综述 Review

革兰氏阴性益生菌大肠杆菌Nissle1917益生机理及其在仔猪方面的应用

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  • 西南大学动物科技学院, 生物饲料与分子营养实验室, 重庆 400715
邓欢(1991-),女,重庆市人,硕士研究生,研究方向为动物应用微生物。E-mail:dh199112@hotmail.com

收稿日期: 2014-04-08

  网络出版日期: 2014-09-10

基金资助

国家973重点基础研究发展计划项目(2013CB127303);中央高校基本业务费专项资金(XDJK2014B028);重庆市自然科学基金(cstc2012jjA80001);国家循环农业项目(2012BAD14B18)

Probiotic Mechanism of Gram Negative Probiotics E. coli Nissle 1917 and Its Application in Piglets Raising

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  • Key Laboratory for Bio-Feed and Animal Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China

Received date: 2014-04-08

  Online published: 2014-09-10

摘要

革兰氏阴性菌大肠杆菌(E.coli)Nissle 1917(EcN)是非乳酸益生菌中研究最多的益生菌。EcN血清型为O6:K5:H1,具有独特的基因组、半粗糙O6-脂多糖(LPS)表型、K5型荚膜、3种不同的菌毛(F1A、F1C和卷曲菌毛)。EcN具有小菌素和铁摄取系统等特殊适应性因子,在与其他微生物竞争中起关键作用。EcN能长期稳定定植于肠道,与肠上皮细胞相互作用,发挥免疫调节生物学功能。本文就EcN的特征、定植机制、免疫调节机理和在仔猪方面应用的研究现状进行综述,以期为益生菌EcN和其他益生革兰氏阴性杆菌在动物方面研究和应用提供参考。

本文引用格式

邓欢, 赖星, 孙志洪, 陈澄, 石宝石, 唐志如 . 革兰氏阴性益生菌大肠杆菌Nissle1917益生机理及其在仔猪方面的应用[J]. 动物营养学报, 2014 , 26(9) : 2476 -2482 . DOI: 10.3969/j.issn.1006-267x.2014.09.006

Abstract

A gram-negative strain E. coli Nissle 1917 (EcN) is the most researched probiotic except lactic acid bacteria. EcN, serotyping of O6 : K5 : H1, has special genome, presents semi-rough O6-lipopolysaccharide(LPS) phenotype, K5 type and 3 different fimbriae (F1A, F1C and a kind of curli fimbriae capsule). The iron uptake system and the microcin of EcN, acting as their "fitness factor", are essential to antagonizing other bacteria. EcN has long-term steady colonization in the gut, interact with intestinal epithelial cells and develop immunomodulation biological function. This paper reviewed the futures, colonization mechanism, immunomodulation mechanism of EcN and its application in piglets raising, which will provide reference for further study on EcN and other probiotic gram-negative bacteria in animal intestine.

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