综述 Review

中链脂肪酸在新生仔猪上的研究与应用

  • 王钰飞 ,
  • 齐岩 ,
  • 铃田靖幸 ,
  • 陈燕军 ,
  • 优克刚 ,
  • 安福生 ,
  • 薛廷伍
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  • 1. 中国牧工商(集团)总公司, 北京 100070;
    2. 日本全药工业珠式会社亚洲事务部, 北京 100027;
    3. 中国农业科学院上海兽医研究所, 上海 200241

收稿日期: 2014-12-26

  网络出版日期: 2015-07-07

Research and Application of Medium-Chain Fatty Acids in Neonatal Piglets

  • WANG Yufei ,
  • QI Yan ,
  • Yasuyuki Suzuta ,
  • CHEN Yanjun ,
  • Katsugo Yu ,
  • AN Fusheng ,
  • XUE Tingwu
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  • 1. China Animal Husbandry Group (CAHG), Beijing 100070, China;
    2. Asian Business Unit, Nippon Zenyaku Kogyo Co., Ltd (ZENOAQ), Beijing 100027, China;
    3. Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences, Shanghai 200241, China

Received date: 2014-12-26

  Online published: 2015-07-07

摘要

中链脂肪酸(medium chain fatty acids,MCFAs)是含有6~12个碳原子的饱和脂肪酸,常温下呈液态。因其独特的结构和代谢途径使其能够被新生仔猪快速有效地消化、吸收和利用,快速补充能量,同时还具有抑菌、调节肠道微生物菌群和促生长的作用。新生仔猪补充饲喂MCFAs可以显著提高新生仔猪的断奶成活率和日增重,改善肠道微生物菌群,提高新生仔猪免疫功能。但MCFAs使用不当时也可能会引起动物体内酮体含量过高、影响仔猪摄乳量等问题。本文综述了MCFAs在新生仔猪上的研究与应用以及存在的问题和解决措施。

本文引用格式

王钰飞 , 齐岩 , 铃田靖幸 , 陈燕军 , 优克刚 , 安福生 , 薛廷伍 . 中链脂肪酸在新生仔猪上的研究与应用[J]. 动物营养学报, 2015 , 27(7) : 1997 -2004 . DOI: 10.3969/j.issn.1006-267x.2015.07.003

Abstract

The length of medium chain fatty acids (MCFAs) ranges from 6 to 12 carbons atoms and it is liquid at room temperature. MCFAs possess many unique nutritional and metabolic characteristics and can be easily digested, absorbed and utilized effectively and quickly oxidized to supply energy for neonatal piglets. Besides MCFAs also have positive effects on antivirus, regulating macrobiotic flora and promoting growth. Supplementing the diet with MCFAs can help to improve the performance and survival rate of neonatal piglets and has an impact on the regulation of immune function. However, MCFAs may be to increase the level of ketone bodies content and decrease milk intake of neonatal piglets when misuse it. This paper mainly focused on the research and application of MCFAs in neonatal piglets and made a summary of the existing problems and the solving measures.

参考文献

[1] BENEVENGA N J,STEINMAN-GOLDSWORTHY J K,CRENSHAW T D,et al.Utilization of medium-chain triglycerides by neonatal piglets:Ⅰ.Effects on milk consumption and body fuel utilization[J].Journal of Animal Science,1989,67(12):3331-3339.

[2] SPICER E M,DRIESEN S J,FAHY V A,et al.Causes of preweaning mortality on a large intensive piggery[J].Australian Veterinary Journal,1986,63(3):71-75.  

[3] DE VOS M,CHE L,HUYGELEN V,et al.Nutritional interventions to prevent and rear low-birthweight piglets[J].Journal of Animal Physiology and Animal Nutrition,2013,98(4):1-11.

[4] BAXTER E M,JARVIS S,D'EATH R B,et al.Investigating the behavioural and physiological indicators of neonatal survival in pigs[J].Theriogenology,2008,69(6):773-783.  

[5] DEVILLERS N,FARMER C,LE DIVIDICH J,et al.Variability of colostrum yield and colostrum intake in pigs[J].Animal,2007,1(7):1033-1041.  

[6] MARTEN B,PFEUFFER M,SCHREZENMEIR J.Medium-chain triglycerides[J].International Dairy Journal,2006,16(11):1374-1382.  

[7] 杨金堂,黄克和,王建林,等.中链脂肪酸在畜牧业上应用的研究进展[J].畜牧与兽医,2009,41(5):100-105.

[8] GU X,LI D.Fat nutrition and metabolism in piglets:a review[J].Animal Feed Science and Technology,2003,109(1/2/3/4):151-170.

[9] ZENTEK J,BUCHHEIT-RENKO S,FERRARA F,et al.Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets[J].Animal Health Research Reviews,2011,12(1):83-93.  

[10] CHIANG S H,PETTIGREW J E,CLARKE S D,et al.Limits of medium-chain and long-chain triacylglycerol utilization by neonatal piglets[J].Journal of Animal Science,1990,68(6):1632-1638.

[11] HEO K N,LIN X,HAN I K,et al.Medium-chain fatty acids but not L-carnitine accelerate the kinetics of [14C] triacylglycerol utilization by colostrum-deprived newborn pigs[J].The Journal of Nutrition,2002,132(7):1989-1994.

[12] MEKBUNGWAN A,YAMAUCHI K.Growth performance and histological intestinal alterations in piglets fed dietary raw and heated pigeon pea seed meal[J].Histology and Histopathology,2004,19(2):381-389.

[13] ODLE J,LIN X I,WIELAND T M,et al.Emulsification and fatty acid chain length affect the kinetics of [14 C]-medium-chain triacylglycerol utilization by neonatal piglets[J].The Journal of Nutrition,1994,124(1):84-93.

[14] CARVAJAL O,NAKAYAMA M,KISHI T,et al.Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats[J].Lipids,2000,35(12):1345-1352.  

[15] TURNER N,HARIHARAN K,TIDANG J,et al.Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent potent tissue-specific effects of medium-chain fatty acids[J].Diabetes,2009,58(11):2547-2554.  

[16] ST-ONGE M P,BOURQUE C,JONES P J H,et al.Medium-versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women[J].International Journal of Obesity,2003,27(1):95-102.  

[17] RASMUSSEN B B,HOLMBÄCK U C,VOLPI E,et al.Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle[J].Journal of Clinical Investigation,2002,110(11):1687-1693.  

[18] ODLE J,BENEVENGA N J,CRENSHAW T D.Utilization of medium-chain triglycerides by neonatal piglets:Ⅱ.Effects of even-and odd-chain triglyceride consumption over the first 2 days of life on blood metabolites and urinary nitrogen excretion[J].Journal of Animal Science,1989,67(12):3340-3351.

[19] LEE H F,CHIANG S H.Energy value of medium-chain triglycerides and their efficacy in improving survival of neonatal pigs[J].Journal of Animal Science,1994,72(1):133-138.

[20] 朱成林,孙家鹏.中链脂肪酸对新生仔猪成活率和增重的作用[J].新疆畜牧业,2000(增刊):11-14.

[21] 陈赞谋.添加中链脂肪酸制剂对哺乳仔猪饲养效果的研究[J].家畜生态,1999,20(1)4-6.

[22] HONG S M,HWANG J H,KIM I H.Effect of medium-chain triglyceride (MCT) on growth performance,nutrient digestibility,blood characteristics in weanling pigs[J].Asian-Australasian Journal of Animal Sciences,2012,25(7):1003-1008.  

[23] HANCZAKOWSKA E,ŠWIATKIEWICZ M,HANCZAKOWSKI P,et al.Medium-chain fatty acids as feed supplements for weaned piglets[J].Medycyna Weterynaryjna,2010,66(5):331-334.

[24] CERA K R,MAHAN D C,REINHART G A.Evaluation of various extracted vegetable oils,roasted soybeans,medium-chain triglyceride and an animal-vegetable fat blend for postweaning swine[J].Journal of Animal Science,1990,68(9):2756-2765.

[25] HAN Y K,HWANG I L H,THACKER P A.Use of a micro-encapsulated eucalyptus-medium chain fatty acid product as an alternative to zinc oxide and antibiotics for weaned pigs[J].Journal of Swine Health and Production,2011,19(1):34-43.

[26] LAY D C Jr,MATTERI J A,CARROLL T J,et al.Preweaning survival in swine[J].Journal of Animal Science,2002,80(Suppl.1):E74-E86.

[27] CASELLAS J,CASAS X,PIEDRAFITA J,et al.Effect of medium- and long-chain triglyceride supplementation on small newborn-pig survival[J].Preventive Veterinary Medicine,2005,67(2/3):213-221.

[28] LIN C L,CHIANG S H,LEE H F.Causes of reduced survival of neonatal pigs by medium-chain triglycerides:blood metabolite and behavioral activity approaches[J].Journal of Animal Science,1995,73(7):2019-2025.

[29] LEPINE A J,BOYD R D,WELCH J.Effect of colostrum intake on plasma glucose,non-esterified fatty acid and glucoregulatory hormone patterns in the neonatal pig[J].Domestic Animal Endocrinology,1989,6(3):231-241.  

[30] SPRONG R C,HULSTEIN M F E,VAN DER MEER R.Bovine milk fat components inhibit food-borne pathogens[J].International Dairy Journal,2002,12(2/3):209-215.

[31] LALLÈS J P,BOSI P,SMIDT H,et al.Nutritional management of gut health in pigs around weaning[J].Proceedings of the Nutrition Society,2007,66(2):260-268.  

[32] DIERICK N A,DECUYPERE J A,DEGEYTER I.The combined use of whole Cuphea seeds containing medium chain fatty acids and an exogenous lipase in piglet nutrition[J].Archives of Animal Nutrition,2003,57(1):49-63.  

[33] CHWEN L T,FOO H L,THANH N T,et al.Growth performance,plasma fatty acids,villous height and crypt depth of preweaning piglets fed with medium chain triacylglycerol[J].Asian Australasian Journal of Animal Sciences,2013,26(5):700-704.  

[34] WOOLFORD M K.Microbiological screening of the straight chain fatty acids (C1-C12) as potential silage additives[J].Journal of the Science of Food and Agriculture,1975,26(2):219-228.  

[35] MROZ Z,KOOPMANS S J,BANNINK A,et al.Chapter 4 carboxylic acids as bioregulators and gut growth promoters in nonruminants[J].Biology of Growing Animals,2006,4:81-133.

[36] DECUYPERE J A,DIERICK N A.The combined use of triacylglycerols containing medium-chain fatty acids and exogenous lipolytic enzymes as an alternative to in-feed antibiotics in piglets:concept,possibilities and limitations.An overview[J].Nutrition Research Reviews,2003,16(2):193-210.  

[37] TSUCHIDO T,HIRAOKA T,TAKANO M,et al.Involvement of autolysin in cellular lysis of Bacillus subtilis induced by short- and medium-chain fatty acids[J].Journal of Bacteriology,1985,162(1):42-46.

[38] BERGSSON G,STEINGRIÍMSSON Ó,THORMAR H.Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori[J].International Journal of Antimicrobial Agents,2002,20(4):258-262.  

[39] ZENTEK J,FERRARA F,PIEPER R,et al.Effects of dietary combinations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets[J].Journal of Animal Science,2013,91(7):3200-3210.  

[40] RICKE S C.Perspectives on the use of organic acids and short chain fatty acids as antimicrobials[J].Poultry Science,2003,82(4):632-639.  

[41] 何健.中链甘油三酯在动物体内的代谢及应用研究[J].中国油脂,2004,29(1):14-18.

[42] PRICE K L,LIN X,VAN HEUGTEN E,et al.Diet physical form,fatty acid chain length,and emulsification alter fat utilization and growth of newly weaned pigs[J].Journal of Animal Science,2013,91(2):783-792.  

[43] WIELAND T M,LIN X,ODLE J.Emulsification and fatty acid chain length affect the utilization of medium-chain triglycerides by neonatal pigs[J].Journal of Animal Science,1993,71(6):1869-1874.

[44] CHI F,LEPINE A J.Effect of dietary lipid on growth performance and fatty acid binding protein activity in the liver and small intestine of the weanling pig[J].Journal of Animal Science,1993,71:178.

[45] 张鹤亮,呙于明.断奶仔猪脂肪营养研究进展[J].中国饲料,1998(19):15-17.

[46] LEPINE A J,GARLEB K A,REINHART G A,et al.Dietary nitrogen and lipid utilization by growing pigs fed structured triacylglycerides synthesized from medium-chain triacylglycerides and menhaden oil[J].Journal of Animal Science,1994,72(4):938-945.
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