[1] SMITH F,CLARK J E,OVERMAN B L,et al.Early weaning stress impairs development of mucosal barrier function in the porcine intestine[J].American Journal of Physiolog:Gastrointestinal and Liver Physiology,2010,298(3):G352-G363.
[2] CUKROWSKA B,LODLNOVA-ZADNLKOVA R,ENDERS C,et al.Specific proliferative and antibody responses of premature infants to intestinal colonization with nonpathogenic probiotic
E.coli strain Nissle 1917[J].Scandinavian Journal of Immunology,2002,55(2):204-209.

[3] GROZDANOV L,RAASCH C,SCHULZE J,et al.Analysis of the genome structure of the nonpathogenic probiotic
Escherichia coli strain Nissle 1917[J].Journal of Bacteriology,2004,186(16):5432-5441.

[4] BLUM G,HACKER J,MARRE R.Properties of
Escherichia coli strains of serotype O6[J].Infection,1995,23:234-236.
[5] LASARO M A,SALINGER N,ZHANG J,et al.F1C fimbriae play an important role in biofilm formation and intestinal colonization by the
Escherichia coli commensal strain Nissle 1917[J].Applied and Environmental Microbiology,2009,75:246-251.
[6] VALDEBENITO M,CRUMBLISS A L,WINKELMANN G,et al.Environmental factors influence the production of enterobactin,salmochelin,aerobactin,and yersiniabactin in
Escherichia coli strain Nissle 1917[J].International Journal of Medical Microbiology,2006,296:513-520.
[7] LÉVEILLÉ S,CAZA M,JOHNSON J R,et al.Iha from an
Escherichia coli urinary tract infection outbreak clonal group A strain is expressed
in vivo in the mouse urinary tract and functions as a catecholate siderophore receptor[J].Infection and Immunity,2006,74:3427-3436.
[8] HANCOCK V,VEJBORG R M,KLEMM P.Functional genomics of probiotic
Escherichia coli Nissle 1917 and 83972,and UPEC strain CFT073:comparison of transcriptomes,growth and biofilm formation[J].Molecular Genetics and Genomics,2010,284:437-454.
[9] PATZER S I,BAQUERO M R,BRAVO D,et al.The colicin G,H and X determinants encode microcins M and H47,which might utilize the catecholate siderophore receptors FepA,Cir,Fiu and IroN[J].Microbiology,2003,149(9):2557-2570.

[10] BURNS S M,HULL S I.Comparison of loss of serum resistance by defined lipopolysaccharide mutants and an acapsular mutant of uropathogenic
Escherichia coli O75:K5[J].Infection and Immunity,1998,66:4244-4253.
[11] HUGHES C,PHILLIPS R,ROBERTS A P.Serum resistance among
Escherichia coli strains causing urinary tract infection in relation to O type and the carriage of hemolysin,colicin,and antibiotic resistance determinants[J].Infection and Immunity,1982,35:270-275.
[12] HAFEZ M,HAYES K,GOLDRICK M,et al.The K5 capsule of
Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction[J].Infection and Immunity,2009,77:2995-3003.
[13] HAFEZ M,HAYES K,GOLDRICK M,et al.The K5 capsule of
Escherichia coli strain Nissle 1917 is important in stimulating expression of Toll-like receptor 5,CD14,MyD88,and TRIF together with the induction of interleukin-8 expression via the mitogen-activated protein kinase pathway in epithelial cells[J].Infection and Immunity,2010,78:2153-2162.
[14] SPLICHAL I,FAGERHOL M K,TREBICHAVSKY I,et al.The effect of intestinal colonization of germ-free pigs with
Escherichia coli on calprotectin levels in plasma,intestinal and bronchoalveolar lavages[J].Immunobiology,2005,209:681-687.
[15] BAQUERO F,MORENO F.The microcins[J].FEMS Microbiology Letters,2006,23:117-124.
[16] VASSILIADIS G,DESTOUMIEUX-GARZON D,LOMBARD C,et al.Isolation and characterization of two members of the siderophore-microcin family,microcins M and H47[J].Antimicrobial Agents and Chemotherapy,2010,54:288-297.
[17] WEHKAMP J,HARDER J,WEHKAMP K,et al.NF-κB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by
Escherichia coli Nissle 1917:a novel effect of a probiotic bacterium[J].Infection and Immunity,2004,72:5750-5758.
[18] SCHLEE M,WEHKAMP J,ALTENHOEFER A,et al. Induction of human beta-defensing 2 by the probiotic
Escherichia coli Nissle 1917 is mediated through flagellin[J].Infection and Immunity,2007,75:2399-2407.
[19] UKENA S N,SINGH A,DRINGENBERG U,et al.Probiotic
Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity[J].PLoS One,2007,2:e1308.
[20] ZYREK A A,CICHON C,HELMS S,et al.Molecular mechanisms underlying the probiotic effects of
Escherichia coli Nissle 1917 involve ZO-2 and PKCζ redistribution resulting in tight junction and epithelial barrier repair[J].Cellular Microbiology,2007,9:804-816.
[21] CROSS M L,GANNER A,TEILAB D,et al.Patterns of cytokine induction by gram-positive and gram-negative probiotic bacteria[J].FEMS Immunology and Medical Microbiology,2004,42:173-180.
[22] UKENA S N,WESTENDORF A M,HANSEN W,et al.The host response to the probiotic
Escherichia coli strain Nissle 1917:specific up-regulation of the proinflammatory chemokine MCP-1[J].BMC Medical Genetics,2005,6:43.
[23] SKAAR E P.The battle for iron between bacterial pathogens and their vertebrate hosts[J].PLoS Pathogens,2010,6:e1000949.
[24] STURM A,RILLING K,BAUMGART D C,et al.
Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via Toll-like receptor 2 signaling[J].Infection and Immunity,2005,73:1452-1465.
[25] GUZY C,PACLIK D,SCHIRBEL A,et al.The probiotic
Escherichia coli strain Nissle 1917 induces γδ T cell apoptosis via caspase-and FasL-dependent pathways[J].International Immunology,2008,20:829-840.
[26] BICKERT T,TRUJILLO-VARGAS C M,DUECHS M,et al.Probiotic
Escherichia coli Nissle 1917 suppresses allergen-induced Th2 responses in the airways[J].International Archives of Allergy and Immunology,2009,149:219-230.
[27] HELWIG U,LAMMERS K M,RIZZLLO F,et al.
Lactobacilli,Bifidobacteria and
E.coli Nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells[J].World Journal of Gastroenterology,2006,12:5978-5986.
[28] ARRIBAS B,RODRIGUEZ-CABEZAS M E,CAMUESCO D,et al.A probiotic strain of
Escherichia coli Nissle 1917,given orally exerts local and systemic anti-inflammatory effects in lipopolysaccharide-induced sepsis in mice[J].British Journal of Pharmacology,2009,157:1024-1033.
[29] AGRAWAL S,AGRAWAL A,DOUGHTY B,et al.Cutting edge:different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos[J].The Journal of Immunology,2003,171:4984-4989.
[30] GRABIG A,PACLIK D,GUZY C,et al.
Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways[J].Infection and Immunity,2006,74:4075-4082.
[31] LAMMERS K M,HELWIG U,SWENNEN E,et al.Effect of probiotic strains on interleukin 8 production by HT29/19A cells[J].The American Journal of Gastroenterology,2002,97:1182-1186.
[32] OTTE J M,MAHJURIAN-NAMARI R,BRAND S,et al.Probiotics regulate the expression of COX-2 in intestinal epithelial cells[J].Nutrition and Cancer,2008,61:103-113.
[33] KLETA S,STEINRUCK H,BREVES G,et al.Detection and distribution of probiotic
Escherichia coli Nissle 1917 clones in swine herds in Germany[J].Journal of Applied Microbiology,2006,101(6):1357-1366.

[34] GUNZER F,HENNIG-PAUKA I,WALDMANN K H,et al.Gnotobiotic piglets develop thrombotic microangiopathy after oral infection with enterohemorrhagic
Escherichia coli[J].American Journal of Clinical Pathology,2002,118(3):364-375.

[35] 唐志如,邓欢,孙卫忠,等.口服益生菌
Escherichia coli Nissle 1917调控断奶仔猪空肠粘膜屏障功能的机理研究[J].畜牧兽医学报,2014,45(1):78-86.
[36] DUNCKER S C,LORENTZ A,SCHROEDER B,et al.Effect of orally administered probiotic
E.coli strain Nissle 1917 on intestinal mucosal immune cells of healthy young pigs[J].Veterinary Immunology Immunopathology,2006,111:239-250.
[37] SPLICHALOVA A,TREBICHAVSKY I,RADA V,et al.Interference of
Bifidobacterium choerinum or
Escherichia coli Nissle 1917 with
Salmonella Typhimurium in gnotobiotic piglets correlates with cytokine patterns in blood and intestine[J].Clinical and Experiment Immunology,2011,163:242-249.
[38] SCHROEDER B,DUNCKER S,BARTH S,et al.Preventive effects of the probiotic
Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection[J].Digestive Diseases and Sciences,2006,51:724-731.