基酸不仅可以作为合成乳蛋白的底物，还可以作为信号分子调控乳蛋白的合成。不同的必需氨基酸通过哺乳动物雷帕霉素靶蛋白（mTOR）信号通路调控乳蛋白合成的作用也不相同，既包括正调控作用，也包括负调控作用。研究不同必需氨基酸调控乳蛋白合成的分子机制将为提高乳蛋白合成率提供理论基础。本文综述了mTOR信号通路及必需氨基酸通过mTOR信号通路调控乳蛋白的合成的研究进展，为揭示必需氨基酸作为蛋白质合成底物及细胞信号分子在乳蛋白合成过程中的作用机制提供研究方向。

关键词： 必需氨基酸; mTOR; 乳蛋白

本文引用格式

高海娜, 郑楠, 胡菡, 王加启 . 必需氨基酸通过哺乳动物雷帕霉素靶蛋白信号通路调控乳蛋白合成的研究进展[J]. 动物营养学报, 2014 , 26(9) : 2451 -2456 . DOI: 10.3969/j.issn.1006-267x.2014.09.002

Abstract

Recent studies showed that the essential amino acids not only functioned as the substrates of milk protein synthesis, but also as the signaling molecules to regulate milk protein synthesis. The regulation of milk casein by different essential amino acids through mammalian target of rapamycin (mTOR) signaling pathways is different, some amino acids have positive regulatory roles and others have negative ones. It is essential to further study on the molecular mechanism of milk protein synthesis regulation by different essential amino acids. In this review, the downstream of mTOR signaling pathways and milk protein synthesis regulation by essential amino acids through the mTOR signaling pathways were summarized.

Key words： essential amino acids; mTOR; casein

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