综述 Review

色氨酸对哺乳动物母-胎界面的免疫调节作用及其机制

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  • 1. 南昌大学食品科学与技术国家重点实验室, 南昌 330047;
    2. 南昌大学食品学院, 南昌 330031;
    3. 中国科学院亚热带农业生态研究所, 长沙 410125;
    4. 德克萨斯A&M大学动物科学系, 克里奇 77843
阮征(1978—),男,湖北荆州人,教授,硕士生导师,主要从事营养代谢与免疫调节。E-mail:ruanzheng@ncu.edu.cn

收稿日期: 2014-08-13

  网络出版日期: 2015-01-23

基金资助

国家自然科学基金(31360552)

Immunoregulatory Effect and Mechanism of Tryptophan on Maternal-Fetal Interface of Mammals

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  • 1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;
    2. College of Food Science and Engineering, Nanchang University, Nanchang 330031, China;
    3. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    4. Department of Animal Science, Texas A&M University, College Station 77843, USA

Received date: 2014-08-13

  Online published: 2015-01-23

摘要

近年来,一些研究发现氨基酸对提高母猪繁殖能力具有重要的作用。少量的体内和体外试验研究表明,色氨酸及其代谢物能够提高母猪繁殖能力,降低流产率。本文综述了色氨酸及其犬尿氨酸代谢对哺乳动物(主要是猪和鼠)母-胎界面免疫调节(或免疫耐受)的影响,以及色氨酸及其代谢物(如犬尿氨酸和3-羟基犬尿氨酸)对哺乳动物母-胎界面蜕膜自 然杀伤(dNK)细胞、调节性T细胞(Treg)和17型辅助性T细胞(Th17)的调控作用以及可能的作用机制。

本文引用格式

阮征, 印遇龙, 伍国耀 . 色氨酸对哺乳动物母-胎界面的免疫调节作用及其机制[J]. 动物营养学报, 2014 , 26(10) : 2986 -2991 . DOI: 10.3969/j.issn.1006-267x.2014.10.010

Abstract

Recently, researchers found that amino acids could improve the reproductive capacity of sows. A few in vivo and in vitro studies showed that tryptophan and its metabolites could improve the reproductive capacity and reduce the abortion rate of sows. This paper reviewed the effect of tryptophan and its metabolites via kynurenine pathway on the immunoloregulation (or immunologic tolerance) of maternal-fetal interface of mammals (mainly pigs and rats), and the regulatory effect of tryptophan and its metabolites (such as kynurenine and 3-hydroxykynurenine) on decidual natural killer (dNK) cell, regulatory T cell (Treg) and type 17 helper T cell (Th17) in maternal-fetal interface of mammals and their possible mechanisms.

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