综述 Review

钙敏感受体介导的信号传导通路及生理功能

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  • 南京农业大学消化道微生物研究室, 南京 210095
赵秀英(1988—),女,河北保定人,硕士研究生,从事肠道微生态与动物健康研究。E-mail:2013105033@njau.edu.cn

收稿日期: 2014-10-09

  网络出版日期: 2015-03-18

基金资助

国家973项目(2013CB127301)

Calcium Sensing Receptor: Signaling Pathways and Physiological Functions

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  • Laboratory of Gastrointestinal Microbiology, Nanjing Agricultural University, Nanjing 210095, China

Received date: 2014-10-09

  Online published: 2015-03-18

摘要

钙敏感受体(CaSR)是G蛋白偶联受体(GPCRs)C家族的成员,其在神经系统、心血管系统、胃肠道、肾脏及骨组织中有广泛的分布,当与激动剂及变构调节剂结合后,激活下游相关信号通路,对于机体钙稳态的维持、细胞的增殖分化、免疫及多种内分泌激素的释放具有重要调节作用。目前的研究报告主要来自于牛、人、鼠等,对家畜和其他动物的研究还较少,对机体各项生命活动的调控作用也不明确。为此,本文从CaSR的发现、结构、介导的信号活动及生理作用等方面作一综述,以期为研究CaSR调节动物生理活动的机制及发挥的生理功能奠定理论基础。

本文引用格式

赵秀英, 杭苏琴, 朱伟云 . 钙敏感受体介导的信号传导通路及生理功能[J]. 动物营养学报, 2015 , 27(3) : 703 -714 . DOI: 10.3969/j.issn.1006-267x.2015.03.007

Abstract

Calcium-sensing receptor (CaSR) is a member of the G protein-coupled receptors (GPCRs) C family, and wildly expressed in nervous system, cardiovascular system, gastrointestinal tract, kidney and bone tissue. After combined with its agonists and allosteric modulators, the downstream signaling pathways are activated, which play very important roles in the regulation of calcium homeostasis, cell proliferation and differentiation, immune function and endocrine hormone releasing. However, recent researches mostly focus on cattle, human and mice. The studies on livestock and other animals are limited, and undergoing mechanisms of physiological functions of CaSR mediation are not clear enough. Therefore, this paper summarized the discovery, the structure, mediated signaling events and physiological effects of the CaSR, in order to lay a theoretical foundation for further study on livestock and other animals.

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