综述 Review

腺苷酸活化蛋白激酶/哺乳动物雷帕霉素靶蛋白信号通路介导能量和必需氨基酸调控乳蛋白合成

  • 王珊珊 ,
  • 王加启 ,
  • 高海娜 ,
  • 闫素梅 ,
  • 郑楠
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  • 1. 中国农业科学院北京畜牧兽医研究所, 农业部奶产品质量安全风险评估实验室(北京), 北京 100193;
    2. 内蒙古农业大学动物科学学院, 呼和浩特 010018;
    3. 农业部奶及奶制品质量监督检验测试中心(北京), 北京 100193;
    4. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    5. 甘肃农业大学动物科学技术学院, 兰州 730070

收稿日期: 2015-03-17

  网络出版日期: 2015-08-13

基金资助

国家重点基础研究发展计划(2011CB100805);现代农业产业技术体系专项资金(nycytx-04-01);中国农业科学院科技创新工程(ASTIP-IAS12)

Regulation of Milk Protein Synthesis by Energy and Essential Amino Acids through Adenosine 5'-Monophosphate-Activated Protein Kinase/Mammalian Target Rapamycin Signaling Pathway

  • WANG Shanshan ,
  • WANG Jiaqi ,
  • GAO Haina ,
  • YAN Sumei ,
  • ZHENG Nan
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  • 1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
    3. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
    4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    5. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China

Received date: 2015-03-17

  Online published: 2015-08-13

摘要

乳蛋白合成是以必需氨基酸为底物的耗能过程。腺苷酸活化蛋白激酶(AMPK)是AMPK信号通路的重要分子;可通过感受细胞能量状态的方式来维持能量平衡,从而为乳蛋白合成提供充足的能量。哺乳动物雷帕霉素靶蛋白(mTOR)是AMPK信号通路重要的下游靶点;必需氨基酸主要以mTOR介导的信号通路调控乳蛋白合成。本文主要综述了能量和必需氨基酸通过AMPK/mTOR信号通路对乳蛋白合成调控的研究进展,旨在进一步阐明能量和必需氨基酸对乳蛋白合成调控的作用机理。

本文引用格式

王珊珊 , 王加启 , 高海娜 , 闫素梅 , 郑楠 . 腺苷酸活化蛋白激酶/哺乳动物雷帕霉素靶蛋白信号通路介导能量和必需氨基酸调控乳蛋白合成[J]. 动物营养学报, 2015 , 27(8) : 2342 -2348 . DOI: 10.3969/j.issn.1006-267x.2015.08.005

Abstract

Milk protein synthesis is a process that consumes essential amino acids (EAA) and energy. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important molecule in AMPK signaling pathway, which can maintain its energy balance through the way of feeling cellular energy state with the aim of providing sufficient energy for milk protein synthesis. Mammalian target rapamycin (mTOR) is an important downstream target in AMPK signaling pathway by that EAA mainly mediated milk protein synthesis. This review summarized regulatory roles of energy and EAA through AMPK/mTOR signaling pathway in process of milk protein synthesis.

Key words: AMPK; mTOR; EAA; energy; milk protein

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