全佳慧 , 姜宁 , 张爱忠 , 黄福佳 , 姜殿慧 , 宋磊 , 张伟庆 . Toll样受体及其对肠黏膜免疫的调节作用[J]. 动物营养学报, 2016 , 28(1) : 43 -49 . DOI: 10.3969/j.issn.1006-267x.2016.01.007

[1] AKIRA S,TAKEDA K.Toll-like receptor signalling [J].Nature Review Immunology,2004,4(7):499-511.

[2] AKIRA S,TAKEDA K,KAISHO T.Toll-like receptors:critical proteins linking innate and acquired immunity[J].Nature Immunology,2001,2(8):675-680.

[3] THOMPSON A J V,LOCARNINI S A.Toll-like receptors,RIG-I-like RNA helicases and the antiviral innate immune response[J].Immunol Cell Biology,2007,85(6):435-445.

[4] LUO J,LI W,DUAN Y F,et al.Host discriminates between probiotics and pathogens:impact of toll like receptor 5-flagellin interaction and evolution[J].Microbiology China,2014,41(7):1368-1375.

[5] KAWAI T,AKIRA S.The roles of TLRs,RLRs and NLRs in pathogen recognition[J].International Immunology,2009,21(4):317-337.

[6] BEUTLER B A.TLRs and innate immunity[J].Blood,2009,113(7):1399-1407.

[7] AKIRA S,UEMATSU S,TAKEUCHI O.Pathogen recognition and innate immunity[J].Cell 2006,124(4):783-801.

[8] GEORGEL P,JIANG Z F,KUNZ S,et al.Vesicular stomatitis virus glycoprotein G activates a specific antiviral toll-like receptor 4-dependent pathway[J].Virology,2007,362(2):304-313.

[9] JUDE B A,POBEZINSKAYA Y,BISHOP J,et al.Subversion of the innate immune system by a retrovirus[J].Nature Immunology,2003,4(6):573-578.

[10] KURT-JONES E A,POPOVA L,KWINN L,et al.Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus[J].Nature Immunology,2000,1(5):398-401.

[11] TSAN M F,GAO B.Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors[J].Journal of Endotoxin Research,2007,13(1):6-14.

[12] KAGAN J C,SU T,HORNG T,et al.TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β[J].Nature Immunology,2008,9(4):361-368.

[13] MENCIN A,KLUWE J,SCHWABE R F.Toll-like receptors as targets in chronic liver diseases[J].Gut,2009,58(5):704-720.

[14] CHENG Y X,QI X Y,HUANG J L,et al.Toll-like receptor 4 signaling promotes the immunosuppressive cytokine production of human cervical cancer[J].European Journal of Gynaecological Oncology,2012,33(3):291-294.

[15] LIEW F Y,XU D,BRINT E K,et al.Negative regulation of Toll-like receptor-mediated immune responses[J]. Nature Reviews Immunology,2005,5(6):446-458.

[16] WELLS J M,LOONEN L M P,KARCZEWSKI J M.The role of innate signaling in the homeostasis of tolerance and immunity in the intestine[J].Int J Med Microbiol,2010,300(1):41-48.

[17] WELLS J M,ROSSI O,MEIJERINK M,et al.Epithelial crosstalk at the microbiota-mucosal interface[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(Suppl.1):4607-4614.

[18] CARIO E,ROSENBERG I M,BRANDWEIN S L,et al.Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors[J].Journal of Immunology,2000,164(2):966-972.

[19] ELIA P P,TOLENTINO Y E,BERNARDAZZI C,et al.The role of innate immunity receptors in the pathogenesis of inflammatory bowel disease[J].Mediators of Inflammation,2015,2015:936193.

[20] TEIXEIRA L D,SILVA O N,MIGLIOLO L,et al.In vivo antimicrobial evaluation of an alanine-rich peptide derived from Pleuronectes americanus[J].Peptides,2013,42:144-148.

[21] 曾炯,黄兴国,邬理洋.微生态制剂与肠黏膜免疫关系的研究进展[J].饲料工业,2010,31(4): 58-60.

[22] 薛现凤.猪β-防御素抗菌、抗氧化功能及其对肠上皮细胞黏膜屏障功能的影响[D].硕士学位论文,杭州:浙江大学,2012.

[23] RUMIO C,BESUSSO D,PALAZZO M,et al.Degranulation of paneth cells via Toll-like receptor 9 [J].The American Journal of Pathology,2004,165(2):373-381.

[24] HOOPER L V,STAPPENBECK T S,HONG C,et al.Angiogenins:a new class of microbicidal proteins involved in innate immunity[J].Nature Immunology,2003,4:269-273.

[25] FAHLGREN A,HAMMARSTRÖM S,DANIELSSON Å,et al.Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis[J].Clinical & Experimental Immunology,2003,131(1):90-101.

[26] OGUSHI,WADA A,NIIDOME T,et al.Salmonella enteritidis FliC (flagella filament protein) induces human β-defensin-2 mRNA production by Caco-2 cells[J].Journal of Biological Chemistry,2001,276(32):30521-30526.

[27] OGUSHI K,WADA A,NIIDOME T,et al.Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells[J].Journal of Biological Chemistry,2004,279(13):12213-12219.

[28] VORA P,YOUDIM A,THOMAS L S,et al. β-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells[J].Journal of Immunology,2004,173(9):5398-5405.

[29] 左增妍,张彩.肠道黏膜免疫耐受机制研究进展[J].现代免疫学,2015,35(1):68-71.

[30] RAKOFF-NAHOUM S,PAGLINO J,ESLAMI-VARZANEH F,et al.Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis [J].Cell,2004,118(2):229-241.

[31] 蔡杰,唐志如,邓欢,等.动物肠道黏膜抗菌肽维持微生物区系平衡机制研究进展[J].动物营养学报,2014,26(8):2071-2076.

[32] CHEEMA U B,YOUNAS M,SULTAN J I,et al.Antimicrobial peptides:an alternative of antibiotics in ruminants[J].Advances in Agricultural Biotechnology,2011(2):15-21.

[33] WU S D,ZHANG F R,HUANG Z M,et al.Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli[J].Peptides,2012,35(2):225-230.

[34] SCHOSTER A,KOKOTOVIC B,PERMIN A,et al.In vitro inhibition of Clostridium difficile and CloStridium perfringens by commercial probiotic strains[J].Anaerobe,2013,20:36-41.

[35] 唐志刚,温超,王恬,等.益生菌与家禽肠道免疫调控的构效关系[J].畜牧与兽医,2012,44(8):86-89.

[36] BUFFIE C G,PAMER E G.Microbiota-mediated colonization resistance against intestinal pathogens[J].Nature Reviews Immunology,2013,13(11):790-801.