综述 Review

胃饥饿素:生物学特征及对动物采食量的调控

  • 李振远 ,
  • 李方方 ,
  • 张勇 ,
  • 朱宇旌
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  • 沈阳农业大学畜牧兽医学院, 沈阳 110866

收稿日期: 2015-07-17

  网络出版日期: 2016-01-22

基金资助

国家自然科学基金(31440082,31101253)

Ghrelin: Biological Characteristics and Modulation of Feed Intake

  • LI Zhenyuan ,
  • LI Fangfang ,
  • ZHANG Yong ,
  • ZHU Yujing
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  • College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2015-07-17

  Online published: 2016-01-22

摘要

胃饥饿素又称作生长激素释放肽,最初是在大鼠的胃内被发现的,它是生长激素促分泌素受体1A(GHSR-1A)的一种内源性配体。在下丘脑弓形核(ARC)及室旁核(PVN)高度表达GHSR-1A的区域,胃饥饿素结合GHSR-1A后,产生一系列生物学效应。本文综述了胃饥饿素的生物学特征及功能、对动物采食量调控的机制、影响胃饥饿素基因表达调控的因素和反馈抑制以及前景展望。

本文引用格式

李振远 , 李方方 , 张勇 , 朱宇旌 . 胃饥饿素:生物学特征及对动物采食量的调控[J]. 动物营养学报, 2016 , 28(1) : 35 -42 . DOI: 10.3969/j.issn.1006-267x.2016.01.006

Abstract

Ghrelin, also known as growth hormone releasing peptide, is originally discovered in the stomach of rats, and it is an endogenous ligand of growth hormone secretagogue receptor-1A (GHSR-1A). In the hypothalamic arcuate nucleus (ARC) and paraventricular nucleus(PVN), GHSR-1A is highly expressed. In these areas, ghrelin has a series of biological effects after combining GHSR-1A. This paper reviewed biological characteristics and functions, the regulation mechanism on animal feed intake, factors influencing gene expression and modulation, feedback inhibition of ghrelin, and gave outlooks for researches into ghrelin in the future.

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