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营养与鱼类免疫研究进展

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  • 四川农业大学动物营养研究所, 成都 611130
周小秋(1966—),男,重庆垫江人,教授,博士生导师,主要从事营养与淡水鱼消化道健康及抗病营养研究。E-mail:zhouxq@sicau.edu.cn

收稿日期: 2014-08-13

  网络出版日期: 2015-01-23

基金资助

国家公益性行业(农业)科研专项经费项目(201003020);国家自然科学基金项目(30771671,30871926,31001116,31272674,31302197)

Advanced Research in Nutrition and Fish Immunity

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  • Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2014-08-13

  Online published: 2015-01-23

摘要

鱼类生长发育与疾病抵抗力密切相关,而营养物质在鱼类疾病抵抗力及其免疫调控中发挥着重要作用。已有研究表明部分营养物质可通过雷帕霉素靶蛋白(TOR)和核因子E2相关因子2(Nrf2)信号途径调控鱼类免疫器官细胞因子产生,降低鱼类免疫器官氧化损伤,从而保证其结构完整性和功能正常,进而提高鱼类非特异性和特异性免疫力,增强鱼类疾病抵抗力。本文就部分氨基酸(蛋氨酸和异亮氨酸)、脂溶性维生素(维生素A)、水溶性维生素(维生素B1、吡哆醇、泛酸、胆碱和肌醇)以及营养性添加物(蛋氨酸羟基类似物)等营养物质与鱼类疾病抵抗力、非特异和特异性免疫防御、免疫器官生长发育、结构完整性和抗氧化防御、细胞因子及其相关信号途径之间关系的研究进展作一综述。

本文引用格式

周小秋, 冯琳, 姜维丹, 吴培, 刘扬, 胡凯, 姜俊 . 营养与鱼类免疫研究进展[J]. 动物营养学报, 2014 , 26(10) : 3175 -3184 . DOI: 10.3969/j.issn.1006-267x.2014.10.032

Abstract

The growth and development of fish is tightly related to their disease resist ability, while nutrients play an important role in fish disease resistance and immune regulation. Existing results indicate that some nutrients can modulate fish cytokines production and decrease oxidative damage of immune organs through increase of antioxidant capacity via target of papamycin (TOR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways, and thus maintain the structural integrity and normal function of immune organs, finally improving the non-specific and specific immunity and enhancing the disease resistance of fish. This article reviewed the advanced research on the relationships between nutrients like partial amino acids (e.g. methionine and isoleucine), fat-soluble vitamins (e.g. vitamin A), water-soluble vitamins (e.g. thiamine, pyridoxine, pantothenic acid, choline and myo-inositol) and nutritive feed additives (e.g. methionine hydroxyl analogue) and the disease resistance, non-specific and specific immune defense, growth and development of immune organs, structural integrity, antioxidant defense, and cytokines as well as their related signaling pathways in fish.

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