综述 Review

饥饿激素与能量代谢

  • 张娜 ,
  • 丁艳平 ,
  • 王建林 ,
  • 邵宝平
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  • 1. 兰州大学生命科学学院动物学与发育生物学研究所, 兰州 730000;
    2. 西北师范大学生命科学学院, 兰州 730070

收稿日期: 2015-02-06

  网络出版日期: 2015-08-13

基金资助

国家自然科学基金项目(青年基金31000190,地区基金31060141);兰州大学中央高校基本科研业务费专项资金

Ghrelin and Energy Metabolism

  • ZHANG Na ,
  • DING Yanping ,
  • WANG Jianlin ,
  • SHAO Baoping
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  • 1. Institute of Zoology and Developmental Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China;
    2. College of Life Sciences, Northwest Normal University, Lanzhou 730070, China

Received date: 2015-02-06

  Online published: 2015-08-13

摘要

饥饿激素(ghrelin)是生长激素促分泌素受体的唯一内源性配体,也是唯一可以在外周刺激食欲的激素。ghrelin在机体食欲、体重、胃肠功能、脂肪代谢、葡萄糖代谢及脂类代谢等生理活动的调节中发挥着重要作用。ghrelin的酰基化是与其受体结合产生相应生物学效应的前提。本文系统综述了ghrelin在能量代谢中的作用模式与分子机制。

本文引用格式

张娜 , 丁艳平 , 王建林 , 邵宝平 . 饥饿激素与能量代谢[J]. 动物营养学报, 2015 , 27(8) : 2349 -2360 . DOI: 10.3969/j.issn.1006-267x.2015.08.006

Abstract

Ghrelin is the only endogenous ligand of growth hormone secretagogue receptor (GHSR), and is also the only appetite-stimulating hormone in the periphery. Ghrelin plays an important role in the regulation of the appetite, weight, gastrointestinal function, fat metabolism, glucose metabolism, and lipid metabolism, ect. The acidylation of ghrelin plays an essential role in producing the biological effects combining with its receptor. The article summarized that the function patterns and molecular mechanisms of ghrelin in energy metabolism.

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