综述 Review

维生素D通过Wnt信号通路对肠道发育调控机制的研究进展

展开
  • 西南大学动物科技学院, 生物饲料与分子营养实验室, 重庆 400715
石宝石(1989—),男,福建厦门人,硕士研究生,从事分子营养学与生物饲料资源开发利用研究。E-mail:tto93@163.com

收稿日期: 2014-10-21

  网络出版日期: 2015-03-18

基金资助

国家973重点基础研究发展计划项目(2013CB127303);西南大学基本科研业务费(XDJK2011C030);重庆市自然科学基金(cstc2012jjA80001);西南大学博士基金(SWU111002)

Research Progress of Mechanism of Vitamin D Regulating Development of the Intestine through Wnt Signaling Pathway

Expand
  • Key Laboratory for Bio-Feed and Animal Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China

Received date: 2014-10-21

  Online published: 2015-03-18

摘要

Wnt信号通路广泛存在于脊椎和无脊椎动物体内,对动物机体各组织器官发育,如肝脏、肾脏、肠道等起着至关重要的作用。维生素D是一组脂溶性类固醇衍生物,维生素D不直接作用于靶器官,而是通过与维生素D受体(VDR)结合从而发挥其生物学效应。近年来研究表明,VDR可以通过影响Wnt信号通路的传导进而影响肠道发育,本文就VDR对Wnt信号通路的影响、Wnt信号通路对肠道发育的调控机制等方面作一综述,以期为Wnt信号通路在肠道发育调控研究提供参考。

本文引用格式

石宝石, 徐玲, 张小龙, 赖星, 刘亚娟, 唐志如 . 维生素D通过Wnt信号通路对肠道发育调控机制的研究进展[J]. 动物营养学报, 2015 , 27(3) : 698 -702 . DOI: 10.3969/j.issn.1006-267x.2015.03.006

Abstract

Wnt signaling pathway is widely present in both vertebrate and invertebrate animal's tissues and organs, it plays a very important role in many organs such as the liver, kidney and intestine. Vitamin D is a group of derivatives of fat-soluble steroid, it doesn't affect the target organ directly, and it works with the vitamin D receptor and exerts its biological effects. Many studies report that vitamin D receptor (VDR) can regulate the development of intestine through the Wnt signaling pathway. This paper reviewed the effect of VDR to Wnt signaling pathway and the Wnt signaling pathway regulating the development of intestine to make some reference for the study on regulating intestine development.

参考文献

[1] GAO C,CAO W P,BAO L,et al.Autophagy negatively regulates Wnt signalling by promoting dishevelled degradation[J].Nature Cell Biology,2010,12(8):781-790.  

[2] SUKHOTNIK I,GEYER T,POLLAK Y,et al.The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat[J].PLoS ONE,2014,9(11):e110675.

[3] SHI Y C,WORTON L,ESTEBAN L,et al.Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation[J].Bone,2007,41(1):87-96.  

[4] POLAKIS P.The many ways of Wnt in cancer[J].Current Opinion in Genetics & Development,2007,17(1):45-51.  

[5] NAKAMURA T,TSUCHIYA K,WATANABE M.Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision[J].Journal of Gastroenterology,2007,42(9):705-710.  

[6] GREGORIEFF A,CLEVERS H.Wnt signaling in the intestinal epithelium:from endoderm to cancer[J].Genes & Development,2005,19(8):877-890.  

[7] SETHI J K,VIDA-PUIG A.Wnt signalling and the control of cellular metabolism[J].Biochemical Journal,2010,427(1):1-17.  

[8] SHAO W J,WANG D Y,CHIANG Y T,et al.The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis[J].Diabetes,2013,62(3):789-800.  

[9] PINTO D,CLEVERS H.Wnt,stem cells and cancer in the intestine[J].Biology of the Cell,2005,97(3):185-196.  

[10] REYA T,CLEVERS H.Wnt signalling in stem cells and cancer[J].Nature,2005,434(7035):843-850.  

[11] BRYJA V,?AJÁNEK L,GRAHN A,et al.Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation[J].Acta Physiologica,2007,190(1):55-61.  

[12] KUHNERT F,DAVIS C R,WANG H T,et al.Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(1):266-271.  

[13] MANICASSAMY S,REIZIS B,RAVINDRAN R,et al.Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine[J].Science,2010,329(5993):849-853.  

[14] SANSOM O J,REED K R,HAYES A J,et al.Loss of Apc in vivo immediately perturbs Wnt signaling,differentiation,and migration[J].Genes & Development,2004,18(12):1385-1390.  

[15] KIPP A,BANNING A,VAN SCHOTHORST E M,et al.Four selenoproteins,protein biosynthesis,and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon[J].Molecular Nutrition & Food Research,2009,53(12):1561-1572.  

[16] KALER P,AUGENLICHT L,KLAMPFER L.Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells:a crosstalk interrupted by vitamin D3[J].Oncogene,2009,28(44):3892-3902.  

[17] BYERS S,SHAH S.Vitamin D and the regulation of Wnt/β-catenin signaling and innate immunity in colorectal cancer[J].Nutrition Reviews,2007,65(8 Pt 2):S118-S120.

[18] LARRIBA M J,ORDÓÑEZ-MORÁN P,CHICOTE I,at el.Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer[J].PLoS One,2011,6(8):e23524.

[19] PÁLMER H G,GONZÁLEZ-SANCHO JM,ESPADA J,et al.Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling[J].The Journal of Cell Biology,154(2):369-387.

[20] ORDÓÑEZ-MORÁN P,LARRIBA M J,PÁLMER H G,et al.RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression,phenotype,and Wnt pathway in colon cancer cells[J].The Journal of Cell Biology,2008,183(4):697-710.  

[21] LARRIBA M J,GONZÁLEZ-SANCHO J M,BARBÁCHANO A,et al.Vitamin D is a multilevel repressor of Wnt/β-catenin signaling in cancer cells[J].Cancers,2013,5(4):1242-1260.  

[22] GARCÍA-JIMÉNEZ C,GARCIA-MARTINEZ J M,CHOCARRO-CALVO A,et al.A new link between diabetes and cancer:enhanced WNT/beta-catenin signalling by high glucose[J].Journal of Molecular Endocrinology,2014,52(1):R51-R66.
文章导航

/