综述 Review

钠离子依赖性中性氨基酸转运载体2特性、表达调控及功能

  • 李光燃 ,
  • 谭碧娥 ,
  • 管桂萍 ,
  • 印遇龙
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  • 1. 中国科学院亚热带农业生态研究所, 中国科学院亚热带农业生态过程重点实验室, 湖南省畜禽健康养殖工程技术中心, 农业部中南动物营养与饲料科学观测实验站, 长沙 410125;
    2. 中国科学院大学, 北京 100049;
    3. 湖南农业大学生物科学技术学院, 长沙 410128

收稿日期: 2015-05-14

  网络出版日期: 2015-11-21

基金资助

国家自然科学基金(31372326,31330075,31301989);国家重点基础研究发展计划(2013CB127302)

Sodium Dependent Neutral Amino Acid Transporter 2: Characteristics, Expression Regulation and Function

  • LI Guangran ,
  • TAN Bi ,
  • GUAN Guiping ,
  • YIN Yulong
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  • 1. Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    2. University of Chinese Academy of Sciences, Beijing 100049, China;
    3. College of Biology and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2015-05-14

  Online published: 2015-11-21

摘要

转运系统A载体——钠离子依赖性的中性氨基酸转运载体2(SNAT2)是近年发现的氨基酸转运感受体的典型代表,是体内主要的氮转运载体。SNAT2通过转运过程调节细胞内氨基酸浓度,进而调控细胞内氨基酸感受体的下游信号,发挥氨基酸转运载体和信号受体的双重功能,而成为近年氨基酸营养感应的研究热点。本文围绕SNAT2的分子特性、生物学特性、表达调控及其介导的氨基酸感应信号的研究进展进行综述。

本文引用格式

李光燃 , 谭碧娥 , 管桂萍 , 印遇龙 . 钠离子依赖性中性氨基酸转运载体2特性、表达调控及功能[J]. 动物营养学报, 2015 , 27(11) : 3338 -3344 . DOI: 10.3969/j.issn.1006-267x.2015.11.004

Abstract

Sodium-dependent neutral amino acid transporter 2 (SNAT2), which belongs to transport system A,is the main transporter of nitrogen in vivo. SNAT2 is well known as typical amino acid transceptor founded in recent years, which plays a dual role of amino acid transporter and receptor through regulating the concentration of intracellular amino acids, thereby regulating the downstream signal of intracellular amino acid receptors. Because of its unique features, SNAT2 has become an attractive topic in nutritional induction of amino acids in recent years. In the present review, the new research progresses on the molecular characteristics, biological properties, expression regulation and amino acids sensing signaling of SNAT2 were summarized.

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