综述 Review

营养素对动物表观遗传的影响及其机制

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  • 1. 中国农业科学院饲料研究所, 农业部饲料生物技术重点实验室, 北京 100081;
    2. 河北工程大学农学院, 邯郸 056021
王海超(1990-),男,河北临漳人,硕士研究生,从事反刍动物营养学研究。E-mail:qiusuoba@163.com

收稿日期: 2014-04-18

  网络出版日期: 2014-09-10

基金资助

农业部公益性行业(农业)科研专项“南方地区幼龄草食畜禽饲养技术研究”(201303143);国家肉羊产业技术体系建设专项资金(CARS-39)

Effects and Mechanisms of Nutrients on Epigenetic in Animals

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  • 1. Key Laboratory of Feed Biotechnology of Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China;
    2. College of Agriculture, Hebei University of Engineering, Handan 056021, China

Received date: 2014-04-18

  Online published: 2014-09-10

摘要

表观遗传是环境因素和细胞内的遗传物质相互作用的结果。表观遗传学是在DNA碱基序列不变的前提下引起的基因表达或细胞表观型变化的一种遗传现象,具体表现在以下3个既相互独立又相互作用的方面:DNA甲基化、组蛋白修饰和microRNA(miRNA)调控。本文就表观遗传的研究进展及营养素对动物表观遗传的影响及其机制进行综述。

本文引用格式

王海超, 张乐颖, 刁其玉 . 营养素对动物表观遗传的影响及其机制[J]. 动物营养学报, 2014 , 26(9) : 2463 -2469 . DOI: 10.3969/j.issn.1006-267x.2014.09.004

Abstract

Epigenetic is the result of interaction between environment factors and the genetic materials in cells. Epigenetics is defined a genetic phenomenon which may alter gene expression and cell phenotype, but which do not involve changes in DNA base sequences. These include three aspects, which both independent and interaction: DNA methylation, histone modification and microRNA (miRNA) regulation. This review firstly focused on the research advance in epigenetic and then on the effects and mechanisms of nutrients on epigenetics in animals.

参考文献

[1] ADAMS C A,岳洪源,齐广海.基因组、基因表达与饲料[J].饲料与畜牧,2008(8):16-19.

[2] ADAMS C A,岳洪源,齐广海.基因组、基因表达与饲料[J].饲料与畜牧,2008(9):20-23.

[3] VAN STRATEN E M E,BLOKS V W,HUIJKMAN N C A,et al.The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction[J].American Journal of Physiology:Regulatory Integrative and Comparative Physiology,2010,298(2):R275-R282.

[4] PENTINAT T,RAMON-KRAUEL M,CEBRIA J,et al.Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition[J].Endocrinology,2010,151(12):5617-5623.  

[5] JIMENEZ-CHILLARON J C,HERNANDEZ-VALENCIA M,LIGHTNER A,et al.Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight[J].Diabetologia,2006,49(8):1974-1984.  

[6] JIMENEZ-CHILLARON J C,HERNANDEZ-VALENCIA M,REAMER C,et al.β-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes-a murine model[J].Diabetes,2005,54(3):702-711.  

[7] VERCELLI D.Genetics,epigenetics,and the environment:switching,buffering,releasing[J].Journal of Allergy and Clinical Immunology,2004,113(3):381-386.  

[8] GOLDBERG A D,ALLIS C D,BERNSTEIN E.Epigenetics:a landscape takes shape[J].Cell,2007,128(4):635-638.  

[9] CANANI R B,DI COSTANZO M,LEONE L,et al.Epigenetic mechanisms elicited by nutrition in early life[J].Nutrition Research Reviews,2011,24(2):198-205.  

[10] REIK W.Stability and flexibility of epigenetic gene regulation in mammalian development[J].Nature,2007,447(7143):425-432.  

[11] FELTUS F A,LEE E K,COSTELLO J F,et al.DNA motifs associated with aberrant CpG island methylation[J].Genomics,2006,87(5):572-579.  

[12] FENG Y Q,DESPRAT R,FU H Q,et al.DNA methylation supports intrinsic epigenetic memory in mammalian cells[J].PLoS Genetics,2006,2(4): e65.

[13] KOUZARIDES T.Chromatin modifications and their function[J].Cell,2007,128(4):693-705.  

[14] SURANI M A,HAYASHI K,HAJKOVA P.Genetic and epigenetic regulators of pluripotency[J].Cell,2007,128(4):747-762.  

[15] JIMENÉZ-CHILLARÓN J C,DÍAZ R,MARTÍNEZ D,et al.The role of nutrition on epigenetic modifications and their implications on health[J].Biochimie,2012,94(11):2242-2263.  

[16] LIU H C,HICKS J A,TRAKOOLJUL N,et al.Current knowledge of microRNA characterization in agricultural animals[J].Animal Genetics,2010,41(3):225-231.  

[17] LEWIS B P,SHIH I H,JONES-RHOADES M W,et al.Prediction of mammalian microRNA targets[J].Cell,2003,115(7):787-798.  

[18] REES W D,HAY S M,BROWN D S,et al.Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses[J].The Journal of Nutrition,2000,130(7):1821-1826.

[19] CARONE B R,FAUQUIER L,HABIB N,et al.Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals[J].Cell,2010,143(7):1084-1096.  

[20] JOUSSE C,PARRY L,LAMBERT-LANGLAIS S,et al.Perinatal undernutrition affects the methylation and expression of the leptin gene in adults:implication for the understanding of metabolic syndrome[J].The FASEB Journal,2011,25(9):3271-3278.  

[21] VAN STRATEN E M E,BLOKS V W,HUIJKMAN N C A,et al.The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction[J].American Journal of Physiology:Regulatory Integrative and Comparative Physiology,2010,298(2):R275-R282.

[22] LILLYCROP K A,PHILLIPS E S,TORRENS C,et al.Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring[J].British Journal of Nutrition,2008,100(2):278-282.

[23] LILLYCROP K A,SLATER-JEFFERIES J L,HANSON M A,et al.Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications[J].British Journal of Nutrition,2007,97(6):1064-1073.  

[24] DUDLEY K J,SLOBODA D M,CONNOR K L,et al.Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation[J].PLoS One,2011,6(7):e21662.

[25] VUCETIC Z,KIMMEL J,TOTOKI K,et al.Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes[J].Endocrinology,2010,151(10):4756-4764.  

[26] COLMAN R J,ANDERSON R M,JOHNSON S C,et al.Caloric restriction delays disease onset and mortality in rhesus monkeys[J].Science,2009,325(5937):201-204.  

[27] COOPER T M,MOCKETT R J,SOHAL B H,et al.Effect of caloric restriction on life span of the housefly,musca domestica[J].The FASEB Journal,2004,18(13):1591-1593.

[28] FONTANA L,VILLAREAL D T,WEISS E P,et al.Calorie restriction or exercise:effects on coronary heart disease risk factors.A randomized,controlled trial[J].American Journal of Physiology:Endocrinology and Metabolism,2007,293(1):E197-E202.

[29] RAYCHAUDHURI N,RAYCHAUDHURI S,THAMOTHARAN M,et al.Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring[J].Journal of Biological Chemistry,2008,283(20):13611-13626.  

[30] TOSH D N,FU Q,CALLAWAY C W,et al.Epigenetics of programmed obesity:alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs.delayed postnatal catch-up growth[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2010,299(5):G1023-G1029.

[31] UNTERBERGER A,SZYF M,NATHANIELSZ P W,et al.Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons[J].Journal of Medical Primatology,2009,38(4):219-227.  

[32] LY A,LEE H,CHEN J M,et al.Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring[J].Cancer Research,2011,71(3):988-997.  

[33] MCKAY J A,WALTHAM K J,WILLIAMS E A,et al.Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring[J].Genes and Nutrition,2011,6(2):189-196.  

[34] SIE K K Y,MEDLINE A,VAN WEEL J,et al.Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring[J].Gut,2011,60(12):1687-1694.  

[35] NICULESCU M D,CRACIUNESCU C N,ZEISEL S H.Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains[J].The FASEB Journal,2006,20(1):43-49.  

[36] PROBST A V,DUNLEAVY E,ALMOUZNI G.Epigenetic inheritance during the cell cycle[J].Nature Reviews Molecular Cell Biology,2009,10(3):192-206.  

[37] JONES P A,LIANG G N.Rethinking how DNA methylation patterns are maintained[J].Nature Reviews Genetics,2009,10(11):805-811.  

[38] OLLIKAINEN M,SMITH K R,JOO E J H,et al.DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome[J].Human Molecular Genetics,2010,19(21):4176-4188.  

[39] MCKAY J A,MATHERS J C.Diet induced epigenetic changes and their implications for health[J].Acta Physiologica,2011,202(2):103-118.  

[40] LINK A,BALAGUER F,GOEL A.Cancer chemoprevention by dietary polyphenols:promising role for epigenetics[J].Biochemical Pharmacology,2010,80(12):1771-1792.  

[41] LIN C J,KANG J H,ZHENG R L.Oxidative stress is involved in inhibition of copper on histone acetylation in cells[J].Chemico-Biological Interactions,2005,151(3):167-176.  

[42] BALASUBRAMANIAN S,ADHIKARY G,ECKERT R L.The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival[J].Carcinogenesis,2010,31(3):496-503.  

[43] ESQUELA-KERSCHER A,SLACK F J.Oncomirs-microRNAs with a role in cancer[J].Nature Reviews Cancer,2006,6(4):259-269.  

[44] CHUANG J C,JONES P A.Epigenetics and microRNAs[J].Pediatric Research,2007,61(2):24R-29R.

[45] FRAGA M F,BALLESTAR E,PAZ M F,et al.Epigenetic differences arise during the lifetime of monozygotic twins[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(30):10604-10609.  

[46] JENSEN P.Behaviour epigenetics—the connection between environment,stress and welfare[J].Applied Animal Behaviour Science,2014,157:1-7.

[47] FEIL R.Environmental and nutritional effects on the epigenetic regulation of genes[J].Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis,2006,600(1/2):46-57.

[48] JIRTLE R L,SKINNER M K.Environmental epigenomics and disease susceptibility[J].Nature Reviews Genetics,2007,8(4):253-262.  
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