综述 Review

卵黄免疫球蛋白在畜禽生产中的研究与应用

展开
  • 扬州大学动物科学与技术学院, 扬州 225009
巨晓军(1989—),女,河北保定人,硕士研究生,从事家禽生产研究。E-mail:juxiaojun.2009@163.com

收稿日期: 2014-09-12

  网络出版日期: 2015-03-18

基金资助

江苏省自然科学基金项目(BK2012685);江苏农业三新工程项目(SXGC[2013]264);苏州市科技计划项目(SNG201214)

Research and Application of Egg Yolk Immunoglobulin in Animal Production

Expand
  • College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Received date: 2014-09-12

  Online published: 2015-03-18

摘要

卵黄免疫球蛋白又称卵黄抗体,是指蛋黄中存在的抗体,是母鸡血液中的免疫球蛋白传递至鸡蛋卵黄并在鸡胚孵育过程中及孵育后对雏鸡起保护作用的免疫球蛋白,对雏鸡早期生长发育作用突出。随着对卵黄免疫球蛋白研究的不断深入,卵黄免疫球蛋白在家禽、猪和反刍动物上都有了广泛的应用。目前,卵黄免疫球蛋白在畜禽生产及疾病预防治疗方面的作用越来越受到关注和重视。本文主要对卵黄免疫球蛋白的特性、作用机理及其在畜禽生产中的应用等方面作一综述。

本文引用格式

巨晓军, 杨海明, 王志跃, 马尹鹏, 谢艳娟, 蔡中梅 . 卵黄免疫球蛋白在畜禽生产中的研究与应用[J]. 动物营养学报, 2015 , 27(3) : 691 -697 . DOI: 10.3969/j.issn.1006-267x.2015.03.005

Abstract

The egg yolk immunoglobulin (IgY) is known as an egg yolk antibody. It origins from circulating immunoglobulin in hens, functions important roles during hatching and chick raising periods, especially in regulating early development. IgY has been widely used in poultry, pigs and ruminants. Now, more and more attentions have been paid to IgY in animal production and disease prevention. The objective of this paper was to review the characteristics and the action mechanism of yolk immunoglobulin and its application in animal production.

参考文献

[1] WILLIANMS J.Serum proteins and the livetins of hens egg yolk[J].Journal of Animal Science and Biotechnology,1962,83(l):346-348.

[2] SEHADE R,HLINAK A.Egg yolk antibodies,state of the art and future Prospeets[J].ALTEX,1996,13(Suppl.):5-9.

[3] ZHANG M J,YANG J,ZHU C Z,et al.Generation and application of anti-ouabain IgY antibodies[J].Molecular and Cellular Biochemistry,2011,358:241-247.

[4] ULMER-FRANCO A M,CHERIAN G,QUEZADA N,et al.Hatching egg and newly hatched chick yolk sac total IgY content at 3 broiler breeder flock ages[J].Poultry Science,2012,91(3):758-764.  

[5] SUN H C,CHEN S R,CAI X,et al.Correlation analysis of the total IgY level in hen serum,egg yolk and offspring serum[J].Journal of Animal Science and Biotechnology,2013,4:10.

[6] SCHADE R,BEHN I,ERHARD M,et al.Chicken egg yolk antibodies,production and application[J].Molecular Immunology,2001,38:619-625.

[7] TINI M,JEWELL U R,CAMENISH G,et al.Generation and application of chicken egg-yolk antibodies[J].Comparative Biochemistry and Physiology:Molecular & Integrative Physiology ,2002,03:569-574.

[8] 吴冠芸,潘华珍.分子化学与分子生物学实验常用数据手册[M].北京:科学出版社,2000.

[9] SHIMIZU M,NAGASHIMA H,SANO K,et al.Molecular stability of chicken and rabbit immunoglobulin G[J].Bioscience, Biotechnology,and Biochemistry,1992,56:270-274

[10] DAVALOS P L,ORTEGA-VINUESA J L,BASTOS-GONZÁLEZD D,et al.A comparative study between the absorption of IgY and IgG on latex particles[J].Journal of Biomaterials Science Polymer Edition,2000,11(6):657-673.  

[11] FU C Y,HUANG H,WANG X M,et al.Preparation and evaluation of anti-SARS coronavirus IgY from yolks of immunized SPF chickens[J].Journal of Virological Methods,2006,133(1):112- 115.  

[12] 刘端.抗咽喉炎链球菌鸡卵黄抗体的制备及检测[D].硕士学位论文.广州:广东工业大学,2011.

[13] 张伦.抗禽传染性法氏囊病毒卵黄抗体的研制及应用[D].硕士学位论文.保定:河北农业大学,2011.

[14] SUGITA K Y,SHIBATAK, YUN S S,et al.Immune functions in immunoglobulin Y isolated from egg yolk of hens immunized with various infectious bacteria[J].Bioscience,Biotechnology and Biochemistry,1996,60(5):886-888.  

[15] KOVACS-NOLAN J,MINE Y.Egg yolk antibodies for passive immunity[C]//DOYLE M P,KLAENHAMMER T R.Annual Review of Food Science and Technology.Canada:Department of Food Science,University of Guelph,2012:163-182.

[16] MIZUTANI N,SUGITA-KONISHI Y,OMOE K,et al.Advantages of immunoglobulin Y for the detection of staphylococcal enterotoxin A in a double-antibody sandwich enzyme-linked immunosorbent assay[J].International Journal of Food Scienceand Technology,2012,47:155-159.

[17] VEGA C G,BOK M,VLASOVA A N,et al.IgY antibodies protect against human rotavirus induced diarrhea in the neonatal gnotobiotic piglet disease model[J].PLoS One,2012,7(8):e42788.

[18] MOUSSA I M,HESSAN A M,ALEISA A M,et al.Protective efficacy of immunoglobulins Y prepared against cerastes cerastes snake venom in the Kingdom of Saudi Arabia[J].Saudi Medical Journal,2012,33(8):846-851.

[19] FERREIRA J A,SANTIAGO F M,SILVA M V,et al.Production,characterization and applications for Toxoplasma gondii-specific polyclonal chicken egg yolk immunoglobulins[J].PLoS One,2012,7(7):e40391.

[21] 程学慧,王劼,蒋思文,等.纯化ETEC K88菌毛特异性卵黄抗体的加工贮藏及体外抗黏附性研究[J].饲料研究,2005(4):3-5.

[22] YOKOYAMA H,PERALTA R C,DIAZ R,et al.Passive protective effect of chicken egg yolk immunoglobulins against experimenter enterimentel enterotoxigenic Escherichia coli[J].Infection and Immunity,1992,60:998-1007

[23] 王吉潭,李德发,龚利敏,等.抗猪大肠杆菌卵黄抗体变化规律及在体外对大肠杆菌生长的影响[J].饲料研究,2004(1):1-5.

[24] RAHIMI S,SHIRAZ Z M,SALEHI T Z,et al.Prevention of salmonella infection in poultry by specific egg-derived antibody[J].International Journal of Poultry Science,2007,6(4):230-235.  

[25] 王劼.猪源肠毒素大肠杆菌K88ac和F18ac菌毛蛋白基因的表达及其在卵黄抗体生产中的应用[D].博士学位论文.武汉:华中农业大学,2007.

[26] STADELMAN W J.The incredibly functional egg[J].Poultry Science,1999,78(6):807-811.  

[27] YOKOYAMA H,PERALTA R C,SENDO S,et al.Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and flurescent antibody testing[J].American Journal of Veterninary Research,1993,54:867-872.

[28] 杨海明,王志跃,江栋材,等.开食日粮中添加IgY对雏鸡生长性能及免疫器官、肠道生长发育的影响[J].中国饲料,2013,16:26-29.

[29] 陆健,张得才,韩娟,等.日粮中添加IgY对雏鸡生长性能、内脏器官生长和血清蛋白含量的影响[J].上海畜牧兽医通讯,2013(6):22-23,25.

[30] 朱锦兰,李焕友,冯定远,等.卵黄抗体添加剂与金霉素对肉鸭生长性能的影响比较研究[J].中国畜牧杂志,2005(6):36-37,50.

[31] 朱锦兰,李焕友,冯定远,等.卵黄抗体添加剂对肉鸭增重及有关代谢激素水平的影响[J].黑龙江畜牧兽医,2004,12:27-28.

[32] 朱锦兰,李焕友,冯定远,等.卵黄抗体和金霉素对肉鸭小肠绒毛高度的影响[J].中国家禽,2006,23:18-19.

[33] 朱锦兰,李焕友,冯定远,等.卵黄抗体添加剂对肉鸭生长性能及相关生理生化指标的影响[J].中国家禽,2004,24:13-15.

[34] CHALGHOUMI R,MARCQ C,THEWIS A,et al.Effects of feed supplementation with specific hen egg yolk antibody (immunoglobin Y) on Salmonella species cecal colonization and growth performances of challenged broiler chickens[J].Poultry Science,2009,88(10):2081-2092.  

[35] XU J J,REN C Z,WANG S S,et al.Protection efficacy of multivalent egg yolk immunoglobulin against eimeria tenella infection in chickens[J].Iranian Journal of Parasitology,2013,8(3):449-458.

[36] 武桂梅,王振辉,张桂荣,等.抗鸡白痢沙门杆菌病卵黄抗体粉饲料添加剂的研制[J].黑龙江畜牧兽医,2013(1):140-142.

[37] MAHDAVI A H,RAHMANI H R,NILI N,et al.Effects of dietary egg yolk antibody powder on growth performance,intestinal Escherichia coli colonization and immunocompetence of challenged broiler chicks[J].Poultry Science,2010,89(3):484-94.  

[38] XU Y P,LI X Y,JIN L J,et al.Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases:a review[J].Biotechnology Advances,2011,29:860-868.

[39] 张桂枝,靳双星.抗鸡新城疫和传染性法氏囊病二联卵黄抗体的研制及应用[J].中国畜牧兽医,2009(8):136-138.

[40] 张伦.抗禽传染性法氏囊病毒卵黄抗体的研制及应用[D].硕士学位论文.保定:河北农业大学,2011.

[41] FU C Y,HUANG H,WANG X M,et al.Preparation and evaluation of anti-SARS coronavirus IgY from yolks of immunized SPF chickens[J].Journal of Virological Methods,2006,133(1):112-115.  

[42] RAHIMI S,SALEHIFAR E.The effect of egg-derived antibody on prevention of avian influenza subtype H9N2 in layer chicken[J].International Journal of Poultry Science,2007,6(3):207-210.  

[43] 刘大鹏.鸭源抗鹅细小病毒卵黄抗体的制备[D].硕士学位论文.哈尔滨:东北农业大学,2011.

[44] 罗淡彬.鸡卵黄免疫球蛋白对早期断奶仔猪生长与免疫性能的影响[D].硕士学位论文.长沙:湖南农业大学,2006.

[45] 彭健,詹志春,程学慧,等.预防仔猪大肠杆菌性腹泻卵黄抗体研究进展[J].饲料工业,2005,6:47-50.

[46] 余冰,林晓钦,罗文丽,等.含胆囊收缩素抗体卵黄粉对断奶仔猪生产性能及养分消化率的影响[J].中国饲料,2009(1):19-21,25.

[47] 姜锦鹏.脂肪组织细胞膜蛋白卵黄抗体对猪脂肪沉积的调控和相关机理的研究[D].博士学位论文.南京:南京农业大学,2006.

[48] 索江华,吴玉臣,唐光武,等.猪圆环病毒2型高免卵黄抗体的研制与应用[J].中国畜牧兽医,2010,37(6):185-187.
文章导航

/