综述 Review

多胺跨膜物质转运的机制

展开
  • 四川农业大学动物科技学院, 雅安 625014
王贵鸿(1992- ),男,四川遂宁人,本科生,动物科学专业。E-mail:709647841@qq.com

收稿日期: 2014-05-16

  网络出版日期: 2014-11-17

基金资助

国家自然科学基金(31201798);高等学校博士学科点专项科研基金项目(20105103120003);四川农业大学大学生科研兴趣培养计划项目(2013018)

Mechanisms of Transmembrane Transport of Polyamines

Expand
  • College of Animal Science and Technology, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2014-05-16

  Online published: 2014-11-17

摘要

多胺具有调控细胞增殖、分化和凋亡的功能,可参与动物繁殖、胚胎发育以及癌症发生发展等多种生物学过程。在动物机体中,多胺稳态是通过多胺跨膜物质转运和多胺代谢途径共同维持的。溶质转运蛋白(SLC)基因家族中的SLC3A2、SLC7A1、SLC12A8、SLC22A16、SLC22A1、SLC22A2、SLC22A3基因及其编码的蛋白质可参与多胺的跨膜物质转运;多胺代谢关键调控基因鸟氨酸脱羧酶(ODC)、鸟氨酸脱羧酶抗酶(OAZ)和鸟氨酸脱羧酶抗酶抑制剂(AZIN)对多胺跨膜物质转运也具有重要的调控功能;此外,金属阳离子、细胞膜跨膜电位和pH等内环境因素也可参与多胺转运的调节。因此,本文就多胺转运蛋白、多胺代谢相关基因和蛋白质以及内环境因素调控多胺跨膜物质转运的分子调控机制作一综述,以期为阐明多胺转运调控机制的研究奠定理论基础。

本文引用格式

王贵鸿, 马容, 康波, 姜冬梅, 何珲 . 多胺跨膜物质转运的机制[J]. 动物营养学报, 2014 , 26(11) : 3245 -3250 . DOI: 10.3969/j.issn.1006-267x.2014.11.009

Abstract

Polyamines are involved in several biological processes including reproduction, embryo development and cancer development, as well as play important roles in cell proliferation, differentiation and apoptosis. The homeostasis of polyamines is regulated strictly by transmembrane transporter and polyamine metabolically pathways. Solute carrier (SLC) gene family including SLC3A2, SLC7A1, SLC12A8, SLC22A16, SLC22A1, SLC22A2 and SLC22A3 genes and their protein could involve in the process of polyamine transmembrane transport; furthermore, the key regulatory genes of polyamine metabolism including ornithine decarboxylase (ODC), ornithine decarboxylase antizyme (OAZ) and ornithine decarboxylase antizyme inhibitorgenes (AZIN) genes could also regulate transmembrane transport of polyamines; moreover, the internal environmental factors including metal cation, transmembrane potential and pH also involved in the process of polyamine transport. Therefore, in this paper, the roles of the polyamine transporters, the key regulatory genes of polyamine metabolism and their proteins, and internal environmental factors mediating polyamine transport were reviewed.

参考文献

[1] WALLACE H M,NIIRANEN K.Polyamine analogues-an up date[J].Amino Acids,2007,33(2):261-265.  

[2] AGUDELO-ROMERO P,BORTOLLOTI C,PAIS M S,et al.Study of polyamines during grape ripening indicate an important role of polyamine catabolism[J].Plant Physiologyand Biochemistry2013,67:105-119.

[3] IGARASHI K,KASHIWAGI K.Polyamines:mysterious modulators of cellular functions[J].Biochemical and Biophysical Research Communications,2000,271(3):559-564.  

[4] UEMURA T,STRINGER D E,BLOHM-MANGONE K A,et al.Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2010,299(2):G517-G522.

[5] PHANSTIEL O Ⅳ,KAUR N,DELCROS J G.Structure-activity investigations of polyamine-anthracene conjugates and their uptake via the polyamine transporter[J].Amino Acids,2007,33(2):305-313.  

[6] ABDULHUSSEIN A A,WALLACE H M.Polyamines and membrane transporters[J].Amino Acids,2014,46(3):655-660.  

[7] KOEPSELL H,LIPS K,VOLK C.Polyspecific organic cation transporters:structure,function,physiological roles,and biopharmaceutical implications[J].Pharmaceutical Research,2007,24(7):1227-1251.  

[8] KOEPSELL H.Organic cation transporters in intestine,kidney,liver,and brain[J].Annual Review of Physiology,1998,60(1):243-266.  

[9] BUSCH A E,QUESTER S,ULZHEIMER J C,et al.Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1[J].The Journal of Biological Chemistry,1996,271(51):32599-32604.  

[10] WINTER T N,ELMQUIST W F,FAIRBANKS C A.OCT2 and MATE1 provide bidirectional agmatine transport[J].Molecular Pharmaceutics,2011,8(1):133-142.  

[11] POULIN R,ZHAO C,VERMA S,et al.Dependence of mammalian putrescine and spermidine transport on plasma-membrane potential:identification of an amiloride binding site on the putrescine carrier[J].The Biochemical Journal,1998,330(Suppl.3):1283-1291.

[12] POULIN R,CASERO R A,SOULET D.Recent advances in the molecular biology of metazoan polyamine transport[J].Amino Acids,2012,42(2/3):711-723.

[13] SALA-RABANAL M,LI D C,DAKE G R,et al.Polyamine transport by the polyspecific organic cation transporters OCT1,OCT2,and OCT3[J].Molecular Pharmaceutics,2013,10(4):1450-1458.  

[14] PALACÍN M,ESTÉVEZ R,BERTRAN J,et al.Molecular biology of mammalian plasma membrane amino acid transporters[J].Physiological Reviews,1998,78(4):969-1054.

[15] YANG Z,VENARDOS K,JONES E,et al.Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1:contribution to hypertension and endothelial dysfunction[J].Circulation,2007,115(10):1269-1274.

[16] DEVÉS R,BOYD C A.Transporters for cationic amino acids in animal cells:discovery,structure,and function[J].Physiological Reviews,1998,78(2):487-545.

[17] SHARPE J G,SEIDEL E R.Polyamines are absorbed through a y+ amino acid carrier in rat intestinal epithelial cells[J].Amino Acids,2005,29(3):245-253.  

[18] BABBAR N,GERNER E W.Targeting polyamines and inflammation for cancer prevention[J].Recent Results in Cancer Research. Fortschritte der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer,2011,188:49-64.

[19] WOOD P L,KHAN M A,SMITH T,et al.Cellular diamine levels in cancer chemoprevention:modulation by ibuprofen and membrane plasmalogens[J].Lipids in Health and Disease,2011,10:214.

[20] PRAGER G W,POETTLER M,SCHMIDINGER M,et al.CD98hc (SLC3A2),a novel marker in renal cell cancer[J].European Journal of Clinical Investigation,2009,39(4):304-310.  

[21] UEMURA T,GERNER E W.Polyamine transport systems in mammalian cells and tissues[J].Methods in Molecula Biology,2011,720:339-348.

[22] XIE X,GILLIES R J,GERNER E W.Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates[J].The Journal of Biological Chemistry,1997,272(33):20484-20489.  

[23] UEMURA T,YERUSHALMI H F,TSAPRAILIS G,et al.Identification and characterization of a diamine exporter in colon epithelial cells[J].The Journal of Biological Chemistry,2008,283(39):26428-26435.  

[24] AOUIDA M,POULIN R,RAMOTAR D.The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5[J].The Journal of Biological Chemistry,2010,285(9):6275-6284.  

[25] FRIAUF E,RUST M B,SCHULENBORG T,et al.Chloride cotransporters,chloride homeostasis,and synaptic inhibition in the developing auditory system[J].Hearing Research,2011,279(1/2):96-110.

[26] CARRILLO C,CANEPA G E,ALGRANATI I D,et al.Molecular and functional characterization of a spermidine transporter (TcPAT12) from Trypanosoma cruzi[J].Biochemical and Biophysical Research Communications,2006,344(3):936-940.  

[27] KASHIWAGI K,MIYAMOTO S,NUKUI E,et al.Functions of potA and potD proteins in spermidine-preferential uptake system in Escherichia coli[J].The Journal of Biological Chemistry,1993,268(26):19358-19363.

[28] YAO X,LU C D.Functional characterization of the potRABCD operon for spermine and spermidine uptake and regulation in staphylococcus aureus[J].Current Microbiology,2014,69(1):75-78.  

[29] POULIN R,COWARD J K,LAKANEN J R,et al.Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress[J].The Journal of Biological Chemistry,1993,268(7):4690-4698.

[30] KHOMUTOV M A,WEISELL J,HYVONEN M,et al.Hydroxylamine derivatives for regulation of spermine and spermidine metabolism[J].Biochemistry,2013,78(13):1431-1446.

[31] HOSHINO K,MOMIYAMA E,YOSHIDA K,et al.Polyamine transport by mammalian cells and mitochondria:role of antizyme and glycosaminoglycans[J].The Journal of Biological Chemistry,2005,280(52):42801-42808.  

[32] ZHU C,LANG D W,COFFINO P.Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport[J].The Journal of Biological Chemistry,1999,274(37):26425-26430.  

[33] WANG J T H,KERR M C,KARUNARATNE S,et al.The SNX-PX-BAR family in macropinocytosis:the regulation of macropinosome formation by SNX-PX-BAR proteins[J].PLoS One,2010,5(10):e13763.

[34] WASSMER T,ATTAR N,HARTERINK M,et al.The retromer coat complex coordinates endosomal sorting and dynein-mediated transport,with carrier recognition by the trans-Golgi network[J].Developmental Cell,2009,17(1):110-122.  

[35] KAHANA C.Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor[J].Essays in Biochemistry,2009,46:47-62.

[36] LIAO C P,LASBURY M E,WANG S H,et al.Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages[J].The Journal of Biological Chemistry,2009,284(12):8174-8184.  

[37] ROY U K,RIAL N S,KACHEL K L,et al.Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis[J].Molecular Carcinogenesis,2008,47(7):538-553.  

[38] AZIZ S M,LIPKE D W,OLSON J W,et al.Role of ATP and sodium in polyamine transport in bovine pulmonary artery smooth cells[J].Biochemical Pharmacology,1994,48(8):1611-1618.  

[39] POULIN R,LESSARD M,ZHAO C Q.Inorganic cation dependence of putrescine and spermidine transport in human breast cancer cells[J].The Journal of Biological Chemistry,1995,270(4):1695-1704.  

[40] KAKINUMA Y,HOSHINO K,IGARASHI K.Characterization of the inducible polyamine transporter in bovine lymphocytes[J].European Journal of Biochemistry,1988,176(2):409-414.  

[41] DOT J,LLUCH M,BLANCO I,et al.Polyamine uptake in cultured astrocytes:characterization and modulation by protein kinases[J].Journal of Neurochemistry,2000,75(5):1917-1926.  

[42] MINCHIN R F,MARTIN R L.Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells[J].The International Journal of Biochemistry & Cell Biology,1997,29(3):447-454.  

[43] GROBLEWSKI G E,HARGITTAI P T,SEIDEL E R.Ca2+/calmodulin regulation of putrescine uptake in cultured gastrointestinal epithelial cells[J].The American Journal of Physiology,1992,262(6 Pt 1):C1356-C1363.

[44] BRACHET P,TOME D.Putrescine uptake by rabbit intestinal brush-border membrane vesicles[J].Biochemistry International,1992,27(3):465-475.

[45] BRACHET P,DEBBABI H,TOME D.Transport and steady-state accumulation of putrescine in brush-border membrane vesicles of rabbit small intestine[J].The American Journal of Physiology,1995,269(5):G754-G762.
文章导航

/