综述 Review

牛磺酸消炎抗氧化机理及其在幼龄动物中的应用

  • 徐玲 ,
  • 王庆争 ,
  • 杜孝贵 ,
  • 曹伟平 ,
  • 唐志如 ,
  • 张小龙
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  • 1. 西南大学动物科技学院, 生物饲料与分子营养实验室, 重庆 400715;
    2. 湖南省永兴县樟树中学, 郴州 423311

收稿日期: 2015-06-08

  网络出版日期: 2015-12-14

基金资助

雅琪创新基金项目(YQ201401);国家973重点基础研究发展计划项目(2013CB127303);农业部948项目(2015Z74);中央高校基本业务费专项资金(XDJK2014B028,XDJK2015D005)

Anti-Inflammatory and Antioxidant Mechanism of Taurine and Its Application in Young Animals

  • XU Ling ,
  • WANG Qingzheng ,
  • DU Xiaogui ,
  • CAO Weiping ,
  • TANG Zhiru ,
  • ZHANG Xiaolong
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  • 1. Key Laboratory for Bio-Feed and Animal Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China;
    2. Yongxing County Zhangxu Middle School, Chenzhou 423311, China

Received date: 2015-06-08

  Online published: 2015-12-14

摘要

牛磺酸广泛存在于动物组织细胞内,具有消炎抗氧化生物学功能。目前研究发现牛磺酸消炎抗氧化机理包括:通过雷帕霉素靶蛋白(mTOR)信号通路促进肠黏膜修复,通过抑制Toll样受体4(TLR4)信号通路缓解肠黏膜炎症反应,通过瞬时受体电位通道M2(TRPM2)离子通道改善细胞线粒体生理功能。本文就牛磺酸消炎抗氧化机理以及在幼龄动物中的应用进行综述,以期为牛磺酸在消炎抗氧化方面研究提供参考意义。

本文引用格式

徐玲 , 王庆争 , 杜孝贵 , 曹伟平 , 唐志如 , 张小龙 . 牛磺酸消炎抗氧化机理及其在幼龄动物中的应用[J]. 动物营养学报, 2015 , 27(12) : 3683 -3688 . DOI: 10.3969/j.issn.1006-267x.2015.12.006

Abstract

Taurine is widely found in the cells of animal tissues and has anti-inflammatory and antioxidant biological function. Recent studies have found that anti-inflammatory and anti- oxidative mechanism of taurine is as follows:taurine promotes the repair of intestinal mucosa through mammalian target of rapamyein(mTOR) signaling pathway; taurine alleviates the inflammatory reaction of intestinal mucosa by inhibiting Toll-like-receptors(TLR4) signaling pathway; taurine improves mitochondrial function in cell physiology through the transient receptor potential melastatin type 2(TRPM2) ion channels. In order to provide reference significance for taurine in anti-inflammatory and anti-oxidative research, the anti-inflammatory and anti-oxidative mechanism of taurine and the application of taurine in the young animals were reviewed in this paper.

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